Quinidine Powder
CAS.NO:56-54-2
structural formula:C20H24N2O2
EINECS.no:200-279-0
Other names:CONCHININE;CONQUININE;B-QUININE;QUINIDINE;(+)-QUINDINE;QUINDINE;Quinidine
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Quinidine Powder Manufacturer & Supplier
Quinidine Powder is an alkaloid extracted from the bark of Rubiaceae plant, which has a direct effect on cell membrane, mainly inhibiting the transmembrane movement of sodium ions, directly inhibiting the self-discipline, conductivity, stress and contraction of the heart, and also has an anticholinergic effect on the heart. Quinidine API provided by Xi'an Faithful BioTech Co., Ltd is suitable for cardioversion and prevention of atrial fibrillation, atrial flutter, supraventricular and ventricular tachycardia, and treatment and prevention of malignant premature beats.
Quinidine Powder Introduction
Quinidine Powder is an I a-class sodium channel blocker, which can block the influx of Na+ at a low concentration (1μ mol/L), so it can obviously inhibit the excitability and conductivity of ectopic pacing and depolarization tissue, slow down the conduction speed between hearts, prolong the effective refractory period, reduce the excitability of the heart, and prolong the refractory period of atrium more obviously than that of ventricle, thus increasing the conduction frequency of atrium and ventricle.In clinical use, it is well absorbed, almost all of it can be absorbed by gastrointestinal tract, and the peak plasma concentration can be reached after about 2 hours. The bioavailability is 72% ~ 87%. About 80% ~ 90% of Pharmaceutical raw materialss in plasma can be combined with protein, especially in myocardium, which can reach 10 times of plasma concentration. T1/2 is 5~7 hours. After liver metabolism, 20% is excreted with urine in its original form.
Specifications
Item | Specifications | Results |
Appearance | White to yellowish-white,fine powder | Conform |
Solubility | Meets the requirements | Conform |
Identification | A.IR:sample comparing with the spectrum obtained with standard | Conform |
| B.Absorbance:3%value of the standard | 1.0% |
| C.Color reaction:Positive | Posotive |
Specific rotation | -25°~-28 | -26.5° |
Acidity(0.10N NaOH) | 0.50ml/g max | 0.04% |
Heavy metals | 0.1%max | 0.04% |
3-0-Methylmethyldopa | 0.5% | Less than 0.5% |
Residual solvents | Meets the requirements | Meets the requirements |
Assay | 98.0-101.0% | 99.6% |
| Conclusion | Conform with enterprise specification （USP 41）. |
Why Choose Us?
1. Quality advantage: With advanced production technology, the products have passed the international authoritative certifications such as FDA and EDQM, and meet the regulatory requirements of major global markets. We have a perfect quality control system to ensure that every link from raw material procurement to finished product delivery meets the requirements of good manufacturing practice (GMP).
2. Technical advantages: Solid-phase high-efficiency synthesis technology was developed by using solid-phase polypeptide synthesis technology and Fmoc solid-phase synthesis principle, and the yield of quinidine API was as high as 85% and the yield of pure product was 60% by using microwave reaction technology. In the process of synthesis, TBTU/HOBT/DIA system is used as condensation reagent to ensure the purity of the product to reach over 99.5%.
3. Supply advantage: With large-scale production capacity and process optimization, our products are competitive in the market. We can provide customized solutions according to customers' needs, meet the needs of different preparations, and provide perfect technical support services and stable supply guarantee.
4. Packaging specifications: 1kg, 5kg, 10kg, 25kg and other packaging specifications can be provided, and packaging can be customized according to customer needs. The product should be kept in a dark and airtight place. It is suggested that the storage temperature should be 2-8℃ and the shelf life should be 24 months.
By choosing our quinidine bulk API powder, you will get high-quality products, competitive prices, stable supply and all-round technical support, which will provide a solid guarantee for your preparation production.Our email address is:sales8@faithfulbio.com, Welcome your letter.
Side effects:
Mild: abdominal pain, bitter taste, unconsciousness, spasm, diarrhea, flushing, headache, loss of appetite, nausea, fidgeting and vomiting. After adjusting the dosage, these side effects may disappear as the body adapts to the Pharmaceutical raw materials.
Serious: Tell your doctor about any persistent or particularly disturbing side effects, especially blurred vision, dyspnea, dizziness, weakness, fever, headache, golden rhinoceros, palpitation, impatience, tinnitus, pharyngitis, abnormal bleeding or blue skin.
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FAQ
Q1: What are the quality standards for Quinidine API powder?
Our Quinidine powder has a purity of ≥ 98.5%, with impurity content strictly controlled within 1.0%, single impurity less than 0.5%, biological activity ≥ 80.0%, endotoxin ≤ 50EU/mg, and all quality indicators comply with international pharmacopoeia standards such as CP, USP, BP, and EP.
Q2: What international certifications has Quinidine powder passed?
Our Quinidine API powder has been certified by international authorities such as FDA and EDQM, and meets regulatory requirements in major global markets. We have a comprehensive quality control system to ensure that every step from raw material procurement to finished product delivery complies with Good Manufacturing Practice (GMP) requirements.
Q3: What is its production process?
We adopted solid-phase peptide synthesis technology and developed an efficient solid-phase synthesis process based on the Fmoc solid-phase synthesis principle. Using microwave reaction technology, the yield of Quinidine crude product reached 85%, and the yield of pure product reached 60%. During the synthesis process, the TBTU/HOBt/DIEA system was used as the condensing reagent. At peptide positions where alpha helices and beta angles are easily formed, the coupling reaction was fully promoted through HOBt/DIC supplementation, ensuring product purity of over 99.5%.
Q4: What are our packaging specifications?
We offer various packaging specifications such as 1kg, 5kg, 10kg, 25kg, etc., and can customize packaging according to customer needs. The product should be stored in a light shielded and sealed environment, with a recommended storage temperature of 2-8 ℃ and a shelf life of 24 months.
Contact us
Quinidine powder provided by us is a pharmaceutical-grade raw material medicine, with purity ≥98.5%, impurity content strictly controlled within 1.0%, single impurity less than 0.5%, biological activity ≥80.0%, endotoxin ≤50EU/mg, and all quality indexes meet the international pharmacopoeia standards such as CP, USP, BP and EP. A complete certificate of analysis (COA) is provided for each batch of products. If you are interested, please leave a message::sales8@faithfulbio.com.
