CAS NO.: 130929-57-6
Molecular formula:C14H15N3O5
Synonyms:(E)-2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide;ENTACAPONE
Shelf life: 24 months
Purity : 98% HPLC
Certificate:COA; HPLC; MSDS; TDS,etc.
MOQ : 10g; 100g;1kg
Shipping: DHL/FedEx/UPS/USPS Safe and fast delivery
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse" data-aw-url="https://www.faithfulbiochem.com/nootropic-ingredients-powder/entacapone-api-powder/" title="Entacapone API powder">
Xi'an Faithful BioTech Co., Ltd is a high-quality supplier of Entacapone API powder, an anti Parkinson's disease drug. Since 2014, we have been focusing on export trade of raw materials, pharmaceutical intermediates, plant extracts, and other products. Through the unremitting efforts of our team, we have developed a number of factory production bases to control product quality from the source. With these, we have strong competitiveness in the industry and have won recognition from customers around the world.
Entacapone API powder is an anti Parkinson's disease drug that was first marketed in Sweden. It is a highly selective and potent catechol oxymethyltransferase (COMT) inhibitor that rarely penetrates the blood-brain barrier and mainly acts in the intestine. It is an adjuvant drug for drugs such as levodopa. Our Entacapone products have undergone layer by layer testing to meet international standards, with first-class quality. We have improved the production process, reduced production costs, and increased yields to ensure that our products meet the needs of various scenarios.
Item | Specification | Results |
Identification | IR and HPLC spectrum shall conform to the standard sample | Conform |
Appearance | greenish yellow to yellow powder | Conform |
Sulphated Ash | ≤ 0.1% | 0.03% |
Loss on Drying | ≤ 0.5% | 0.24% |
Purity(HPLC) | ≥98.0% | 99.6% |
Sum of Impurity other than A | ≤ 0.2% | 0.11% |
Impurity A | ≤ 0.15% | 0.08% |
Unspecified Impurity | ≤ 0.1% | 0.03% |
Conclusion:Conform with enterprise specification |
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Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, mainly used for the following purposes:
Used in combination with Levodopa to improve motor symptoms such as tremors, stiffness, and bradykinesia in Parkinson's disease patients.
By inhibiting COMT enzyme activity and reducing the metabolism of Levodopa in the body, the duration of its efficacy is prolonged, thereby reducing the frequency and duration of "off phase" (symptom fluctuation phase) attacks.
For patients with a long course of illness and fluctuating symptoms (end of dose phenomenon), Entacapone can be used as a booster for Levodopa to optimize drug efficacy.
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Q1:What is the purpose of entacapone?
A1: Entacapone is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa therapy. Entacapone selectively and reversiblly inhibits catechol-O-methyltransferase (COMT). In mammals, COMT is distributed throughout various organs with the highest activities in the liver and kidney.
Q2:What is a frequent side effect of entacapone?
A2:This medicine may make you dizzy or drowsy. It may even cause you to fall asleep without warning while you drive, talk, or eat
Q3:Does entacapone increase dopamine?
A3: ENTACAPONE treats the symptoms of Parkinson disease in people who are taking Levodopa. It works by increasing the amount of dopamine in your brain, a substance which helps manage body movements and coordination. This reduces the symptoms of Parkinson, such as body stiffness and tremors.
As an adjuvant drug for Parkinson's disease, Entacapone API powder brings good news to Parkinson's patients. Our Entacapone powder has high purity and low impurities, making it the best choice for research or production. Please feel free to contact us via Email: sales12@faithfulbio.com .