Synonym:Thymosin alpha1 (cattle);Thymosin alpha1 (human);Thymosin alpha1 (ox);PubChem ID: 16130571;The thymus method sheen;Thymosin Alpha 1;Thymalfansin
CAS NO.:69440-99-9
EINECS NO.:1592732-453-0
Molecular Formula:C129H215N33O55
Purity & Grade: 99%; Medicine grade
Character:White Powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months" data-aw-url="https://www.faithfulbiochem.com/steroid-raw-powder/thymalfasin-peptide-powder/" title="Thymalfasin peptide powder">
Xi'an Faithful BioTech Co., Ltd. sells high quality Thymalfasin peptide powder. Xi'an Faithful With strong R&D and production capabilities, we can provide customized chemical powder products according to customers' special requirements. From the design of product ingredients, performance optimization to packaging form, all can be customized and produced according to the individualized needs of customers, providing one-stop solutions for customers and helping them achieve better results in their specific application fields.
Thymalfasin peptide powder is a protein and polypeptide hormone with immune-enhancing functions produced by the superficial cortical and medullary epithelial cells of the thymus. It is an acidic polypeptide composed of 28 amino acids and serves as a biological response regulator with a wide range of biological activities. Clinically, it is mainly used in the treatment of immune deficiencies, viral infections, and tumors. It is a confirmed first-line drug for the treatment of hepatitis B and can also be used as an adjuvant drug for vaccines, with remarkable therapeutic effects. It has the advantages of extremely high activity, relatively few toxic and side effects, and a wide range of indications. Thymalfasin enhances the function of P cells, promotes lymphocyte generation in the body, regulates the proportion of P cell subsets and U cell differentiation and antibody production, stimulates the production of other antiviral lymphokines and macrophages and enhances phagocytic function, thereby improving the cellular immune system function of cancer patients. It can also eliminate bacteria, fungi and viruses in the body.
ltems | Specification | Results |
Appearance | White or almost wnite powder or loose lump | Conforms |
Solubility | Insoluble in acetontrile,gther and chLaruform,slighy soluble in water,solutken trifluoroacetic acL | Conforms |
Specific optical rotation | -100°to-110(Anhydrous and acetic acid-free substance) | -108.2° |
Identification | (1)The chemical identification reaction of the substance should be blue-purple(Positive reaction) | Conforms |
(2)The retention time of the principal peak of the test solutior corresponds to that of the reference solution,as obtained in the Assay | Conforms | |
(3)The molecular weight measured by mass spectrometry should be 3108.3±1 | 3108.7 | |
Amino acid analysis | Aspartic acid:3.4~4.6 | 3.92 |
Glutamic acid:5.4~6.6 | 5.79 | |
Serine:2.4~3.6 | 2.55 | |
Threonine:2.4~3.6 | 2.70 | |
Alanine:2.7~3.3 | 2.97 | |
Valine:2.4~3.6 | 2.59 | |
Leucine:0.8~1.2 | 1.03 | |
Purity | ≥98.0% | 99.6% |
Conclusion | Conform with enterprise specification |
Good safety: Thymalfasin is a 28-amino acid sequence precisely synthesized through biotechnology, which is completely consistent with the structure of thymosin α1 naturally existing in the human body. As a chemically synthesized polypeptide, it has higher purity and stricter impurity control. Compared with some other immunomodulators, the probability of allergic reactions is extremely low.
High biological activity: Its structure is consistent with the natural active ingredients of the human body, which can precisely simulate the body's own immune regulation mechanism and comprehensively act on the core links of cellular immunity. It has high biological activity, a clear mechanism of action, and a remarkable effect in enhancing the body's immunity.
Stable market supply: We have a stable production and supply capacity, which can ensure an adequate supply of goods. Supply will not be restricted due to regional differences or other factors, which helps to ensure the continuity of patients' treatment.
Chronic hepatitis B
Thymalfasin is an important immunomodulator in the antiviral treatment of chronic hepatitis B. Its aim is to help patients achieve higher HBeAg serological conversion rates, HBsAg clearance rates and serological conversion rates, improve liver function indicators (such as ALT and AST), and possibly reduce the risk of liver cirrhosis and liver cancer. For some patients who have a poor response after standard antiviral treatment or a high risk of recurrence after drug withdrawal, the combined use of Thymalfasin can be used as a treatment option.
Chronic hepatitis C
In combination with direct antiviral drugs, it is used for certain specific genotypes (such as genotype 1) or patients with chronic hepatitis C accompanied by liver cirrhosis to enhance the immune response and increase the rate of sustained virological response (SVR). For some patients with refractory or recurrent chronic hepatitis C, combined use can be considered.
Adjuvant therapy for malignant tumors
Thymalfasin, as an immune enhancer, is often used in the adjuvant treatment of various malignant tumors, aiming to improve the weakened immune function of patients caused by the tumor itself or radiotherapy and chemotherapy. It can also be used for the adjuvant treatment of various solid tumors such as liver cancer, stomach cancer and colorectal cancer, as well as hematological tumors.
Other applications
If the immune function is weakened due to long-term use of immunosuppressants (such as after organ transplantation), short-term use under the guidance of a doctor can be adopted to assist in regulating the immune system.
For some refractory and severe infections (such as sepsis), on the basis of anti-infection treatment, it can be used as appropriate to enhance the body's anti-infection immune response.
A1: It mainly functions by precisely activating the core links of cellular immunity in the body, specifically including:
Activate T lymphocytes (such as CD4+ and CD8+T cells), promote their proliferation and differentiation, and enhance the immune killing ability; Activate natural killer cells (NK cells) to enhance their efficiency in recognizing and clearing abnormal cells (such as virus-infected cells and tumor cells); Promote the secretion of various cytokines (such as interferons, interleukins, etc.) by immune cells, further amplify immune response signals, and thereby comprehensively enhance the cellular immune function of the body.
A2: No.
Applicable situations: It is often used for patients with poor response to nucleoside (acid) analogues, high risk of recurrence after drug withdrawal, or those seeking a higher HBsAg clearance rate. It is mostly used in the form of "combination therapy".
Contraindications: Patients who are allergic to the drug ingredients, have severe liver or kidney dysfunction, have other serious underlying diseases, or have normal immune function and respond to single antiviral therapy may not be suitable for use.
A3: No.
Health supplements aim to "regulate physiological functions and supplement nutrition", and have no therapeutic effect on diseases.
Thymalfasin, on the other hand, targets "pathological immune dysfunction" (such as after viral infection or tumor treatment) and should be used within the framework of disease diagnosis and treatment. Healthy individuals do not need to and should not use it. Abuse may disrupt the normal immune balance.
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