Betahistine dihydrochloride API

Xi'an Faithful BioTech Co., Ltd: Your Trusted Betahistine dihydrochloride API Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd. supplies key intermediates and raw materials. Betahistine dihydrochloride API is our flagship product. Since its inception, we have adhered to the business philosophy of flexible response, stable delivery, and strict confidentiality, serving high-quality customers in more than 20 regions worldwide. Our customer repurchase rate remains consistently above 85% throughout the year.

Betahistine HCl Introduction

Betahistine dihydrochloride API is a white or off-white crystalline powder, chemically named N-methyl-2-(pyridin-2-yl)ethylamine dihydrochloride, with the molecular formula C₈H₁₂N₂·2HCl and a molecular weight of 209.12. It is an orally effective weak agonist of histamine H1 receptors and an antagonist of H3 receptors. As a histamine analog, it exerts its anti-vertigo effect by increasing inner ear microcirculation and regulating vestibular neuron activity, and has been used clinically since 1968. It exhibits excellent water solubility and stable physicochemical properties, making it a specialized pharmaceutical raw material for clinical vertigo preparations. Prepared using mature synthetic processes with strict control over impurities, it has been a core raw material for Class A drugs covered by medical insurance and is widely available in the pharmaceutical raw material market.

Specifications

Application area of ​​Betahistine HCl

Betahistine dihydrochloride API is primarily used in pharmaceutical manufacturing, specifically for the following purposes:

• Treatment of Meniere's disease and related vertigo: As a core treatment, it alleviates symptoms such as vertigo, tinnitus, and hearing loss caused by Meniere's disease by increasing cochlear and vestibular blood flow and reducing inner ear lymphedema.
• Treatment of benign paroxysmal positional vertigo (BPPV): Clinical studies have confirmed that betahistine hydrochloride effectively improves vertigo symptoms in BPPV patients, with a total improvement rate of 63.33%. Some studies show that daily doses of 32 mg or higher have a clear therapeutic effect and improve quality of life in patients with recurrent or persistent BPPV.
• Relief of vertigo-related accompanying symptoms: It improves vertigo-related symptoms such as nausea and vomiting, with clinical studies showing an improvement rate of up to 70%.
• Central and peripheral vestibular disorders: Used to treat vertigo associated with various peripheral and central vestibular disorders, and also has a certain therapeutic effect on motion sickness.

Main Advantages

As a dual-action drug, acting as both a weak H1 receptor agonist and an H3 receptor antagonist, it exerts a synergistic effect by dilating the inner ear microcirculation (increasing blood flow to the cochlea and vestibule) and inhibiting abnormal discharges of vestibular neurons. It has a significant vasodilatory effect on cerebrovascular and cardiovascular systems, particularly the vertebrobasilar artery system, significantly increasing blood flow to the heart, brain, and peripheral circulation, thus improving overall blood circulation. The raw material selectively acts on the microcirculatory receptors of the inner ear and brain, resulting in fewer side effects in the finished product. It has a broad clinical applicability, excellent raw material storage stability, and a sufficient shelf life under compliant moisture-proof storage conditions, making it suitable for both large-scale mass production and small-batch pilot production.

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Why choose us

We ensure that the raw materials of Betahistine dihydrochloride API and its intermediate 2-Cyclopropoxyethanol are produced strictly in accordance with a high standard internal control system, support third-party review, and implement full process monitoring of key impurities. At the same time, we have stable production capacity and flexible stocking mechanism, which can cover multi-stage needs from research and development to commercialization, eliminating the risk of supply interruption. In addition, we adhere to service boundaries, focus on raw material quality control and delivery execution, ensure transparent and predictable quality, delivery time, and terms, and strictly keep customer information confidential, winning trust with professionalism and professionalism.

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FAQ

Q1: Can I order a sample of the product before placing a larger order?

A1: Sample quantities are available for evaluation and testing purposes.

Q2: Is it suitable for long-term projects?

A2: Yes. Stable quality and supply make it suitable for ongoing development work.

Q3: Can technical documents be provided before purchase?

A3: Available product information and quality documents can be shared upon request.

Contact US

Professional supply of Betahistine dihydrochloride API raw materials, welcome to inquiry allen@faithful bio.com.