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Gemfibrozil powder

Product Name:Gemfibrozil
CAS.NO:25812-30-0
structural formula:C15H22O3
EINECS.no:247-280-2
Other names:GEMFIBROZIL;Gemcitabine intermediates;
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate:FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.

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  • Product Description

Xi'an Faithful BioTech Co., Ltd: Your Trusted Gemfibrozil powder Manufacturer & Supplier

Gemfibrozil powder is a non halogenated clofibrate based lipid-lowering drug that can effectively reduce the levels of total cholesterol, total triglycerides, very low-density lipoprotein cholesterol and triglycerides, low-density lipoprotein cholesterol and triglycerides in the blood, and increase the concentration of high-density lipoprotein cholesterol. The Gemfibrozil provided by Xi'an Faithful BioTech Co., Ltd has overcome the serious toxic side effects of traditional lipid-lowering pharmaceutical materials on the liver. Animal and clinical trials show that its blood lipid lowering effect is better than that of its homologues, and it helps to reduce the incidence rate of myocardial infarction. It is a rare product that can effectively reduce TC, TG, LDL-C and increase HDL-C.  

Gemfibrozil powder Introduction

In recent years, it has been gradually recognized that the decrease of HDL-C (high-density lipoprotein cholesterol) in plasma is also a disorder of blood lipid metabolism. Therefore, some people suggested using the name lipid dyslipidemia, believing that it could more comprehensively and accurately reflect the state of lipid metabolism disorders, but at that time there were no relevant materials to solve this problem. However, the organic compound of Gemfibrozil powder, which appears as a white crystalline powder, solves this problem. Clinical studies have shown that it can promote the breakdown of surrounding fat, reduce liver uptake of free fatty acids and decrease the formation of triglycerides in the liver, inhibit the synthesis of very low-density lipoprotein and apolipoprotein, and reduce the production of very low-density lipoprotein. In addition, it can also reduce blood triglycerides and increase blood levels of high-density lipoprotein, slightly reducing blood concentrations of low-density lipoprotein cholesterol. However, in type IV hyperlipidemia, it may cause an increase in low-density lipoprotein. Clinically, it is mainly suitable for patients with severe type IV or V hyperlipidemia in hyperlipidemia, high risk of coronary heart disease, and ineffective treatment such as dietary control and weight loss. It is also applicable to patients with type IIb hyperlipidemia, high risk of coronary heart disease, diet control, weight loss, and other blood lipid regulating drugs that are ineffective.

Specifications

Item

SpecificationsResults

Appearance

White or almost white powder

Conform

Solubility

Soluble in organic solvents

Conform

Acetate Content (HPLC)

≤15.0%

1.2%

Water Content (Karl Fischer)

≤8.0%

1.2%

Content(HPLC)

≥98.0%

99.7%

Related Substance (HPLC)

Total lmpurities≤2.0%

0.3%

 

Largest Single Impurity≤1.0%

0.2%

Organic Solvent Residue

Acetonitrile≤0.041%

<0.041%

 

Dichloromethane≤0.060%

<0.060%

 

N,N-Dimethylformamide≤0.088%

<0.088%

ConclusionConform with enterprise specification (USP 41). 

Why Choose Us? 

You chose Gemfibrozil powder because we have the world's leading API production technology platform and strict quality management system. Our products have passed the international authoritative certifications such as FDA, EDQM and NMPA, ensuring that each batch meets the international pharmacopoeia standards such as CP, USP and BP. We adopt advanced synthetic process route, the product purity is over 99.5%, the related substances are controlled within 0.5%, and the key indexes such as loss on drying, ignition residue and heavy metals are all better than the industry standards; At the same time, we have established a perfect quality traceability system, and every link from raw material procurement to production, inspection, packaging and storage has been strictly controlled to ensure the stability and consistency of product quality; We also have a professional R&D team and strong technical support ability, which can provide customized services for customers, including customized requirements of different specifications and different packaging forms, as well as comprehensive services such as technical consultation and quality comparison research. In addition, we have a stable supply chain system and a global sales network, which can ensure timely delivery and rapid response to customer needs, and have market competitiveness in terms of price, providing customers with cost-effective product choices; Choose us, you will get not only high-quality products, but also long-term and stable cooperative partnership and all-round technical support services.My email is: sales8@faithfulbio.com ,Welcome to the store for inquiries.

What effect does gemfibrozil have on Alzheimer's disease?

Gemfibrozil raw powder, has shown potential value in the treatment of Alzheimer's disease (AD) in recent years. The research of Yao Yonggang, Kunming Institute of Zoology, Chinese Academy of Sciences, found that gemfibrozil, as a nuclear receptor peroxisome α(PPARA) agonist, can significantly improve the structure and function of damaged neurons in AD mice model by activating PPARA-mediated autophagy, and enhance the learning and memory ability of model mice. The research team believes that this depends on its ability to significantly increase the structural plasticity markers SYP and DLG4/PSD-95 of neurons in the cortex and hippocampus of AD mice, and significantly increase the density of dendritic spines of neurons in the hippocampus. Morris water maze experiment confirmed that gemfibrozil could significantly improve the spatial memory ability of AD model mice.

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FAQ 

Q1: How to adjust the dose for special people?
Patients with renal insufficiency need to adjust the dose according to creatinine clearance rate: mild renal insufficiency (Ccr 50-80ml/min) does not need to be adjusted; Moderate renal insufficiency (Ccr 30-50ml/min) is recommended to be 600mg; per day; Severe renal insufficiency (Ccr<30ml/min) is prohibited. Patients with hepatic insufficiency should be used with caution, and it is recommended to start with a small dose and closely monitor liver function. Elderly patients do not need to adjust the dose, but need to monitor renal function regularly.
Q2: How to detect the related substances of gemfibrozil?
Detected by high performance liquid chromatography (HPLC). The retention time of gemfibrozil peak value is about 15 minutes, and the resolution between gemfibrozil peak value and impurity peak I (relative retention time is about 0.8) should be greater than 2.0. The peak area of impurity I shall not be greater than 0.1% of the main peak area of the control solution, the peak area of other single impurities shall not be greater than 0.1%, and the total impurities shall not be greater than 0.3%.
Q3: What are its storage conditions?
It should be shaded, sealed and stored in a cool and dry place. The powder can be stored at room temperature for 3 years and at 4 C for 5 years. Its finished product can be preserved for 2 years at room temperature. The transportation condition is room temperature, avoiding high temperature and humidity.

Contact us

We are the world's leading supplier of gemfibrozil raw materials, and our products have passed international certifications such as FDA and EDQM, with stable and reliable quality and competitive price, and provide perfect after-sales service and technical support.If you hope to make achievements during this period, please leave a message, Our email address is:sales8@faithfulbio.com).

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