Raltegravir potassium API
CAS.NO:871038-72-1
structural formula:C20H20FN6O5.K
EINECS.no:682-461-3
Other names:Raltegravir potassium;Raltegravir Potassium Salt;MK 0518;CS-1950;CS-1293;Isentress potassium salt;ISENTRESS POTASSIUM SALT;MK0518 POTASSIUM SALT;MK-0518 POTASSIUM SALT;MK 0518 POTASSIUM SALT;MK 0518 potassium salt
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Raltegravir potassium API Manufacturer & Supplier
Raltegravir potassium API is the main active ingredient of raltegravir., also known as MK-0518. According to relevant records, Raltegravir potassium Salt raw powder provided by Xi'an Faithful BioTech Co., Ltd can work by blocking an enzyme necessary for HIV virus replication. He was approved and listed by the US FDA in 2007, and was approved and listed in Europe the next year. Clinicians unanimously praised its effect, and all believed that MK-0518 potassium salt was the first integrase inhibitor in AIDS antiviral drugs.
Raltegravir potassium API powder Introduction
The Raltegravir potassium API can be combined with other antiretroviral drugs to treat human immunodeficiency virus (HIV-1) infection. Its mechanism of action is to slow down the occurrence of HIV-1 infection by inhibiting the HIV integrase required for viral replication. Using an electron microscope, it can be observed that when Raltegravir is combined with other anti HIV drugs, it can reduce the amount of HIV in the blood and increase the number of white blood cells called CD4+T cells, which helps to combat other infections. Studies on interactions with Ritonavir, Efavirenz, Tipranavir, Tenofovir, and others have shown that there is no cross resistance phenomenon in drug resistance, and it has synergistic effects with multiple pharmaceutical raw materials.
Specifications
Item | Specifications | Results |
Appearance | White to light beige solid powder | Conform |
Odor | No abnormal odor | Conform |
Boiling point | > 155 °C | 158 °C |
Relative density | 0.96 | Conform |
Heavy Metal | ≤ 10 ppm | Negative |
Total Plate Count | ≤ 1000 cfu/g | 1.23 cfu/g |
Yeast&Mold | ≤ 100 cfu/g | 0.48 cfu/g |
E.coil | Negative | Negative |
Salmonella | Negative | Negative |
Assay | ≥ 98.88% | 99.85% |
| Conclusion： | Conform with enterprise specification （USP 41）. |
Why Choose Us?
MK-0518 potassium salt is a landmark drug in the field of AIDS treatment, and is famous for its powerful, rapid inhibition of the virus and good tolerance. As the pioneer of integrase inhibitors, it remains a core component of many highly effective antiretroviral therapy regimens to this day. If you want to develop a larger market in this field, you cannot bypass its research. Our company not only has production capacity, but our storage conditions are also very strict. After leaving the factory, the Raltegravir Potassium Salt API powder is frozen and stored at -20 ° C. In theory, after stable storage for 4 years, the purity usually reaches over 98%, and the microorganisms also meet pharmacopoeial standards, which can ensure your future research and project expansion. Therefore, when choosing a company, we are the best choice. If you are interested, please contact me via email:sales8@faithfulbio.com.
Bioactivity
Raltegravir (MK-0518) is an effective integrase (IN) inhibitor that acts on WT and S217QPFVIN, with IC50 values of 90nM and 40nM in cell-free assays, respectively. Its selectivity for HIV-1 IN is over 1000 times higher than other related Mg2+- dependent enzymes, such as HCV polymerase, HIV reverse transcriptase HIVRNaseH、 Human alpha, beta, gamma polymerases.In addition, the Raltegravir potassium API is mainly eliminated through the glucuronidation pathway mediated by UGT1A1. However, it should be noted that our study found that when it was combined with UGT1A1 strong inducer (such as Rifampicin), the plasma concentration would decrease; When combined with UGT1A1 strong inhibitor (such as Atazanavir), the plasma concentration will increase. Therefore, it is very necessary to detect the abnormal fluctuation of data in personalized use.
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FAQ
Q1: What are your accepted payment methods? We offer a range of secure and convenient payment options to facilitate smooth transactions, including T/T (Bank Transfer), Western Union, MoneyGram, WeChat Pay, Alipay, and Credit Card payments.
Q3: When will my order be shipped after payment confirmation? For in-stock items, orders are typically shipped within 1–3 business days after payment is confirmed. Should your order involve customization or require special handling, we will provide a clear timeline upfront to keep you informed.
Contact us
We are committed to making every patient in need have access to high-quality innovative drugs without burden, and contributing our strength to the public health goal of "ending the AIDS epidemic". For this purpose, we provide high purity, strictly compliant with international pharmacopoeia standards, and with complete quality documentation (COA) for the potassium salt of Raltegravir, ensuring that your research or production obtains reliable, consistent, and traceable pharmaceutical raw materials. If you have any new plans, please leave a message:sales8@faithfulbio.com
