Calcium dobesilate powder
CAS.NO:20123-80-2
structural formula:2C6H5O5S.Ca
EINECS.no:243-531-5
Other names:dexium;doxium;CALCIUM DOBESILATE;Calcium Dobesilate Mnohydrate;Calcium dobesilate
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Calcium dobesilate powder Manufacturer & Supplier
Calcium dobesilate powder is a vasodilator that selectively acts on the walls of capillaries. It can adjust and improve the permeability and fragility of capillary walls, as well as inhibit active substances such as bradykinin In clinical practice, Calcium dobesilate provided by Xi'an Faithful BioTech Co., Ltd Company is mainly used to treat capillary diseases caused by various reasons. For example, common causes include but are not limited to: diabetes retinopathy, varicose veins, phlebitis, leg spasm, phlegmatic dermatitis, etc. It has high bioavailability, low toxicity, and high therapeutic index, and is currently an ideal pharmaceutical raw material for treating capillaries.
Calcium dobesilate powder Introduction
1. Calcium dobesilate has the ability to inhibit the high permeability caused by vasoactive substances (such as histamine, serotonin hydrochloride, hyaluronidase, Prostaglandin E2, etc.) on microvessels, reduce vascular intimal damage, improve the biosynthesis of basement membrane collagen, improve capillary wall permeability, increase red blood cell flexibility, reduce blood viscosity, improve lymphatic reflux, and thus reduce pathological high permeability of microvascular walls.
2. It can reduce the levels of fibrinogen and globulin, decrease the high aggregation of red blood cells, activate fibrinogen activity, increase the solubility of blood fibrinogen, and thus reduce blood viscosity. Reduce the synthesis and release of platelet aggregation factors, inhibit multiple aggregation factors, cause aggregation reactions and spontaneous platelet aggregation, lower platelet activity, and prevent thrombosis.
3. For microvascular lesions, Calcium dobesilate powder can increase the caliber of arterioles and venules, increase the number of open capillaries, significantly accelerate blood flow velocity, and significantly improve microcirculation. Eliminate or alleviate various problems caused by microcirculation, such as edema, capillary exudation, lower limb heaviness, and pressure sensation.
4. It can significantly reduce the content of Sorbitol, block sugar transport channels, and inhibit the functional impairment caused by the increase of sorbitol active molecules in blood cells.
Specifications
Item | Specifications | Results |
Physical Analysis |
|
|
Description | White to beige hygroscopic powder | Complies |
Assay | ≥ 99% | 99.12% |
Ash | ≤ 5.0% | 2.85% |
Loss on Drying | ≤ 5.0% | 2.82% |
Chemical Analysis |
|
|
Heavy Metal | ≤ 10.0 mg/kg | Complies |
Pb | ≤ 2.0 mg/kg | Complies |
As | ≤ 1.0 mg/kg | Complies |
Hg | ≤ 0.1 mg/kg | Complies |
Microbiological Analysis |
|
|
Residue of Pesticide | Negative | Negative |
Total Plate Count | ≤ 1000cfu/g | Complies |
Yeast&Mold | ≤ 100cfu/g | Complies |
E.coil | Negative | Negative |
Salmonella | Negative | Negative |
| Conclusion | Conform with enterprise specification （USP 41）. |
Why Choose Us?
Choose our calcium dobesilate powder because the product purity is ≥ 98.5%, the impurity content is strictly controlled within 1.0%, the single impurity is less than 0.5%, the biological activity is ≥ 80.0%, the endotoxin is ≤ 50EU/mg, and all quality indicators meet international pharmacopoeia standards such as CP, USP, BP, EP, etc. We adopt advanced production processes and our products have passed international authoritative certifications such as FDA and EDQM, meeting the regulatory requirements of major global markets. Each batch of products comes with a complete Certificate of Analysis (COA) to ensure that every step from raw material procurement to finished product delivery complies with Good Manufacturing Practice (GMP) requirements.Our email address is:sales8@faithfulbio.com, Welcome your letter.
Side effect
Even if calcium dobesilate is well tolerated after long-term use, allergic reactions cannot be ruled out. Occasionally, if there are symptoms such as stomach discomfort, nausea, heartburn, and decreased appetite, the dosage should be reduced appropriately, and if necessary, the use should be immediately discontinued.
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FAQ
Q1: What are the quality standards for active pharmaceutical ingredients Calcium dobesilate APIs powder ?
Core indicator: Content ≥ 99.0% (calculated as dry product); Related substances ≤ 1.0% (single impurity ≤ 0.5%); Dry weight loss ≤ 1.0%; Burning residue ≤ 0.1%; Heavy metals ≤ 10ppm; The calcium content (by titration method) should be 8.0%~9.0% (theoretical value 8.57%). Must comply with international pharmacopoeial standards such as CP, USP, EP, etc.
Q2: How are substances detected?
The standard detection wavelength is 225nm using high-performance liquid chromatography (HPLC). The retention time of the main peak is about 8 minutes, and the separation degree from adjacent impurity peaks is ≥ 1.5; The peak area of a single impurity is ≤ 0.5%, and the total impurity is ≤ 1.0%.
Q3: Which Pharmaceutical raw materials interact with it?
It is used in combination with anticoagulants: it may enhance the anticoagulant effect and requires monitoring of INR;
It is used in combination with vitamin C: synergistically antioxidant, but does not affect mutual absorption;
It is used in combination with insulin/hypoglycemic drugs: it does not affect blood glucose, but diabetes nephropathy patients need to monitor blood glucose fluctuations.
Q4: Storage conditions and packaging specifications?
Storage: Light shielded, sealed, stored in a cool and dry place (≤ 25 ℃) to avoid moisture;
Packaging: Raw materials are commonly packaged in 1kg/aluminum foil bags, 5kg/cardboard drums, or 25kg/plastic drums, supporting different specifications of packaging.
Contact us
Compared with similar pharmaceutical raw materials (such as Rutin powder), Calcium dobesilate powder has the following advantages: ① high bioavailability (completely absorbed by the body, no first pass effect); ② Strong targeting (directly acting on the endothelium of capillaries, improving microcirculation more accurately); ③ Good safety (adverse reaction rate<5%, no severe liver toxicity). If you wish to conduct further research on this product, please contact us via email:sales8@faithfulbio.com.
