Apixaban API

Product Name:Apixaban API
CAS NO.:503612-47-3
Molecular formula:C25H25N5O4
EINECS:639-684-6
Synonyms:Apixaban
Purity : 98% HPLC
Certificate:COA; HPLC; MSDS; TDS,etc.
MOQ : 100g
Shipping: DHL/FedEx/UPS/USPS Safe and fast delivery
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse

Product Description

Xi'an Faithful BioTech Co., Ltd: Your Trusted Apixaban API Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd specializes in specialty active pharmaceutical ingredients such as Apixaban API, focusing on the supply of high-quality pharmaceutical raw materials and intermediates, providing stable and compliant Edoxaban for pharmaceutical companies, and helping customers achieve value transformation from research and development to commercialization.

Apixaban API Introduction

Apixaban API belongs to the class of oral active calcium-sensitive receptor (CaSR) allosteric agonists, a small molecule API. It is an orally administered, potent, and highly selective factor Xa inhibitor. Apixaban API is a white to off-white crystalline powder, belonging to the BCS class III drugs. As a direct factor Xa inhibitor, apixaban's anticoagulant effect is independent of antithrombin III, simultaneously inhibiting both free and thrombus-bound FXa, exerting its anticoagulant effect by reducing thrombin production. It is primarily used in the production of imported tablets for chronic kidney disease with secondary hyperparathyroidism during dialysis, and is also suitable for endocrine and metabolic pharmacological research, representing a new generation of core pharmaceutical raw materials for regulating mineral metabolism in kidney disease.

Specifications

Item	Specification	Result
Appearance	White to off-white powder	White powder
Loss on drying	≤2.0%	0.08%
Residue on ignition	≤0.1%	0.05%
Heavy Metal	≤20ppm	Conforms
Assay(HPLC)	≥98.0%	99.21%
Conclusion	Complies with In-house standard

Application area of Apixaban API

Apixaban API is primarily used in the production of oral solid dosage forms and is suitable for the following clinical scenarios:

Stroke prevention in patients with nonvalvular atrial fibrillation: Used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
Postoperative venous thrombosis prevention in orthopedic patients: Used to prevent deep vein thrombosis and its potential pulmonary embolism in patients undergoing hip or knee replacement surgery.
Treatment of venous thromboembolism: Used to treat DVT and PE, and to reduce the risk of recurrence of DVT and PE after initial treatment.

Main Advantages

Apixaban undergoes multiple rounds of refining and purification, resulting in trace impurities levels far below the pharmacopoeia limits. It exhibits high chiral purity and does not produce ineffective antagonistic impurities, directly meeting the stringent review standards for generic drug applications. Apixaban API crystals have uniform particle size, excellent flowability, and superior compatibility with tablet excipients such as lactose and microcrystalline cellulose. It is less prone to sticking and delamination during tableting, demonstrating strong processing adaptability. As a selective factor Xa inhibitor, it has specific action, minimal interference with normal coagulation balance, and a lower risk of bleeding compared to traditional anticoagulant raw materials, resulting in superior safety in the finished product.

Why choose us

As your upstream partner, our first commitment is quality. Our Apixaban API is produced under strict production conditions, and key indicators such as content and related substances (individual impurities<0.1%) meet the requirements of the International Pharmacopoeia.
Secondly, with stable supply and deep cooperation with core production enterprises, Edoxaban powder has a year-round inventory of spot goods, which can be shipped out as soon as possible after placing an order, without the need for long waiting times.