Nimodipine API powder
CAS.NO:66085-59-4
structural formula:C21H26N2O7
EINECS.no:266-127-0
Other names:Nimodipime;Nimodipine
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Nimodipine API powder Manufacturer & Supplier
Nimodipine API powder is the latest generation of 1,4-dihydropyridine calcium channel antagonists, also known as calcium ion blockers. It can inhibit the influx of extracellular calcium ions into vascular smooth muscle cells, and has a protective effect on isolated or in vivo cerebral arteries or ischemic cerebral arteries. It can significantly improve cerebral blood flow and effectively prevent and treat cerebral tissue ischemic damage caused by cerebral vasospasm due to subarachnoid hemorrhage, as well as migraines, sudden deafness, and can also be used for mild to moderate hypertension. Compared to other similar products, the Nimodipine raw powder provided by Xi'an Faithful BioTech Co., Ltd company can effectively regulate calcium in the body, maintain normal physiological functions, and have a particularly prominent effect on cerebral blood vessels. It can also bind to specific receptors in the central nervous system. Selective dilation of cerebral blood vessels can be achieved at appropriate doses, with almost no impact on peripheral blood vessels. Increasing the dose also has good therapeutic effects on hypertension.
Nimodipine API powder Introduction
Nimodipine belongs to calcium channel blockers, and the use of calcium channel blockers to treat hypertension has been widely recognized by medical staff in clinical practice. Clinical applications have shown that Nimodipine API powder can effectively prevent Ca2+from entering cells, inhibit smooth muscle contraction, and relieve vascular spasm. In addition, it is lipophilic and easily passes through the blood-brain barrier. It has a strong effect on cerebral arteries and can effectively prevent or reverse cerebral tissue ischemic damage caused by cerebral vasospasm caused by subarachnoid hemorrhage. It has a relatively small effect on peripheral blood vessels and has a protective effect on ischemic brain injury. In addition, it has the function of protecting and promoting memory, as well as facilitating intellectual recovery. It can selectively act on the smooth muscle of cerebral blood vessels, and there is ample evidence to suggest that it can dilate cerebral blood vessels and simultaneously increase coronary blood flow and lower blood pressure at an increased dose, but it does not reduce cerebral blood flow while lowering blood pressure.
Specifications
Item | Specifications | Results |
Appearance | White to light yellow free flowing powder | Conform |
Odor | Odorless | Conform |
Bulk density | ≥0.20g/ml series product | 0.23g/ml |
Particle size (U.S.mesh) | ≥98% through 80 mesh | Conform |
Appearance of solution | Clear-colorless to light yellow | Conform |
Solubility | ≥99.0% | 99.5% |
Water | ≤5.0% | 3.57% |
Ash | ≤1.0% | 0.43% |
Heavy Metals | ≤10ppm | Conform |
Arsenic | ≤0.5ppm | Conform |
Total Aerobic | ≤1000cfu/g | <1000cfu/g |
E-coli | Negative | Negative |
Salmonella | Negative | Negative |
| purity | ≥ 98.8% | 99.36% |
| Conclusion | Conform with enterprise specification （USP 41）. |
Why Choose Us?
Our Nimodipine API powder has three core advantages:
Quality advantage: The product has passed international authoritative certifications such as FDA and EDQM, and meets international pharmacopoeia standards such as CP, USP, BP, and EP. The purity is ≥ 98.5%, and the impurity content is strictly controlled within 1.0%. All quality indicators are superior to industry standards.
Technical advantages: Advanced Hantzsch synthesis method and liquid chromatography separation and purification process are adopted to ensure stable and reliable product quality. We have large-scale production capacity and can continuously provide high-quality raw materials.
Service advantages: The product price is competitive in the market, providing comprehensive technical support services and stable supply guarantee. Customized solutions can be provided according to customer needs to meet the production needs of different formulations.
please leave a message via email: sales8@faithfulbio.com ,Welcome to the store for inquiries.
Adverse reaction
About 11.2% of patients with subarachnoid hemorrhage experience adverse reactions when using it. The most common symptoms include decreased blood pressure (the degree of decrease depends on the dosage of the medication), hepatitis, skin irritation, gastrointestinal bleeding, thrombocytopenia, occasional transient dizziness, headache, facial flushing, vomiting, gastrointestinal discomfort, etc. In addition, after using Nimodipine API powder in mice, some populations may experience an increase in alkaline phosphatase (ALP), lactate dehydrogenase (LDH), blood glucose, and a very small number of platelet counts.
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FAQ
Q1: What are its quality standards?
The quality standards for Nimodipine API powder require a content of ≥ 98.5%, related substances ≤ 1.0%, drying loss ≤ 0.5%, ignition residue ≤ 0.1%, and heavy metals ≤ 10ppm. The product appearance is a light yellow crystalline powder, odorless, and unstable when exposed to light. Must comply with international pharmacopoeial standards such as CP, USP, EP, etc.
Q2: What is its production process?
Nimodipine was prepared by Hantzsch synthesis method using m-nitrobenzaldehyde, methyl acetoacetate, and methyl 3-aminocrotonate as raw materials, and underwent cyclization reaction in the presence of a catalyst. It is purified and refined by liquid chromatography. The raw materials and preparations are produced in accordance with GMP requirements.
Q3: How to store Nimodipine API powder correctly?
After obtaining it, it should be stored in a cool and dry place with light shielding and sealing. It is recommended to store it at a temperature not exceeding 25 ℃. Avoid moisture, high temperatures, and direct sunlight. We provide Nimodipine raw material powder usually packaged in aluminum foil bags with desiccant inside and cardboard drums outside.
Q4: What is its shelf life?
Under specified storage conditions, the shelf life of active pharmaceutical ingredients is usually 24-36 months. The specific shelf life shall be subject to the product label, and expired products shall not be used.
Contact us
With large-scale production capacity and process optimization, our Nimodipine powder prices are competitive in the market, while providing comprehensive technical support services and stable supply guarantees to ensure that you receive comprehensive support. If you have a procurement plan, please leave a message:sales8@faithfulbio.com.
