99% J-147 Powder
Synonym: J147/J-147;Nootropic J147;CS-1446
CAS NO.: 1146963-51-0
EINECS NO.: 1592732-453-0
Molecular Formula: C18H17F3N2O2
Purity & Grade: 99%; Medicine grade
Character: White Powder
Free sample: Available
Stock: In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 5g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted 99% J-147 Powder Manufacturer & Supplier
Xi'an Faithful BioTech Co., Ltd. sells high quality 99% J-147 Powder. Our company has the ability to cover multiple product categories and can simultaneously supply "API powder + excipient powder + compound premixed powder", reducing the number of suppliers for pharmaceutical enterprises (from "multi-supplier decentralized procurement" to "single-supplier integrated procurement"), and lowering supply chain management costs (such as acceptance, logistics, and compliance review costs).
99% J-147 Powder Introduction
99% J-147 Powder is a particularly effective and active neuroprotective agent that can enhance cognitive ability. J-147 can pass through the blood-brain barrier (BBB). J-147 inhibits monoamine oxidase B(MAOB) and dopaminetransporter, with EC50 values of 1.88μM and 0.649μM, respectively. J-147 has the potential for application in the research of Alzheimer's disease (AD). Results from these behavioral assays show that J147 has the ability to rescue the cognitive decline and disinhibition phenotype associated with AD when administered at an extremely late stage in the disease progression when pathology is already far advanced.
COA
| Test items | Specifications | Results |
| Active Ingredients | ||
| Purity(HPLC) | ≥99% | 99.93% |
| Physical Control | ||
| Appearance | White-off white solid | Conforms |
| Color | White | Conforms |
| Odor &Taste | Characteristic | Conforms |
| Identification | H-NMR | Conforms |
| Loss on Drying | ≤1.0% | 0.59% |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | conforms |
| Residue on Ignition | ≤0.5% | 0.02% |
| Chemical Control | ||
| Heavy Metals(As Pb) | NMT20PPM | Conforms |
| Related Substance | Max Single Impurity≤0.3% | 0.03% |
| Conclusion | Conform with enterprise specification | |
Why Choose Us?
We offer fine powder with a purity of ≥98% (up to 99% in some batches), which has been tested through multi-dimensional methods such as high-performance liquid chromatography (HPLC), and the impurity content is lower than the industry standard. The product is packaged in light-proof and moisture-proof materials and can be stably stored at room temperature for more than 12 months.
Regular orders are processed within 1 to 3 working days. Through international express channels such as DHL and FedEx, goods can be delivered to major countries and regions around the world within 7 working days.
The product is packaged in UV-resistant glass bottles or aluminum foil bags and supports various specifications from gram to kilogram levels.
We have established long-term cooperation with most pharmaceutical companies, with an annual production capacity of kilograms, which can meet the large-scale procurement needs of research institutions and enterprise customers. In special circumstances (such as fluctuations in raw materials), we promise to give priority to ensuring the supply to our core customers.
Application Areas
The anti-aging mechanism targeting mitochondria
The product inhibits excessive ATP production by binding to ATP synthase, reducing oxidative stress and neurodegenerative damage. In Alzheimer's disease model mice, J-147 significantly reduced the level of β -amyloid protein, increased brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), and improved synaptic plasticity and cognitive function.
The permeability and safety of the blood-brain barrier
Compared with traditional Curcumin, J-147 can efficiently pass through the blood-brain barrier, and its mechanism of action does not rely on Acetylcholine or Phosphodiesterase I, avoiding the common side effects of neurotransmitter interference. Preclinical studies have shown that it has high selectivity in regulating mitochondrial function and good safety for long-term use.
Potential for cross-domain applications
In addition to Alzheimer's disease research, J-147 has shown potential in fields such as anti-aging, neural regeneration, and improvement of vascular function. For example, it maintains mitochondrial homeostasis by regulating the metabolism of Acetyl coenzyme A sodium salt.
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FAQ
Q1: How was 99% J-147 Powder discovered?
A1: Schubert's group developed J147 in 2011, after screening for compounds from plants with an ability to reverse the cellular and molecular signs of aging in the brain. J147 is a modified version of a molecule (curcumin) found in the curry spice turmeric.
Q2: Are there any side effects of 99% J-147 Powder?
A2: The high bioavailability and blood-brain barrier penetration of J147 may also have contributed to its substantial therapeutic effect. Notably, no significant side-effects of J147 has been reported.
Q3: How does 99% J-147 Powder affect the brain?
A3: J147 treatment ameliorates neuropathological changes and improves functional recovery, possibly by boosting AMPK activity in neurons, inhibiting ER stress-activated UPR signaling, and cleaving SREBP1.
Contact Us
Now decide to order 99% J-147 Powder immediately? Please contact us via email: sales9@faithfulbio.com. Regarding the purchase quantity, shipping details and other requirements, we will reply as soon as possible after receiving the email.
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