Tebipenem Pivoxil API

Xi'an Faithful BioTech Co., Ltd: Your Trusted Tebipenem Pivoxil API Pure Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd is a professional enterprise specializing in high-end antibiotic raw material and intermediate supply chain services. We have been deeply involved in the field of penem antibiotics for 10 years, and our main product, Tebipenem Pivoxil API, has a stable inventory. We can achieve fast delivery within 3 working days after order confirmation, and have provided raw material support to more than 20 domestic and foreign formulation production enterprises and research and development institutions.

Tebipenem Pivoxil API Introduction

Tebipenem Pivoxil is the world's first prodrug of oral carbapenem antibiotics. After oral administration, it rapidly hydrolyzes into the active ingredient Tabipenan under the action of esterases in the body, exerting a potent bactericidal effect by inhibiting bacterial cell wall synthesis. Tebipenem Pivoxil API has a molecular weight of 497.63 and appears as a white to off white powder. It fills the gap of carbapenems that can only be administered by injection and is known as an "oral injection grade antibiotic".

Specifications

Application area of Tebipenem Pivoxil API

• Pediatric respiratory infections: mainly used to treat pneumonia, otitis media, and sinusitis in children who are resistant to traditional antibiotics, and is currently an important choice for oral treatment of severe infections in children.
• Complex urinary tract infection (cUTI): including acute pyelonephritis, especially infections caused by Escherichia coli producing ESBL (extended spectrum beta lactase).
• Community acquired pneumonia (CAP): suitable for mild to moderate infections caused by Streptococcus pneumoniae (including penicillin resistant strains) and Haemophilus influenzae.
• Sequential treatment: After the patient's condition stabilizes, replace injectable carbapenems (such as Meropenem) to achieve a transition from intravenous to oral administration and shorten hospitalization time.

Main Advantages

• High purity standard: The purity of the raw powder can reach NLT 98% or even above 99.0%, with single impurities controlled below 0.1%, far higher than ordinary pharmaceutical grade, ensuring the dissolution and bioavailability of the formulation production.
• Excellent oral bioavailability: As a prodrug, Tebipenem Pivoxil API has high lipid solubility and is quickly converted into active ingredients after intestinal absorption. In animal experiments, the highest bioavailability can reach 71.4%, and it has a rapid bactericidal effect.
• Wide antibacterial spectrum: It exhibits strong antibacterial activity against both Gram positive bacteria (such as drug-resistant Streptococcus pneumoniae) and Gram negative bacteria (such as Haemophilus influenzae), and its antibacterial effect is superior to traditional cephalosporins.
• Good stability: Under recommended storage conditions (20 ° C), the chemical properties of the raw powder are stable, with a shelf life of up to 2 years, making it easy for long-term storage and cross-border transportation.

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Why choose us

1. Compliance and Qualification Hard Power: We supply raw material intermediates produced in accordance with GMP standards, and our cooperative production line has passed ISO quality system certification.
2. Significant delivery efficiency: Leveraging the advantages of the raw material pharmaceutical industry belt, we have a standardized spot inventory system. Samples will be sent out within 1 working day, and bulk orders will be shipped within 3 working days, which is 40% shorter than the industry average delivery cycle. Urgent orders will no longer be your production bottleneck.
3. Flexible cooperation mode: Whether you are a research institution that requires samples of up to 100 grams, or a production institution that requires raw materials of up to kilograms, we have corresponding packaging solutions (aluminum foil bags, cardboard drums, or customized) and pricing systems to support long-term strategic price locking and help you hedge the risks of raw material market fluctuations.

Quality Control

R&D Results

Packaging and Transportation

After-Sales Service

Qualification Certification

Exhibition

FAQ

Q1:What is the difference between Tebipenem Pivoxil and Tebipenem?

A1:Tebipenem Pivoxil is the prodrug of Tebipenem (Prodrug). Tebipenem itself has poor oral absorption, while Tebipenem Pivoxil greatly improves its lipid solubility and intestinal permeability by introducing a "pilvoate" group on the carboxyl group, allowing it to be effectively absorbed into the bloodstream and hydrolyzed to release Tebipenem with bactericidal activity.

Q2:Is Tebipenem Pivoxil safe for patients allergic to Penicillin G?

A2:Although carbapenems and Penicillin G are both beta lactam antibiotics, there is a certain risk of cross allergy (about 1%). Patients with a history of severe allergy to Penicillin G (such as anaphylactic shock) are usually contraindicated. However, in clinical practice, for patients with mild allergies who require medication, strict desensitization treatment or medical monitoring is necessary. We suggest that customers confirm the medication warning labels for the target market before purchasing.

Q3:What are the main impurity control difficulties of Tebipenem Pivoxil?

A3:The main difficulty lies in the control of enantiomers and ring opening degradation products. Due to the presence of multiple chiral centers in the molecular structure, isomeric impurities are prone to occur during synthesis and storage. Our process uses low-temperature crystallization technology to strictly control the content of isomers (single impurities<0.1%), and uses aluminum foil vacuum packaging to isolate moisture and prevent hydrolysis and ring opening of the main components.

Contact US

We will be glad to receive your inquiry sales1@faithfulbio.com.With high-purity quality Tebipenem Pivoxil API, we help you seize the opportunity in the oral antibiotic market.