5'-Deoxy-5-Fluorocytidine

Xi'an Faithful BioTech Co., Ltd: Your Trusted 5'-Deoxy-5-Fluorocytidine Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd was founded in 2018, and we specialize in providing supply chain services for nucleoside antitumor drug intermediates. Our main products include 5'-Deoxy-5-Fluorocytidine and other fluoropyrimidine series. Since its establishment, we have served over 3000 clients in Europe, America, Australia, South Asia, the Middle East, and Africa.

5'-Deoxy-5-Fluorocytidine Introduction

5'-Deoxy-5-Fluorocytidine,It is the second to last intermediate in the synthesis of Capecitabine, obtained by condensation of 5-fluorocytosine with 5-deoxyribose, and further acylation to generate capecitabine. This compound contains a fluoropyrimidine ring and a deoxypentose structure, which is a key node in the design of oral prodrugs. The original powder is a white to off white crystalline powder.

Specifications

Application area of 5'-Deoxy-5-Fluorocytidine

• Capecitabine API synthesis and impurity control: It is a direct precursor for capecitabine API synthesis and can also be used for intermediate control and impurity mass spectrometry analysis.
• Development of generic drug process: Used in route optimization, process validation, and quality research of capecitabine generic drugs.
• New drug development: As the structural mother nucleus, it is conducive to designing new oral fluoropyrimidine based anti-tumor prodrug generic drugs.

Main Advantages

1. The process location is important: it is the final step in the synthesis route of capecitabine, and the purity of 5'-Deoxy-5-Fluorocytidine directly affects the final API yield.
2. Friendly storage conditions: No need for extreme low temperatures or special protection. Storage at 2-8 degrees is sufficient.
3. Typical specific rotation index: [α] D=+48 ° to+52 ° (c=1, MeOH), which facilitates rapid identification of optical purity.

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Why choose us

In stock supply, we have a stock of 5'-Deoxy-5-Fluorocytidine powder weighing over 20 kilograms, which can be arranged for shipment as soon as possible after placing an order;

Small packages are more flexible, with 50 grams for process validation, 500 grams for pilot testing, and 5 kilograms for registration batch, all of which we ship;

Rich export experience, with nearly 10 years of professional API export experience and stable transportation channels.

1. Quality Control

R&D Results

Packaging and Transportation

After-Sales Service

Qualification Certification

Exhibition

FAQ

Q1:What are the main impurities in 5'-Deoxy-5-Fluorocytidine?

A1: Residual 5-fluorocytosine from starting materials (should be ≤ 0.5%); The defluorination degradation products generated by the detachment of fluorine atoms in the process (should be ≤ 0.3%); Optical purity related isomers (HPLC should have main peak separation).

Q2:What is the relationship between 5'-Deoxy-5-Fluorocytidine and intermediate 4 (diacetate) of capecitabine?

A2: Intermediate 4 is the product of the glycosylation step, with two acetyl protecting groups; 5'-Deoxy-5-Fluorocytidine is located downstream of intermediate 4 and upstream of the capecitabine API.

Q3:Can capsules be directly filled?

A3:It is an intermediate, not an active pharmaceutical ingredient, and cannot be directly filled into capsules.

Contact US

 Welcome to inquiy sales1@faithfulbio.com .The final step in the production of capecitabine, we will take care of it for you —— high quality 5'-Deoxy-5-Fluorocytidine.