B7-33 peptide

Xi'an Faithful BioTech Co., Ltd: Your Trusted B7-33 peptide Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd specializes in supplying high-quality peptides, and B7-33 peptide is one of the latest peptide products. With our supply chain advantage, we can provide most mainstream peptide products and also offer peptide customization services. With excellent product quality, we have gained a group of loyal customers. Welcome customers in need to inquire.

B7-33 peptide Introduction

B7-33 peptide is an innovative single chain relaxin family peptide receptor 1 (RXFP1) agonist. It is composed of a single chain structure of only 27 amino acids, with a molecular weight of approximately 2987.5 g/mol. B7-33 activates the signal transduction of relaxin peptide receptor 1 by preferentially modulating kinase extracellular signaling with phosphorylated mitogen activated protein kinase. In animal model experiments, it can be concluded that B7-33 can alleviate myocardial cell death and endoplasmic reticulum stress, protect cardiac function, and have a protective effect on acute myocardial injury in mice. As a research grade raw material, its high purity makes it an ideal tool for studying cardiovascular and fibrotic diseases.

Specifications

Application area

Mainly used in the following scientific research:

• Research on the mechanism of cardiovascular disease

Used to study the mechanism of cardiac protection, reduction of infarct size, and improvement of ventricular remodeling after acute myocardial infarction (ischemia-reperfusion injury).

• Anti fibrosis

In the study of the reversal mechanism of fibrosis in organs such as the heart, kidneys, and skin, especially in reducing left ventricular fibrosis in cardiomyopathy models, it is of great research value.

• Diseases related to pregnancy

Can be used for animal model evaluation of treatment plans for preeclampsia (gestational hypertension).

• Vascular function

It is also used in experiments to improve vasodilation function, reduce inflammatory factors such as TNF alpha, and oxidative stress levels.

Main Advantages of B7-33 peptide

• Compared to natural relaxants, this single chain structure is easier to synthesize, with small differences between batches of finished products and greater stability.
• Prioritize activating the pERK pathway for anti fibrosis and heart protection, while minimizing side effects.
• At extremely low doses (as low as 0.25 mg/kg/day in animal experiments), significant cardiac protection and anti fibrotic effects can be demonstrated, with good results.
• Our B7-33 peptide purity (HPLC) can reach over 95% -98%, meeting scientific research needs.

Contact us sales1@faithfulbio.com or Whats App：+86 17782784795

Why choose us

• B7-33 peptide abandons the complex double chain structure of natural Relaxin and chooses a single chain structure, but it is more effective because we have precisely targeted its specific amino acid sequence (27 amino acids) and spatial conformation, ensuring that it can accurately activate the RXFP1 receptor.
• Provide detailed COA analysis certificate for the goods, and the product quality can be seen.
• We have a stable first-hand raw material channel, which can support the exploration from milligram level experiments to the subsequent expansion of preclinical research dosage. We are your reliable partner behind scientific research.

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FAQ

Q1:Is B7-33 stable in serum?

A1:The half-life in serum is relatively short (about 6 minutes in vitro), but if lipidation (L-B7-33) or PEG modification is performed, the half-life in vitro can be significantly prolonged.

Q2:Is "net peptide content" and "purity" the same thing in peptide powder?

A2:No. Purity (HPLC) refers to the proportion of the target peptide in the total peptide; The net peptide content refers to the actual weight percentage of peptides in peptide salt (such as acetate/TFA salt) dry powder, and the net peptide content is generally lower than the purity value.

Q3:What are the functional differences between B7-33 and traditional Relaxin 2?

A3:Both activate the RXFP1 receptor, but B7-33 is a biased ligand. It preferentially activates the downstream ERK1/2 signaling pathway, rather than the cAMP pathway, which is safer.

Contact US

High quality B7-33 peptide helps you make breakthrough discoveries.  Contact us sales1@faithfulbio.com or Whats App：+86 17782784795.