Crebinostat

Xi'an Faithful BioTech Co., Ltd: Your Trusted Crebinostat Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd provides high-quality Crebinostat, we are a rapidly growing professional supplier of pharmaceutical raw materials. Our natural products, inhibitors, pharmaceutical intermediates, and research tools are widely used in drug research and development, molecular biology, drug analysis, pharmacology, drug metabolism, pharmacy, and other scientific research fields.

Crebinostat Introduction

Crebinostat is an effective histone deacetylase (HDAC) inhibitor, with IC50 values of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM for HDAC1, HDAC2, HDAC3, and HDAC6, respectively. Crebinostat can induce acetylation of histone H3 and histone H4, and enhance the expression of the target gene Egr1 for cAMP chemobook response element binding protein (CREB). Crebinostat can increase the density of synaptic protein 1 spots along dendrites in vitro neurons. Crebinostat can regulate chromatin mediated neuroplasticity and enhance memory in mice.

Specifications

Application area of Crebinostat

Mainly applied in the field of biopharmaceutical research and development, including:

• Neuroscience research: as a cognitive enhancer, used for mechanism research and drug screening of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD).
• Epigenetics research: used to study the role of histone acetylation modification in gene transcription regulation and chromatin remodeling.
• Neurodevelopment and Plasticity Study: In vitro cellular experiments aimed at promoting synaptic development and increasing dendritic spine density in neurons.

Main Advantages 

Multi target synergistic mechanism: Unlike single target drugs, Crebinostat can effectively inhibit HDAC1, 2, 3, and 6 simultaneously, synergistically enhancing neuroplasticity by regulating the acetylation levels of multiple substrates (such as histones and alpha microtubules).
Clear in vitro and in vivo pharmacological effects: Data shows that this raw material can significantly induce neuronal histone acetylation at low concentrations (nM level) and exhibit the ability to improve situational fear memory in animal models.
High purity and stability: The purity of the raw materials we supply has been rigorously tested (≥ 98%) and has chemical stability for up to 3 years under recommended storage conditions (-20 ° C drying), ensuring the reproducibility of experimental results.

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Why choose us

Choosing Faithful as your supply chain partner means choosing professionalism and peace of mind:

• Quality first: Our Crebinostat is over 98% with minimal impurities, making it a high-quality raw material for scientific research.
• Spot inventory, fast delivery: We have a mature warehousing system and Crebinostat raw materials are always in stock. Ship within 1-3 days after receiving the order.
• Multi channel transportation: We choose the appropriate transportation plan based on the destination country's transportation situation to ensure the safe delivery of products.

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FAQ

Q1:What solvents are suitable for Crebinostat powder?

A1:Crebinostat recommends using DMSO (dimethyl sulfoxide) as the preferred solvent. Insoluble in ethanol (EtOH) and also insoluble in water.

Q2:How to store the goods after receiving them? How long can it be stored?

A2:The original powder is sealed and stored in a dry state at -20 ° C. Under these conditions, the chemical stability of Crebinostat can be maintained for at least 3 years.

Q3:What is the mechanism of action of Crebinostat?

A3:It not only induces histone H3/H4 acetylation (regulating gene transcription), but the latest research also confirms that it can significantly enhance the acetylation of α - tubulin and reduce the level of HDAC6, which plays a key role in promoting memory formation.

Contact US

Accelerate your neuroscience research with outstanding Crebinostat, and look forward to exploring the boundaries of cognitive science with you. Pls contact sales1@faithfulbio.com if you need it.