Proglumide powder
Synonym: LABOTEST-BB LT00772215;N(2)-benzoyl-N,N-dipropyl-alpha-glutamine;4-(BenzoylaMino)-5-(dipropylaMino)-5-oxo-pentanoic Acid;ProM
CAS NO.: 6620-60-6
EINECS NO.: 229-567-4
Molecular Formula: C18H26N2O4
Purity & Grade: 99%; Medicine grade
Character: White Powder
Free sample: Available
Stock: In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Proglumide powder Manufacturer & Supplier
Xi'an Faithful BioTech Co., Ltd. sells high-quality Proglumide powder. Before shipment, we provide a detailed product analysis report (CoA) to ensure product quality meets specifications, with purity typically reaching 98% or even 99%. Leveraging our extensive experience, we offer detailed technical support and advice to assist clients in their scientific research. We respond quickly to customer inquiries, feedback, and other requests; our experienced staff ensures prompt handling. We have a well-established logistics network to ensure the safe and reliable delivery of products (usually transported in powder form at room temperature or in solvent form at low temperatures) to customers worldwide.
Proglumide powder Introduction
Proglumide powder was the first discovered gastrin antagonist, and both it and benzotript are derivatives of glutaramic acid. Its molecular structure is similar to the terminal structures of two intestinal kinins, gastrin (G-17) and cholecystokinin (CCK). Therefore, its functional amide group specifically competes with G-17 for G-17 receptors on parietal cells, significantly inhibiting G-17-induced secretion of gastric acid and pepsin, increasing the content of aminohexoses in the gastric mucosa, promoting glycoprotein synthesis, and protecting the gastric mucosa, thereby improving the symptoms of peptic ulcers and promoting ulcer healing. This product has little inhibitory effect on gastric acid secretion induced by histamine and vagus nerve stimulation. It does not cause a rebound phenomenon in gastric acid secretion when treating peptic ulcers and gastritis, and gastric acid secretion can remain at normal levels for up to six months after discontinuation of treatment. Because its inhibitory effect on gastric acid secretion is weaker than that of H2 receptor antagonists, it is no longer used alone in the clinical treatment of peptic ulcers, but its choleretic effect has recently received more attention.
COA
| Test items | Specifications | Results | |
| Appearance | White fine powder | Complies | |
| Odor &Tasted | Characteristic | Complies | |
| Proglumide Assay(%) | ≥98.0 HPLC | 99.23 | |
| Loss on Drying(%) | ≤0.5 | 0.11 | |
| Ash(%) | ≤0.5 | 0.21 | |
| Residue on Ignition(%) | ≤0.5 | 0.14 | |
| Moisture Content(%) | ≤0.2 | 0.15 | |
| Particle size(%) | 100%through 80 mesh sieves | Complies | |
| Heavy Metals | |||
| Heavy Metal(ppm) | ≤10.0 | Complies | |
| Pb(ppm) | ≤1.0 | Complies | |
| As(ppm) | ≤1.0 | Complies | |
| Hg(ppm) | ≤0.1 | Complies | |
| Cd(ppm) | ≤1.0 | Complies | |
| Microbiological Tests | |||
| Tota Plate Count(cfu/g) | ≤1000 | Complies | |
| Yeasts and Moulds(cfu/g) | ≤100 | Complies | |
| E.coli(cfu/g) | Negative | Complies | |
| Salmonella | Negative | Complies | |
| Conclusion | Conform with enterprise specification | ||
Why Choose Us?
High Product Quality and Purity: Our proglumide powder is guaranteed to be of high purity, meeting stringent quality standards to ensure its effectiveness and safety in research and development and production.
Strict Quality Control: We implement a comprehensive quality management system. Each batch of product undergoes rigorous testing and analysis, and relevant Certificates of Analysis (COA) are provided for customer peace of mind.
Reliable Supply Chain: We provide a stable and reliable supply to ensure timely fulfillment of customer needs and avoid production interruptions.
Professional Technical Support: We have a professional technical team that can provide necessary product information, application guidance, and answers to questions to help customers use the product more effectively.
Competitive Pricing: While ensuring quality, we offer competitive pricing to help customers control costs.
Excellent Customer Service: We are committed to providing excellent customer service, responding promptly to customer inquiries, processing orders, and resolving after-sales issues to ensure customer satisfaction.
Application Areas
Peptic Ulcers: Proglumide was initially developed and is primarily used to treat gastric and duodenal ulcers. It works by inhibiting gastric acid secretion and reducing gastrointestinal motility.
Gastric Mucosal Protection: It helps protect the gastric mucosa and promotes ulcer healing.
Anti-tumor Potential: New research suggests that proglumide may possess anti-cancer properties. It can inhibit tumor growth and metastasis by increasing T-cell infiltration through altering the tumor microenvironment, such as reducing fibrosis.
Neuroscience: Proglumide is a selective CCK antagonist and is often used as an experimental tool to study the role of CCK as a neurotransmitter or neuromodulator in the central nervous system.
Quality Control:
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FAQ
Q1: What is the target receptor of Proglumide powder?
A1: Proglumide is a cholecystokinin receptor (CCKR) antagonist which non-selectively binds to both the cholecystokinin receptors (CCK1R and CCK2R).
Q2: How does Proglumide powder differ from other anti-ulcer products?
A2: Compared to H2 receptor antagonists, proglumide has a weaker inhibitory effect on gastric acid secretion, but it does not cause a rebound increase in gastric acid and has a low recurrence rate, making it particularly suitable for long-term treatment and prevention of recurrence.
Q3: What are the common side effects of Proglumide powder?
A3: Common side effects are usually mild and transient gastrointestinal discomfort, including nausea, vomiting, abdominal pain, constipation and diarrhea, headache, and dizziness.
Contact Us
Stable supply! Limited-time offer on compliant Proglumide powder! USP/EP/CP certified, purity ≥99%, each batch comes with a complete COA report, ensuring compliance. Please contact my email sales9@faithfulbio.com.
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