Fenofibrate raw powder
CAS.NO:49562-28-9
structural formula:C20H21ClO4
EINECS.no:256-376-3
Other names:Fenofibrate;lf-178;lipantil;procetofen;sedufen;proctofene;
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Fenofibrate raw powder Manufacturer & Supplier
Fenofibrate raw powder is a fibrate derivative used to treat hypertriglyceridemia and dyslipidemia. It has been used since 1975 and is one of the most commonly used fibrates, with good efficacy and tolerability. The fenofibrate Xi'an Faithful BioTech Co., Ltd provide is a third-generation phenoxyaromatic acid lipid-regulating pharmaceutical raw material, which has significant lipid-regulating effects, including reducing plasma triglycerides (TG), lowering plasma total cholesterol (TC), and increasing high-density lipoprotein cholesterol (HDL-C) in patients with hyperlipidemia.
Fenofibrate raw powder Introduction
The lipid-lowering mechanism of Fenofibrate raw powder may be through its reaction with peroxisome proliferator activated receptor (PRAR α), which can regulate the gene expression of enzymes involved in fatty acid oxidation. In clinical practice, its main mechanism of action is to activate PPAR - α receptors, increase lipoprotein lipase activity, regulate lipoprotein metabolism, thereby enhancing the clearance of high triglycerides and lipoproteins, strongly reducing triglycerides, and moderately reducing cholesterol and enhancing high-density lipoprotein. The main effects include:
Reduce triglyceride (TG) levels
Reduce the levels of very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL)
Raise high-density lipoprotein (HDL) levels
Promote the catabolism of triglyceride rich lipoproteins
Specifications
Item | Specifications | Results |
Appearance | White powder | White powder |
Water | <10% | <10% |
Ashes | <2% | <2% |
Toxicity | LD50＞5000mg/kg（According to the classification of toxicity, it belongs to the non-toxic substances.） | Conforms |
Solubility | Solubility of 1g/100ml under appropriate conditions | Conforms |
Purity of raw powder (including stabilizers, etc.) (by HPLC) | ≥98% | 98.1% |
| Conclusion | Conform with enterprise specification （USP 41）. |
Why Choose Us?
Chose our Fenofibrate API because we have an internationally certified quality system, advanced production processes, and strict quality control standards, which enable us to provide customers with high-quality and cost-effective API products.
Our Fenofibrate raw material has passed international authoritative certifications such as FDA and EDQM. The product meets international pharmacopoeia standards such as CP, USP, BP, and EP, with a purity of ≥ 99% and impurity content controlled within 0.5%. All indicators are superior to industry standards.
With large-scale production capacity and process optimization, our product prices are competitive in the market, while providing comprehensive technical support services and stable supply guarantees, ensuring that customers obtain long-term stable partnership relationships. please leave a message via email: sales8@faithfulbio.com ,Welcome to the store for inquiries.
Other studies:
Fenofibrate raw powder not only has a lipid-lowering effect, but also has anti-inflammatory, fibrinogen lowering, and preventive neuroprotective effects, thus helping to reduce the risk of cardiovascular disease. The unique non lipid-lowering effects of fenofibrate also include enhancing insulin sensitivity, increasing bone density, improving microalbuminuria, and improving hyperuricemia. These effects can simultaneously improve the abnormal coexistence of multiple diseases in patients. Therefore, fenofibrate is particularly suitable for regulating dyslipidemia in patients with type 2 diabetes or metabolic syndrome. In addition, fenofibrate inhibits the expression of tumor necrosis factor alpha (TNF - α) and interleukin-6 (IL-6) in monocytes through PPAR - α receptors, and promotes tumor cell differentiation and apoptosis.
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FAQ
Q1: How effective is its voltage reduction?
Fenofibrate is mainly used for lipid regulation rather than blood pressure reduction. In terms of lipid-lowering, it can reduce triglycerides by about 35%, increase HDL by about 11%, and reduce LDL by about 20-25%. Field research shows that Fenofibrate raw powder can reduce the risk of non fatal myocardial infarction by 24% and decrease the need for coronary artery bypass surgery.
Q2: What impact does it have on liver function?
About 20% of patients experience transient mild elevation of serum transaminase levels after medication, but only 3% -5% of patients have transaminase levels more than three times normal. A small number of patients may experience clinically significant liver damage, including acute hepatitis, chronic hepatitis, and cirrhosis. Regular monitoring of liver function is required during medication.
Q3: How is it stored correctly?
It should be stored in a dark, sealed place, in a cool and dry place, away from direct sunlight and humid environments. It is recommended to store between 15 ° C and 30 ° C and keep out of reach of children.
Q4: What is its shelf life?
Usually 24-36 months, depending on the expiration date label on the product packaging. Expired pharmaceutical raw materials should not continue to be used.
Contact us
Fenofibrate API powder is used to treat hypercholesterolemia (IIa) in adults where dietary control therapy is ineffective, especially when blood cholesterol continues to rise after dietary control or when there are other risk factors for complications. If you have any research in this area, please leave us a message via email:sales8@faithfulbio.com.
