Benazepril hydrochloride API
CAS.NO:86541-74-4
structural formula:C24H29ClN2O5
EINECS.no:630-414-2
Other names:CGS 14824A HCl;Lotensin;Benazepril hydrochloride;cgs14824a
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Benazepril hydrochloride API Manufacturer & Supplier
Benazepril hydrochloride API is an inhibitor of angiotensin-converting enzyme, which can inhibit the conversion of angiotensin 1 to angiotensin II, leading to a decrease in angiotensin II production, vasodilation, and lowering blood pressure. In addition, the Benazepril HCl raw material provided by Xi'an Faithful BioTech Co., Ltd Company can inhibit the activation of RASS system, improve the ventricular remodeling, and inhibit the secretion of aldosterone, which reduces the retention of water and sodium, and also plays a role in reducing blood pressure.
Benazepril hydrochloride API Introduction
Benazepril hydrochloride API can be used as an adjuvant therapy for patients with hypertension, congestive heart failure, and congestive heart failure who do not respond well to certain raw materials. Research has shown that Benazepril, as an angiotensin-converting enzyme inhibitor, can reduce various effects mediated by angiotensin II by inhibiting the activity of angiotensin-converting enzyme, thereby reducing peripheral vascular resistance and further alleviating a series of symptoms caused by angiotensin (such as elevated blood pressure, increased excitatory heart rate due to vasodilation, and insufficient cardiac output). After clinical application, you can find that the Benazepril HCl powder provided by us does not cause compensatory fluid retention while reducing blood pressure; While reducing ventricular afterload, it does not increase heart rate and can improve left ventricular hypertrophy and diabetes glucose tolerance.
Specifications
Item | Specifications | Results |
Appearance | White or creamy white crystalline powder | Conform |
Identification | Infrared Absorpion | Positive |
Water | ≤3.5% | 0.79% |
Loss on drying | ≤0.5% | 0.16% |
Related substances | any individual impurity ≤0 . 5% total impurities ≤ 1 . 0 % | Pass |
Residual solvents | propyl alcohol < 0.5% | Pass |
Burning residue | ≤0.2% | 0.18 % |
Sulphated ash | ≤0.1% | 0.1% |
Particle size | 60 -40 mesh | Pass |
Assay | 97.0 ~ 103.0% | 99.3% |
Heavy metals (as Pb) | ≤5ppm | ＜2.38 |
Total Plate Count | <10000cfu/g | 1320cfu/g |
Yeast and Mould | <100cfu/g | <10cfu/g |
E.Coli | Negative/10g | Negative |
Salmonella | Negative/ 10g | Negative |
| Conclusion | Conform with enterprise specification （USP 41）. |
Why Choose Us?
Our Benazepril Hydrochloride API raw material is selected because its purity is ≥99.0%, impurity content is strictly controlled within 1.0%, single impurity is less than 0.5%, endotoxin is ≤50EU/mg, and all quality indexes meet the international pharmacopoeia standards such as CP, USP, BP and EP. We adopt advanced production technology, which has passed the international authoritative certification such as FDA and EDQM, and meets the regulatory requirements of major markets around the world. In addition, each batch of our products is provided with a complete certificate of analysis (COA) to ensure that every link from raw material procurement to finished product delivery meets the requirements of good manufacturing practice (GMP).
Our email address is:sales8@faithfulbio.com, Welcome your letter.
Side effect
The side effects of benazepril hydrochloride api powder mainly manifest in the following aspects: 1. Common adverse reactions in the gastrointestinal system, such as vomiting, nausea, and other gastrointestinal reactions. 2. The nervous system can also have common adverse reactions, such as dizziness, headache, and other neurological adverse reactions. 3. Special adverse reactions, such as coughing, are believed by the medical community to contain substances that may affect cough, clinically known as bradykinin, which affects bradykinin and leads to coughing. In addition, it may also lead to vascular edema, such as causing swelling of the face, lips, tongue, glottis, or larynx in patients. If the above situation occurs, please pay attention. In addition, attention should be paid to monitoring blood potassium in daily applications, as it and similar products may cause an increase in blood potassium and have a potassium preserving effect.
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FAQ
Q1: How effective is its voltage reduction?
Clinical studies have shown that the Benazepril Hydrochloride API can significantly reduce blood pressure levels in patients with hypertension. Individually used therapy can reduce glycated hemoglobin (HbA1c) by 0.8% -1.5% and fasting blood glucose by 31.03mg/dL. In a spontaneously hypertensive rat model, it dose dependently inhibits the elevation of blood pressure caused by norepinephrine and suppresses epilepsy induced by monoamine oxidase inhibitors.
Q2: What additional benefits does it have?
In addition to its antihypertensive effect, Benazepril also has the following benefits: 1) improving heart function, increasing cardiac output, and prolonging exercise tolerance and duration; 2) Delay the progression of diabetes nephropathy and reduce proteinuria; 3) Reduce triglyceride and total cholesterol levels; 4) In cholesterol fed rabbits, aortic atherosclerosis was significantly reduced; 5) In animal models of chronic renal failure, significant reductions in blood pressure, angiotensin II, and aldosterone levels were observed.
Q3: What are the quality standards for Benazepril Hydrochloride API raw materials?
Raw materials must comply with international pharmacopoeia standards such as CP, USP, BP, EP, etc. The main quality indicators of the Benazepril HCl raw material powder we provide include: content ≥ 98% (calculated as dry product), related substances ≤ 1.0% (single impurity ≤ 0.5%), drying loss ≤ 1.0%, ignition residue ≤ 0.1%, and heavy metals ≤ 10ppm.
Contact us
Our Benazepril hydrochloride API raw materials are more competitive in price and have significant cost-effectiveness advantages, making them an ideal choice for researching the development of hypertension treatment. If you have any relevant procurement plans, please contact us via email:sales8@faithfulbio.com .
