Doxazosin Mesylate API

Xi'an Faithful BioTech Co., Ltd: Your Trusted Doxazosin Mesylate API Manufacturer & Supplier

Doxazosin mesylate api powder is a selective postsynaptic α 1-adrenergic receptor blocker that dilates blood vessels, reduces vascular resistance, and lowers blood pressure by blocking α 1-adrenergic receptors. In addition, it can improve the urodynamics and clinical symptoms of symptomatic prostate hyperplasia patients by selectively blocking the alpha adrenergic receptors in the prostate smooth muscle matrix and bladder neck. The Doxazosin Mesylate provided by Xi'an Faithful BioTech Co., Ltd has a longer half-life than the first generation and is currently the preferred choice for the treatment of benign prostatic hyperplasia and hypertension in clinical practice.

Doxazosin Mesylate API Introduction

Doxazosin Mesylate API is a selective α 1 receptor inhibitor that acts by blocking the a1 receptor to dilate blood vessels, reduce vascular resistance, and lower blood pressure. In addition, in the human body, it can also counteract prostate contraction caused by alpha 1 receptor agonists and reduce peripheral vascular resistance to lower prostate inflammation. According to relevant research, symptoms associated with benign prostatic hyperplasia (BPH), such as frequent urination, increased nocturia, thin and weak urine stream, hesitancy during urination, and incomplete urination, are all related to two factors: the anatomical structure of the prostate (static factor) and its function (dynamic factor). The static factors of benign prostatic hyperplasia are related to prostate enlargement, which is to some extent caused by the proliferation of prostatic stromal smooth muscle cells. However, the severity of symptoms of benign prostatic hyperplasia and the degree of urethral obstruction are not entirely related to the size of the prostate. The dynamic factors of benign prostatic hyperplasia are related to increased smooth muscle tension in the prostate and bladder neck, which is mediated by α 1 receptors. α 1 receptors are highly expressed in the prostate stroma, prostate capsule, and bladder neck. The effect of doxazosin on inhibiting alpha 1 receptors is to reduce urethral resistance and alleviate symptoms of benign prostatic hyperplasia.

Specifications

Why Choose Us? 

1、 Excellent quality
The purity of the active pharmaceutical ingredient of doxazosin mesylate produced by us is over 99.5%, strictly complying with international pharmacopoeia standards such as CP2015, USP38, BP2012, etc. It undergoes multiple tests such as HPLC, UV, TLC, etc. to ensure that the relevant substances are ≤ 1.0%, drying loss is ≤ 1.0%, ignition residue is ≤ 0.1%, and heavy metals are ≤ 10ppm, providing reliable quality assurance for your formulation production.
2、 Advanced synthesis technology
We adopt an optimized four step synthesis process, which significantly shortens the production process compared to the traditional six step process, and the yield can reach over 90%. By using a combination of highly polar solvents/poor solvents for purification, Ensure that its crystal form is stable and the DSC peak shape is good, meeting the requirements for the F crystal structure. The process conditions are mild, the operation is simple, and the production cost and "three wastes" emissions are significantly reduced.
3、 Stable supply capacity
We have modern production equipment and strict quality management system, with an annual production capacity of over 52000 kilograms, which can meet the bulk demand of domestic and foreign markets. The doxazosin mesylate raw powder is packaged in standard 25kg cardboard drums, and can also be customized with small packaging according to customer requirements, supporting fast shipping and global export.
4、 Professional service support
We provide complete technical information and quality analysis reports, support sample application and customized services. A professional sales and technical team can respond to your needs in a timely manner, providing comprehensive services from product consultation to after-sales tracking, ensuring smooth and efficient cooperation.
Choosing us means choosing the perfect combination of quality, technology, and service! My email is: sales8@faithfulbio.com ,Welcome to the store for inquiries.

Adverse effects on sexual function?

Doxazosin mesylate API powder has certain influence on sexual function, but the degree of influence varies from person to person. According to clinical statistics, its specific effects on sexual function are as follows:
1. Erectile dysfunction: A few patients may have difficulty in erection or maintenance, and the incidence rate is usually lower than 2%-5%. This is mainly due to the local blood flow reduction caused by drug dilating blood vessels, which indirectly affects erectile function.
2. Abnormal ejaculation: There may be decreased ejaculation or retrograde ejaculation (semen flows into the bladder instead of being excreted), which is related to the effect of drugs on bladder neck muscle relaxation.
3. Decreased libido: Some patients may have decreased libido, which may be indirectly related to systemic reactions such as fatigue and dizziness caused by Its side effects.

But, it should be noted that, first of all, these side effects will not occur in all patients, and can basically be gradually recovered by adjusting the use of DOXAZOSIN METHANESULFONATE; Secondly, hypertension and prostate diseases themselves may also lead to sexual dysfunction, which needs to be comprehensively judged in combination with various situations; Finally, whether there are persistent sexual problems or occasional sexual problems, you should seek medical evaluation in time, and maintaining a healthy lifestyle will help reduce the risk of side effects.

Quality Control:

Packaging and Transportation:

After-Sales Service: 

Qualification Certification:

Transaction Feedback: 

Exhibition: 

Contact us

We adopted an optimized synthesis process to shorten the traditional six-step reaction to four steps, and the Doxazosin mesylate raw API powder yield was over 90%, and the purity was ≥99%, which met the USP/EP/CP Pharmacopoeia standard. Each batch of Doxazosin Mesylate has been strictly tested by HPLC and GC-MS to ensure that the related substances are ≤1.0%, heavy metals are ≤10ppm, and the residual solvents meet ICH standards. If you are interested in it, please leave a message to me through email (my email:sales8@faithfulbio.com).