Ropivacaine HCL API powder
CAS.NO:132112-35-7
structural formula:C17H26N2O.ClH.H2O
EINECS.no:663-286-1
Other names:(S)-Ropivaxaine hydrochloride;LEA-103;(S)-ropivacaine hydrochloride hydrate;Ropivacaine Hydrochloride (200 mg);Ropivacaine HCl
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Ropivacaine HCL API powder Manufacturer & Supplier
Ropivacaine HCL API powder is a long-acting amide based local anesthetic. It achieves local anesthesia and analgesia by reversibly blocking sodium ion channels on the membrane of nerve cells, thereby inhibiting the generation and transmission of nerve impulses. The (S)-ropivacaine hydrochloride hydrate provided by Xi'an Faithful BioTech Co., Ltd company is known for its unique "sensory motor nerve separation block" effect. This means that it can effectively block sensory nerves (eliminate pain) at lower concentrations, while having a weaker blocking effect on motor nerves (preserve muscle movement function), making it significantly superior to other anesthesia and analgesic pharmaceutical materials in the market.
Ropivacaine HCL API powder Introduction
Ropivacaine HCL API powder can reduce the permeability of sodium ions on the nerve cell membrane, thereby reversibly blocking the transmission of nerve impulses. Its molecular weight and protein binding rate are similar to Bupivacaine raw powder, but the difference in lipid solubility between the two is significant at 2.9 and 10. Due to its low lipid solubility, the pKa values of proteins and amino acid side chains are crucial for enzyme activity and protein stability in biochemistry. ）Relatively high, indicating that its penetration speed through the sheath is relatively slow. However, it should be noted that it has the phenomenon of constricting spinal cord blood vessels. As its concentration and dosage increase, there may be constriction of the pia mater blood vessels and spinal cord ischemia injury. Therefore, under the premise of meeting surgical requirements, it is advisable to choose the lowest effective concentration and dosage of local anesthetics as much as possible.
Specifications
Item | Specifications | Results |
Appearance | White fine powder | Conforms |
Identification (IR) | Concordant with reference spectrum | Conforms |
Assay | ≥98% | 98.42% |
bulk density | 35-55g/100ml | 48g/100ml |
Heavy Metals | ≤10ppm （GB/t 5009.74） | 5ppm Conforms |
Loss on Drying | ≤1.0% | 0.25% |
Residue on Ignition | ≤0.3% | 0.08% |
Chromatographic purity | Meets the requirements | Conforms |
Organic volatile impurities | Meets the requirements | Conforms |
Microbial assessment | Compliance with indicators | Conforms |
BSE | not detected | not detected |
GMO | not detected | not detected |
Allergen | not detected | not detected |
Radiation | not detected | not detected |
Pesticides Residue | Meet USP Requirements | Conforms |
| Conclusion | Conform with enterprise specification （USP 41）. |
Why Choose Us?
When you need Ropivacaine HCL API powder for relevant research, I believe you are very concerned about the characteristics and market demand of ropivacaine hydrochloride API. However, our company can provide it as a high-value pharmaceutical raw material with clear clinical advantages (high safety, sensory-motor separation), meeting high-standard quality requirements, and possibly having unique and stable technology. At present, it has met the needs of most pharmaceutical enterprises for the production of related anesthetic and analgesic preparations. If you have a purchase plan, please leave a message by email:sales8@faithfulbio.com.
Medical risks:
According to a large number of clinical research data, it is similar to other local anesthetics, and its safety problems are mostly related to dosage or technology. The common risks at present are as follows:
1.Nervous system: hypotension, dizziness, nausea, paresthesia, chills. In severe cases, systemic toxic reactions may occur, such as tinnitus, numbness of lips, confusion, muscle tremor, and even convulsions and coma. 2.Heart system: heart rate slows down and blood pressure drops. Severe poisoning can lead to arrhythmia and cardiac arrest (but the incidence is lower than bupivacaine). 3.Others: allergic reaction (rare), urinary retention, pain at puncture site, etc.
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FAQ
Q1: Will it have long-term effects on memory or the brain?
There is currently no evidence to suggest that therapeutic doses of ropivacaine have long-term effects on brain function or memory. And according to observation, it will be rapidly metabolized by the body. The short-term 'brain confusion' that occurs after surgery is more related to surgical stress, disrupted sleep rhythms, and other adjuvant medications.
Q2: If I am allergic to Procaine, can I still use ropivacaine?
Usually, it is possible, but more cautious preventive measures need to be taken.. Procaine belongs to the "ester" class of local anesthetics, while ropivacaine belongs to the "amide class". The chemical structures of the two are different, and the possibility of cross allergy is extremely low.
Q3: Does ropivacaine contain "hormones" or "painkillers"?
Not included. Ropivacaine itself is a pure local anesthetic, not a hormone, nor a systemic analgesic. However, in clinical analgesic regimens, doctors sometimes combine it with other pharmaceutical ingredients to enhance analgesic effects, reduce individual dosages and side effects.
Contact us
Ropivacaine HCL API powder is a very important pharmaceutical ingredient in modern anesthesia and pain treatment. The characteristic of "sensory motor separation" is currently a research focus in medicine. If you happen to be working on this topic, please contact us. My email is:sales8@faithfulbio.com
