Astressin-B peptide
Other names:Astressin-B peptide;Astressin B peptide
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Astressin-B peptide Powder Manufacturer & Supplier
As a selective CRF2 receptor antagonist, Astressin-B peptide has shown broad application prospects in multiple fields such as neuroprotection, anti anxiety, hair growth promotion, and anti-inflammatory. With further research on its mechanism of action and preclinical studies, Astressin-B is expected to become a novel drug candidate for treating various diseases. The Astressin-B Xi'an Faithful BioTech Co., Ltd provide is a cyclic octapeptide belonging to the corticotropin releasing factor (CRF) receptor antagonist family. In addition to the above effects, it also has a unique selective mechanism of action and broad application prospects
Astressin-B peptide Powder Introduction
As a selective CRF2 receptor antagonist, the mechanism of action of Astressin-B peptide powder is mainly based on its specific binding to CRF receptors. Research has shown that Astressin-B has an IC50 value of 1.3 nM for the CRF2 receptor and an IC50 value greater than 500 nM for the CRF1 receptor, demonstrating high selectivity for the CRF2 receptor. This selective antagonistic effect enables it to effectively block the CRF2 receptor-mediated signaling pathway, thereby regulating various physiological processes such as stress response, anxiety state, and neuroprotection.In addition, Astressin-B shows promising application prospects. In a rat model of stress or adrenalectomy, Astressin-B significantly outperformed any previously tested antagonist in reducing hypothalamic adrenocorticotropic hormone (ACTH) secretion.
Specifications
Item | Specifications | Results |
Appearance | White powder | Conforms |
Purity(HPLC) | ≥99.0% | 99.11% |
Single Impurity (HPLC) | ≤2.0% | Conforms |
Peptide Content (N%) | ≥80.0% | 84.5% |
Water Content (Karl Fischer) | ≤8.0% | 6.7% |
Acetate Content (HPIC) | ≤12.0% | 7.8% |
MS (ESI) | Conforms | Conforms |
Mass Balance | 95.0~105.0% | Conforms |
| Conclusion： | Conform with enterprise specification （USP 41）. |
Why Choose Us?
By choosing our Astressin-B peptide powder, you will gain the following core advantages:
1.Excellent purity and quality assurance
Our Astressin-B peptide adopts advanced peptide synthesis technology to ensure stable product purity of over 98%. Through various analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for batch validation, we provide detailed and traceable third-party quality analysis reports for each batch of products to ensure the accuracy and reliability of your research data.
2.Professional technical support and services
We have an experienced technical team that can provide you with professional advice and technical support regarding product storage, dissolution, and use. Our team has a deep understanding of peptide drugs and can provide you with constructive professional support in process development, quality control, and other aspects, becoming an extension of your technology.
3.Stable supply chain and timely delivery
We have the ability to independently control production and can quickly respond to your needs, ensuring timely and accurate delivery of orders to your hands. Whether it's small-scale scientific research trials or large-scale commercial orders, we can be your reliable and stable support.
4.Strict quality management system
We have a comprehensive quality management system that complies with international cGMP (Good Manufacturing Practice) standards. From raw material procurement, production process to finished product packaging, every link has detailed documentation and strict quality monitoring to ensure that every batch of products you receive has complete traceability and consistency.
5.Rich product specification selection
We offer a variety of Astressin-B peptide powder in different packaging sizes, including 1mg, 5mg, 10mg, etc., with a minimum order quantity of milligrams to meet your needs at different stages of research.
6.Wide range of application areas supported
Our Astressin-B peptide has shown promising application prospects in multiple research fields such as neuroprotection, anti anxiety, and hair growth promotion. As a selective CRF2 receptor antagonist, it can effectively block CRF2 receptor-mediated signaling pathways, thereby regulating various physiological processes such as stress response, anxiety state, and neuroprotection.
By choosing us, you will not only receive products, but also a professional partner. We are committed to providing comprehensive services to help you solve practical problems and ensure the smooth progress of your research project. Contact us （email :sales8@faithfulbio.com） immediately for the latest product information and detailed technical support services!
Tapplied research
Main application areas
1. Neuroprotective effect
Astressin-B exhibits significant neuroprotective effects. Research has shown that intraventricular infusion of Astressin-B can reduce hippocampal cell damage 30 minutes before and 10 minutes after epileptic seizures, with a protective effect of up to 84%. Its protective effect is superior to other CRF antagonists.
2. Anti anxiety effect
Astressin-B can significantly reverse anxiety like reactions induced by social stress and intraventricular injection of CRF in the elevated maze, but failed to block CRF induced motor activity effects in familiar environments.
3. Hair growth promotion
Research has found that Astressin-B has practical value in hair and eyelash regeneration. By regulating stress hormone receptors, Astressin-B can promote hair growth, providing new ideas for its application in the field of hair loss treatment.
4. Anti inflammatory activity
Astressin-B peptide also exhibits certain anti-inflammatory activity, which provides a theoretical basis for its application in the treatment of inflammation related diseases.
Quality Control:
R&D Results:
Packaging and Transportation:
After-Sales Service:
Qualification Certification:
Transaction Feedback:
Exhibition:
FAQ
Q1. What is the relationship between Astressin-B and CRH?
CRH is an "agonist" that acts like a key, inserted into a receptor (lock), initiating a stress response.
Astressin-B is an "antagonist" that acts like a cut key that can be inserted into a lock but cannot initiate a response, while also preventing the insertion of a real key (CRH), thereby suppressing stress responses. In summary, they are antagonistic relationships.
Q2. Are Astressin-B and Astressin the same thing?
Not exactly the same, but closely related. They all belong to CRF antagonists, but differ in chemical structure.
It can be understood that Astressin-B is a variant or improved version of Astressin, which may have different binding affinities or pharmacokinetic properties. In non scientific discussions, these two names are sometimes used interchangeably.
Q3. How to better preserve it?
Astressin-B needs to be stored under specific conditions to ensure its stability. In powder state, it can be stored for 2 years at -20 ° C and 1 year at 4 ° C; In solvents, it can be stored for 6 months at -80 ° C and for 1 month at -20 ° C. The product needs to be sealed and stored away from moisture and light.
Q4. How can it be used for hair growth research? How effective is it?
Research has shown that hair follicles themselves are a "micro stress system" that can locally produce CRF. Under pressure, an increase in CRF levels in hair follicles can induce premature transition from the growth phase to the resting phase, leading to hair loss. As a "blocker" of CRF receptors, Astressin-B can prevent this process and maintain hair follicles in the growth phase.
Contact us
Astressin-B peptide represents an exciting research direction, indicating that targeted therapy for "stress-induced hair loss" is possible. However, there is still a long way to go before it becomes an approved, safe, and effective treatment method. If you wish to take the lead in research results, please contact us via email:sales8@faithfulbio.com
