Glibenclamide API powder
CAS.NO:10238-21-8
structural formula:C23H28ClN3O5S
EINECS.no:233-570-6
Other names:Glibenclamide;Glibenclamide Bp;GLYBURIDE USP;GLYBURIDE;GIBENCLAMIDE;GLIBENCLAMIDE;GLYBENCLAMIDE;GLYBENZCYCLAMIDE
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Glibenclamide API powder Manufacturer & Supplier
Glibenclamide API powder is a second-generation sulfonylurea hypoglycemic pharmaceutical raw material, which selectively acts on islet B cells, promotes insulin secretion, and can also correct insulin resistance in peripheral tissues of patients with type 2 diabetes. According to the relevant clinical data, the API glibenclamide Raw powder provided by Xi'an Faithful BioTech Co., Ltd company is like putting a protective armor on the body's large blood vessels and capillaries, which can significantly reduce the risk of complications of large blood vessels and capillaries caused by diabetes. For those patients with type 2 diabetes whose islet function has not been completely lost, it will bring new hope and possibility.
Glibenclamide API powder Introduction
Glibenclamide is a white crystalline powder. Clinical studies have found that it can exert hypoglycemic effects by stimulating pancreatic beta cells to secrete insulin. Its mechanism of action is to specifically bind to sulfonylurea receptors on the beta cell membrane, close ATP dependent potassium ion channels, cause depolarization of the cell membrane, open calcium ion channels, increase intracellular calcium ion concentration, and promote insulin secretion. In addition, glibenclamide API Powder can inhibit hepatic glycogen breakdown and gluconeogenesis, reduce hepatic glucose production, and enhance peripheral tissue sensitivity to insulin, promoting glucose uptake and utilization.
Specifications
Item | Specifications | Results |
Appearance | White powder | Conform |
Resisues after Ignition | ≤ 0.1% | 0.06% |
Melting Point | 173-175°C | 274°C |
Loss on Drying | ≤1% | 0.42% |
Assay | ≥98.0% | 98.15% |
Heavy Metal(Hg) | ≤ 1ppm | 0.028 ppm |
Total Plate Count | ≤ 1000 cfu/g | 2.38 cfu/g |
Yeasts and Moulds | ≤ 100 cfu/g | 0.38 |
E.coli | Negative | Complies |
Salmonella | Negative | Complies |
| Conclusion | Conform with enterprise specification （USP 41）. |
Why Choose Us?
Choosing our glibenclamide raw material is a classic scheme with clear mechanism and remarkable hypoglycemic effect, which has been verified by clinical application for decades. As a second-generation sulfonylurea hypoglycemic agent, it provides a stable pharmacodynamic basis for the development of pharmaceutical preparations. Although it needs to be used under the strict guidance of doctors as a raw material for prescription drugs, and attention should be paid to the risks such as hypoglycemia, glibenclamide API powder is still a reliable choice for the research and development and production of efficient and classic hypoglycemic ingredients.
In addition to glibenclamide, we also have other types of hot-selling hypoglycemic raw materials, with their respective mechanisms of action and applicable scenarios to meet different product development needs:
Metformin: As the most classic first-line hypoglycemic agent in the world, it mainly reduces blood sugar by inhibiting liver gluconeogenesis and improving peripheral insulin sensitivity, especially for patients with type 2 diabetes and obesity, with a good safety record.
Berberine: an alkaloid extracted from plants and called "plant metformin". It can improve insulin resistance and regulate intestinal flora by activating AMPK signaling pathway, and has an auxiliary control effect on fasting and postprandial blood sugar.
Ergothioneine/NMN (β-Nicotinamide Mononucleotide): These two are new raw materials in the field of dietary supplements. L-(+)-ERGOTHIONEINE INNER SALT with its strong antioxidant activity, has attracted much attention in protecting islet β cells and alleviating oxidative stress damage. NMN, as the precursor of NAD+, can help regulate blood sugar by improving the level of energy metabolism of cells and improving the overall metabolic function.
Alpha-Lipoic Acid/Chromium Picolinate: It is a nutritional supplement raw material. α -lipoic acid is a powerful antioxidant, which is helpful to improve diabetic neuropathy; Chromium is a component of glucose tolerance factor, and supplementing chromium picolinate is helpful to improve insulin sensitivity.
If you want to compare and analyze the development feasibility of one of the raw materials (such as emerging Ergothioneine or classic metformin), I can provide you with more detailed information.
Our email address is:sales8@faithfulbio.com, Welcome your letter.
Side effect
In 2003, Glibenclamide powder was the most popular hypoglycemic material in the United States. In 2007, it was also one of the two main hypoglycemic products recommended by the World Health Organization Pharmacopoeia, but it was gradually abandoned due to drug resistance and side effects.
1. Its common adverse reactions include diarrhea, nausea, vomiting, headache, stomachache or discomfort; Less common is a rash; Rare and serious cases include jaundice, liver function damage, bone marrow suppression, granulocytopenia (manifested as sore throat, fever and infection), thrombocytopenia (manifested as bleeding and purpura) and so on. Among them, hypoglycemia reaction is the most common and needs special attention.
2. Its serious adverse reactions include: hypoglycemia, which can lead to coma, seizure and even death in severe cases; Liver function damage, manifested as jaundice and elevated transaminase; Blood system reactions, such as granulocytopenia, thrombocytopenia, aplastic anemia; Allergic reactions, such as exfoliative dermatitis. If the above symptoms appear, you should stop taking medicine immediately and seek medical advice.
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FAQ
Q1: Will it become ineffective if used for a long time?
Long term use of glibenclamide may result in secondary failure. After ruling out factors such as improper dosage, lack of dietary and exercise control, secondary failure of glibenclamide should be considered and its use should be discontinued. It is recommended to switch to other hypoglycemic drugs (such as insulin) for treatment.
Q2: What is the onset time and duration of action of glibenclamide?
Its absorption is fast, and clinical studies have found that its protein binding rate is as high as 95%. The blood drug concentration reaches its peak 2-5 hours after use, and it continues to act for 24 hours with a half-life of 10 hours. Metabolized in the liver, approximately 50% is excreted by the liver and 50% by the kidneys.
Q3: How is glibenclamide stored?
Store in a dark, sealed, and room temperature environment, with a temperature below 30 ℃ to avoid high temperatures or freezing. Keep away from moisture and do not store in damp environments such as bathrooms. At the same time, after using it, we recommend that it should always be stored in its original packaging to avoid being divided into other containers, and the packaging should be sealed immediately after each use.
Contact us
Our raw material of API glibenclamide was chosen because the purity of our products was ≥98.5%, which met the international pharmacopoeia standards such as CP, USP, BP, EP, etc., and had passed the FDA and EDQM certification, and had the qualification of global market access, and the price was more competitive. If you are interested, please contact us by email:sales8@faithfulbio.com .
