Estradiol micronized powder
CAS. NO:50-28-2
MF.no:C18H24O2
Other names:Estradiol micronized powder;β-Estradiol;Dihydrofolliculin;Estradiol;17beta-Estradiol;Estradiol
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Estradiol micronized powder Manufacturer & Supplier
Estradiol micronized powder can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome and prostate cancer. API Estradiol powder can promote and regulate the normal growth of female sexual organs and secondary sexual characteristics, promote the maturity and growth of mammary ducts, and help to locate. Estradiol can also be used in biochemical research, and it is the most active and important component of estrogen.Estradiol provided by Xi'an Faithful BioTech Co., Ltd. is a white or milky odorless crystalline powder, which is the basic structure for the production and preparation of various estrogen intermediates.
What is Estradiol micronized powder?
Estradiol is one of the three common estrogens in the human body and an important indicator in gonadal hormone testing. Mainly generated by ovarian follicles, corpus luteum, and placenta during pregnancy. Checking the levels of estradiol in blood and urine has certain value in diagnosing endocrine and gynecological diseases such as precocious puberty and developmental disorders. In the process of human growth and development, it can promote the development of female reproductive organs, maintain secondary sexual characteristics and reproductive functions, as well as some very important non reproductive functions. Although both men and women have this estrogen, its levels are much higher in women. And estradiol micronized powder usually refers to the process of crushing pharmaceutical raw materials particles into smaller particle sizes through technology, thereby significantly increasing their total surface area. This is because as a natural estrogen, estrogen has relatively fewer adverse reactions. Through micronization, different finished products can be made, which better simulates physiological states and improves the absorption efficiency of estradiol raw materials.
Specifications
Item | Specifications | Results |
Appearance | White or creamy white crystalline powder | Conform |
Identification | Infrared Absorpion | Positive |
Melting point | 173 ~ 179℃ | 175.1℃ |
Specific rotation | +76~ +83° | +79.08° |
Water | ≤3.5% | 0.79% |
Loss on drying | ≤0.5% | 0.16% |
Related substances | any individual impurity ≤0 . 5% total impurities ≤ 1 . 0 % | Pass |
Residual solvents | ethanol < 0.5% | Pass |
Burning residue | ≤0.2% | 0.18 % |
Sulphated ash | ≤0.1% | 0.1% |
Particle size | 95 % pass 20μm | Pass |
Assay | 97.0 ~ 103.0% | 99.3% |
| Conclusion： | Conform with enterprise specification （USP 41）. |
Why Choose Us?
1. Uncompromising Purity and Stringent Quality Control >99.5% Purity Guaranteed:
Our Estradiol Micronized Powder is synthesized to meet the highest pharmacopeial standards (USP/EP). Every batch is rigorously tested to ensure exceptional chemical purity, providing a reliable and consistent foundation for your formulations.
2.Full Traceability & Comprehensive Documentation:
We provide complete transparency with Certificates of Analysis (CoA) and full regulatory support documentation, simplifying your quality assurance and regulatory submission processes.
3. Superior Micronization for Enhanced Bioavailability Engineered for Performance:
We don't just supply Estradiol; we engineer it. Our advanced micronization technology precisely controls particle size distribution, creating a powder with optimal surface area.This controlled micronization is critical for improving the dissolution rate and bioavailability of your final product，it also means more predictable pharmacokinetics and enhanced therapeutic outcomes for the end-user.
4. A Secure and Reliable Supply Chain Global Manufacturing Excellence:
Our state-of-the-art cGMP-compliant facilities ensure robust and scalable production. You can count on us for a consistent, uninterrupted supply to keep your production lines running smoothly.
5.Risk Mitigation:
We have a diversified and resilient supply chain, minimizing the risk of shortages and delays. Choosing us means choosing stability and predictability for your long-term product planning.
6. Expertise and Partnership Technical Collaboration:
Our team of expert scientists and engineers is your extended resource. We offer unparalleled technical support, from formulation advice to troubleshooting, ensuring our API integrates seamlessly into your development process.
