NVP-BGJ398

Xi'an Faithful BioTech Co., Ltd: Your Trusted NVP-BGJ398 Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd supplies NVP-BGJ398. Our company was established in 2018 and specializes in supplying high-purity pharmaceutical intermediates and active pharmaceutical ingredients. Our annual supply capacity is over 200 kilograms. In the past three years, we have served over 150 domestic and foreign pharmaceutical companies and research institutions, with a customer repurchase rate of 90%. Our product purity is stable between 98% -99.5%, and we are committed to providing high-quality and traceable raw material supply services to global customers.

NVP-BGJ398 Introduction

NVP-BGJ398 is a highly selective FGFR1-3 oral tyrosine kinase inhibitor, belonging to the N-aryl-N-pyrimidin-4-ylurea class of small molecule targeted drugs. The raw material is a white to light yellow powder with a purity of over 98%. Its mechanism of action is to competitively bind to the ATP binding pocket of FGFR kinase domain, block self phosphorylation and downstream RAS/MAPK, PI3K/AKT signaling pathways, thereby inhibiting tumor cell proliferation and inducing apoptosis. Our raw materials have high purity and few impurities, making them high-quality materials for scientific research.

Specifications

Application area of NVP-BGJ398

1. Treatment of cholangiocarcinoma: Used for adult patients with unresectable locally advanced or metastatic FGFR2 gene fusion/rearrangement who have previously received treatment for cholangiocarcinoma.
2. Glioma treatment: Studies have shown that NVP-BGJ398 has therapeutic effects on recurrent glioma patients with FGFR point mutations and FGFR3 fusion, with some patients experiencing disease control lasting more than 1 year.
3. Treatment of bone growth disorders: Used to treat genetic bone growth diseases such as cartilage dysplasia, by inhibiting the overactive FGFR3 gene, promoting natural growth in children.
4. Other solid tumor research: Clinical trials are currently underway for advanced solid tumors related to FGFR gene mutations, such as gastric cancer, gastroesophageal junction adenocarcinoma, and urothelial carcinoma.

Main Advantages 

• Targeted Precision: Highly selective inhibition of FGFR1-3 with minimal impact on normal cells, and lower off target toxicity compared to traditional chemotherapy.
• Adequate clinical validation: FDA approved drug for market, global multicenter clinical trials validate its efficacy and safety.
• Mature synthesis process: The latest process has a total yield of 49.6% and a purity of 99.38%.
• Great potential for expanding indications: In addition to cholangiocarcinoma, it has shown good application prospects in fields such as glioma and bone development diseases.
• Clear market demand: The number of new cases of cholangiocarcinoma worldwide is still increasing each year, with FGFR2 gene abnormalities accounting for 14% -17%, indicating an urgent need for treatment.

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Why choose us

• Stable supply guarantee

Our company has a mature production supply chain system that can meet diverse procurement needs from gram to kilogram levels, ensuring a timely delivery rate of over 98% for orders.

• Flexible supply model

Support small batch trial orders and large-scale long-term procurement, and packaging specifications can be customized according to customer needs. For long-term cooperative customers, a framework agreement can be signed to lock in prices and supply quantities.

• Good market reputation

Since its establishment, we have served over 150 pharmaceutical companies and research institutions, with a customer repurchase rate of 90%. This is not only the recognition of our products by customers, but also the driving force for our continuous progress.

Quality Control

R&D Results

Packaging and Transportation

After-Sales Service

Qualification Certification

Exhibition

FAQ

Q1:What is the biological activity of NVP-BGJ398?

A1:BGJ398 (NVP-BGJ398) is an effective and selective FGFR inhibitor that acts on FGFR1/2/3, with an IC50 of 0.9nM/1.4nMChemicalbook/1nM. Its selectivity towards FGFR is more than 40 times higher than that towards FGFR4 and VEGFR2, and it has almost no inhibitory activity against Abl, Fyn, Kit, Lck, Lyn, and Yes.

Q2:Does BGJ398 raw material have a patent? Is it legal to use it for research and development?

A2:The core compound patent of BGJ398 is still in the patent protection period (expected to be around 2030). Our company clearly declares that all products are for industrial applications or scientific research only.

Q3:What is the purity of the BGJ398 raw material you supply?

A3:The purity of the raw materials supplied by our company for Infaglutinib is consistently controlled between 98% and 99.5%.

Contact US

We have high quality NVP-BGJ398 ，if you need it ， pls tell us  sales1@faithfulbio.com.