Vorinostat 99%
CAS NO.:149647-78-9
Molecular formula:C14H20N2O3
EINECS:682-505-1
Synonyms:CS-1949;SAHA cpd;UNII-58IFB293JI
Purity : 98% HPLC
Certificate:COA; HPLC; MSDS; TDS,etc.
MOQ : 100g
Shipping: DHL/FedEx/UPS/USPS Safe and fast delivery
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Vorinostat 99% Manufacturer & Supplier
Xi'an Faithful BioTech Co., Ltd has been deeply involved in the field of small molecule APIs for many years, committed to providing one-stop services from research and development to commercial production for global pharmaceutical companies. Vorinostat 99% is one of our reputation products, winning customer recognition and praise with excellent quality.
Vorinostat 99% Introduction
Vorinostat 99% (CAS: 149647-78-9) is the world's first approved histone deacetylase (HDAC) inhibitor, launched in 2006. It can inhibit HDAC activity, induce tumor cell cycle arrest and apoptosis, and has minimal impact on normal cells. As a new type of molecular targeted drug, high-purity raw powder is the core raw material for preparing oral formulations.
Specifications
| Item | Specification | Result |
Appearance | White to orange crystalline powder | Complies |
| Identification | Positive | Positive |
| Impurity A | ≤0.15% | 0.1% |
| Individual Impurity | ≤0.1% | 0.085% |
Total impurities | ≤0.5% | 0.18% |
Heavy metals | ≤10ppm | <10ppm |
| Loss on drying | ≤1.0% | 0.45% |
| Residue on ignition | ≤0.1% | 0.05% |
Assay | ≥98.5% | 99.4% |
Conclusion | Complies with In-house standard | |
Application area
The applications mainly focus on:
- Skin T-cell lymphoma (CTCL): Used to treat CTCL patients who have experienced disease progression, recurrence, or drug resistance after two previous systemic treatments.
- Combination therapy: Clinical trials have shown that when used in combination with radiopharmaceuticals and immune antibodies, the disease control rate can reach 75% in recurrent/refractory neuroblastoma.
- Rare Disease Research: Clinical trials are currently underway to explore the role of Vorinostat 99% in epigenetic regulation of rare genetic neurological diseases such as Rett syndrome and Pitt Hopkins syndrome.
Main Advantages of Vorinostat 99%
- High purity: Our Vorinostat has a purity of over 99%, with single impurities less than 0.1% and clear impurity spectra, fully meeting the stringent requirements of formulation research and production.
- Mature synthesis process: adopting an improved synthesis route, with sodium hydroxide pretreatment and alkaline environment control, resulting in high product yield.
Contact us sales1@faithfulbio.com or Whats App：+86 17782784795
Why choose us
- Vorinostat 99% uses validated and mature synthetic processes, with small differences between batches and stable quality. COA can be provided with each batch to ensure your production from the source.
- Flexible supply, no high minimum order line, sample orders are also supported.
- Transportation safety is guaranteed. We have been specializing in API foreign trade for many years and have stable transportation channels, which is also one of our advantages. The package packaging is tight and the transportation is safe and effective. Choosing us means choosing a strategic partner to grow together with you.
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FAQ
Q1:Is Vorinostat only applicable to cutaneous lymphoma?
A1:The currently approved core indication is cutaneous T-cell lymphoma, but it has also shown positive potential in clinical trials targeting neuroblastoma, lung cancer, and certain rare genetic diseases.
Q2:What is the biological activity of Vorinostat?
A2:Vorinostat has an IC50 of~10nM in cell-free assays. Vorinostat inhibits efficient HPV-18 DNA amplification.
Q3:What is the water solubility of Vorinostat?
A3:Almost insoluble in water, soluble in DMSO.
Contact US
Are you interested in Vorinostat 99% ？Contact us sales1@faithfulbio.com or Whats App：+86 17782784795 any time .