7.Customization Capabilities:
We understand that one size does not fit all. We have the flexibility to discuss custom micronization profiles and specifications to meet the unique needs of your innovative pharmaceutical raw materials delivery system.
If you have any questions about the above estradiol micropowder, please write to me by email：sales8@faithfulbio.com.
Dietary Recommendations for Estradiol Deficiency:
1. Consume more foods rich in isoflavones, such as soy products (tofu, soy milk) and flaxseed.
2. Increase your intake of foods rich in omega-3s, such as salmon, trout, and flaxseed oil.
3. High-fiber foods: Eat more vegetables, fruits, and whole grains to promote gut health.
4. Moderate intake of healthy fats, such as olive oil and nuts, to support hormone health.
5. Limit processed foods and sugar: Reduce sugar intake to prevent hormone fluctuations.
Quality Control:
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FAQ
Q1: What is the primary particle size distribution of your micronized Estradiol powder?
We tightly control our micronization process to achieve a target particle size distribution primarily within the 1-10 microns range. This optimal size maximizes the surface area, which is critical for enhancing dissolution rates and ensuring consistent bioavailability in the final dosage form. A detailed Particle Size Distribution (PSD) report is available for each batch upon request.
Q2: What is the guaranteed purity of your Estradiol Micronized Powder, and which pharmacopeial standards do you comply with?
We guarantee a minimum purity of >99.5% for our Estradiol Micronized Powder. Our product is fully manufactured and tested in compliance with the latest USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs. Comprehensive testing includes assays for related substances, residual solvents, and heavy metals.
Q3: What is the recommended storage condition to maintain the stability and shelf life of the powder?
To ensure long-term stability and preserve its physicochemical properties, we recommend storing the Estradiol Micronized Powder in a cool, dry place at 15-25°C, in its original, tightly sealed container, protected from light and moisture. Under these conditions, the standard shelf life is 36 months from the date of manufacture.
Q4: How does your micronization process ensure batch-to-batch consistency?
Consistency is paramount. We employ state-of-the-art, validated jet-mill micronization technology with in-process controls that continuously monitor and adjust key parameters (e.g., feed rate, pressure). This closed-loop system, combined with rigorous final product testing (including PSD), guarantees exceptional uniformity and reproducibility across all production batches.
Q5: Can you provide custom micronization specifications for our unique formulation needs?
Absolutely. We offer custom micronization services and are ready to collaborate with you to achieve a specific particle size profile tailored to your unique delivery system, whether it's for direct compression, topical formulations, or other advanced applications. Please contact our technical sales team to discuss your specific requirements.
Q6: What is the lead time for samples and bulk orders?
Samples: Evaluation samples are typically available and can be shipped within 3-5 business days after receiving your request.
Bulk Orders: Standard lead time for commercial bulk orders is 4-6 weeks. We prioritize orders and can often accommodate rush requests based on inventory and production schedule.
Q7: What are the packaging options available?
Standard packaging is in double polyethylene bags inside a sealed HDPE drum to ensure protection from moisture and contamination. We offer a range of sizes, from 1kg bags to 10kg drums, and can discuss alternative packaging solutions if required.
Q8: How do you handle the safety and handling of this potent compound?
Estradiol is a potent hormone and should be handled with care. We provide detailed Handling Instructions and Safety Data Sheets (SDS) with each shipment. We recommend engineering controls (e.g., laminar flow hoods) and the use of appropriate Personal Protective Equipment (PPE) such as gloves, lab coats, and safety glasses to prevent inhalation and dermal exposure during handling.
Contact us
We know that when you start to pay attention to estradiol or hormone replacement therapy (HRT), your heart may be full of questions and expectations. Whether it is to relieve hot flashes and night sweats in menopause, improve the health of urogenital tract, or make plans for long-term bone and cardiovascular health, this is an important health journey. And we cherish your every inquiry. Your health and privacy will be strictly protected, and all conversations will be kept confidential. We are committed to providing you with a safe, professional and supportive environment to discuss your healthy future together.
If you are interested in learning about our Estradiol Micronized Powder, please leave us a message by email. Our email address is:sales8@faithfulbio.com
Let our company use professional knowledge and considerate support to become your trusted partner in this journey.
