Macitentan API
CAS NO.:441798-33-0
Molecular formula:C19H20Br2N6O4S
EINECS:1308068-626-2
Synonyms:N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide
Purity : 99% HPLC
Certificate:COA; HPLC; MSDS; TDS,etc.
MOQ : 100g
Shipping: DHL/FedEx/UPS/USPS Safe and fast delivery
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Macitentan API Manufacturer & Supplier
Xi'an Faithful BioTech Co., Ltd focuses on supplying the full chain raw materials of Macitentan API, a pulmonary arterial hypertension treatment drug, and is committed to providing high-purity and high inter batch consistency raw materials for global pharmaceutical companies.
Macitentan API Introduction
Macitentan API (CAS: 441798-33-0) is a non chiral sulfonamide derivative. It is a novel orally active dual endothelin receptor antagonist that inhibits vascular constriction and pathological remodeling mediated by endothelin-1 by blocking ETA and ETB receptors with high affinity and persistence. It can significantly reduce the incidence rate and mortality of PAH patients.
Specifications
Items | Specification | Result |
| Appearance | off white to light yellow powder | Complies |
| Residue on ignition | ≤ 0.2% | 0.07% |
| Single impurity | ≤0.5% | 0.24% |
| Water | ≤ 0.5% | 0.17% |
| Assay | ≥99.0% | 99.62% |
Conclusion: | This batch product conform to the requirements. | |
Application area of Macitentan API
- Pulmonary arterial hypertension (PAH): Used alone or in combination with PDE-5 inhibitors, it delays the progression of PAH disease, reduces hospitalization rates, and improves long-term prognosis.
- Compound preparation: A single tablet compound made with Tadalafil provides a more convenient medication plan for the combined treatment of PAH.
- Research and development of generic drugs for rare diseases: As an essential raw material for the treatment of PAH, it is a core raw material variety for generic drug companies and global pharmaceutical export trade.
- High end formulations: can industrialize the production of various dosage forms such as oral film coated tablets and dispersible tablets.
Main Advantages
- Strict impurity control: The purity of raw materials and key intermediates can reach over 99.0%, with single impurities controlled below 0.1%.
- Mature process: high reaction yield, good quality consistency between batches, suitable for large-scale commercial production.
- Long acting pharmacological mechanism: The corresponding Macitentan product has a unique sustained receptor occupancy characteristic, providing clear clinical differentiation advantages for the formulation.
Contact us sales1@faithfulbio.com or Whats App：+86 17782784795
Why choose us
As a high-end cardiovascular active pharmaceutical ingredient, any inter batch fluctuations of Macitentan API may affect the quality and safety of the final product. Therefore, we monitor from the source and select key intermediates from cooperative factories with well-established quality systems. COA is provided with each batch of goods. With deep integration of the upstream and downstream industrial chains, we have stronger supply resilience and cost optimization capabilities, reasonable prices, sufficient inventory, and can effectively respond to market price fluctuations.
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FAQ
Q1:What are the precautions when storing Macitentan API?
A1:Store at room temperature, away from light, sealed and dry.
Q2:What are the possible adverse reactions of Macitentan?
A2:Anemia (decreased hemoglobin), hepatotoxicity (elevated transaminase), and embryo fetal toxicity (contraindicated during pregnancy).
Q3:What is the mechanism of action of Macitentan?
A3:After CYP3A4 metabolism, the active metabolite ACT-132577 is formed, both of which inhibit the biological activity of ET-1 binding to ETA and ETB. Further prevent ET-1 induced intracellular calcium increase and vascular constriction.
Contact US
We have Macitentan API in stock,contact us sales1@faithfulbio.com or Whats App：+86 17782784795 any time .
