Bedaquiline fumarate

Xi'an Faithful BioTech Co., Ltd: Your Trusted Bedaquiline fumarate Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd provides high-quality Bedaquiline fumarate. We are a high-tech enterprise dedicated to the research and development, production, and export sales of high value-added active pharmaceutical ingredients and pharmaceutical intermediates. Faithful was founded in 2018 and has nearly 10 years of industry experience. Our products are exported to more than 20 countries and regions including North America, Europe, Southeast Asia, and Central and South America.

Bedaquiline fumarate Introduction

Bedaquiline fumarate， It is a type of diarylquinoline anti mycobacterial drug that selectively inhibits the ATP synthase of Mycobacterium tuberculosis, blocks bacterial energy metabolism, and leads to its death. This compound is a white to off white powder with a purity of ≥ 99% and extremely high selectivity (selectivity index>20000), with minimal impact on human ATP synthase. It is mainly used as a combination therapy for multidrug-resistant tuberculosis (MDR-TB) and is one of the core drugs recommended by WHO.

Specifications

Application area of Bedaquiline fumarate

1. Multidrug resistant tuberculosis (MDR-TB) treatment: As the core drug of combination therapy, it is suitable for the treatment of multidrug-resistant tuberculosis in adults and adolescents over 12 years old with a body weight of ≥ 30kg.
2. Scientific drug research: used for pharmacokinetic studies, formulation development (such as liposome encapsulation technology), and evaluation of anti tuberculosis activity in animal models.
3. Drug sensitivity testing: used for in vitro drug sensitivity testing of clinically isolated strains to evaluate the drug response of Mycobacterium tuberculosis.

Main Advantages

• Unique mechanism of action: targeting ATP synthase, without cross resistance with existing anti tuberculosis drugs, maintaining excellent inhibitory activity against multiple drug-resistant strains (MIC value 0.125-0.5mg/L).
• High selectivity and good safety: The selectivity index for human ATP synthase exceeds 20000, the treatment window is wide, and adverse reactions are controllable.
• Excellent pharmacokinetics: with an extremely long terminal elimination half-life (approximately 5.5 months), ensuring sustained in vivo exposure levels and stable antibacterial concentrations.
• Flexible compatibility of dosage forms: It can be developed into various dosage forms such as oral tablets or injectable liposomes to meet different clinical needs.
• Accurate efficacy: Bedaquiline fumarate, as a core drug recommended by WHO, has been included in the standard treatment regimen for multidrug-resistant tuberculosis by guidelines from multiple countries worldwide.

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Why choose us

We insist on providing HPLC purity testing reports (≥ 99%), moisture content analysis, and heavy metal detection data for each batch of products. The product meets the standards of export enterprises and supports customers to entrust third-party institutions for re inspection to ensure transparent and traceable quality; On the premise of ensuring a high purity of over 99%, provide a quote that is better than the market average price. Support 1kg sample trial order, 15kg cardboard drum standard packaging, flexible payment methods; The core product has sufficient regular inventory and can be shipped in a timely manner.

1. Quality Control

R&D Results

Packaging and Transportation

After-Sales Service

Qualification Certification

Exhibition

FAQ

Q1:What is the solubility of Bedaquiline fumarate?

A1:The solubility in DMSO is 2 mg/mL, which can form a clear solution. If a higher concentration is required, it is recommended to dissolve it with appropriate heating or ultrasound assistance.

Q2:What is the purity of the product? Can you provide a testing report?

A2:Our product has an HPLC purity of ≥ 99%, and each batch comes with a COA (Certificate of Analysis) containing indicators such as purity, moisture, and heavy metals, supporting customer retesting.

Q3:What is the difference between Bedaquiline fumarate and Bedaquiline bases?

A3: Fumarate salt is a salt form formed by the combination of bedaquiline and fumaric acid, which has better water solubility and stability, higher bioavailability, and is currently the mainstream choice for formulation development.

Contact US

Choosing us means choosing 99% Bedaquiline fumarate guarantee and worry free professional services throughout the process.Pls send message to sales1@faithfulbio.com if you need.