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Leflunomide API powder

Product Name:Leflunomide API powder
CAS NO.:75706-12-6
Molecular formula:C12H9F3N2O2
EINECS:616-254-6
Synonyms: 5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide;LEFLUNOMIDE
Shelf life: 24 months
Purity : 98% HPLC
Certificate:COA; HPLC; MSDS; TDS,etc.
MOQ : 1g;10g;100g
Shipping: DHL/FedEx/UPS/USPS Safe and fast delivery
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
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  • Product Description

Xi'an Faithful BioTech Co., Ltd: Your Leflunomide API powder Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd is a leading supplier of Leflunomide API powder. Specializing in active pharmaceutical ingredients, pharmaceutical intermediates, fine chemicals, veterinary drugs, etc., we are a professional chemical raw material company integrating production and sales. Adhering to the corporate philosophy of "striving for excellence and aiming to become world-class", we regard quality as the lifeblood of our enterprise. Our products are high in purity, low in impurities, guaranteed in quality, and offered at competitive prices, selling well in numerous countries such as the United States, Britain, Germany, and France.

Leflunomide API powder Introduction

The chemical name of Leflunomide API powder is N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide. It appears as white crystals or powder, is odorless, and meets the standards of the Chinese Pharmacopoeia, with a dry content of 98.0% to 102.0%. As a classic isoxazole immunosuppressant, its core mechanism of action is to inhibit dihydroorotate dehydrogenase, block pyrimidine synthesis, and subsequently suppress lymphocyte activation, exerting significant immunosuppressive and anti-inflammatory effects. The Leflunomide API supplied by our company has undergone multiple rounds of sampling inspection, and its heavy metal, organic solvent residue, and related substances all meet the pharmacopoeial limit requirements. With high purity and strong stability, it is the core pharmaceutical raw material for the preparation of anti-rheumatoid preparations.

Specifications

Items

Specification

Result

Description

White to off-white crystalline powder

Conforms

Identification

similar with reference standard

Conforms

Melting range

164 to 168°C166 to 167°C

Loss on Drying

≤0.3%

0.15%

Residue on Ignition

≤0.1%

0.05%

Heavy metals

≤20ppm

<20ppm

 

Related compounds

Impurity A ≤0.1%

Impurity B ≤0.3%

Impurity C ≤0.1%

Individual impurity ≤0.1%

Total impurity ≤0.4%

Conforms

Assay

98.5% to 102.0%

99.7%

Conclusion

Conform with the enterprise standard .

Why Choose Us?

  • Stable and guaranteed supply: Directly connected to domestic manufacturing enterprises, with first-hand channels without intermediate markups, enabling direct delivery of stock and customized production, ensuring uninterrupted supply of all specifications from gram to ton levels;
  • Strict quality control and traceability: Each batch of Leflunomide API is provided with a complete COA full-item testing report, with multiple sampling inspections from raw material acceptance to warehouse delivery, ensuring that the product meets pharmacopoeia and customer-customized standards;
  • More efficient professional service: Our professional team provides one-on-one service, enabling us to quickly respond to customer needs. Additionally, we are familiar with the handling of import and export documents and logistics distribution processes, ensuring efficient delivery of goods;
  • Flexible cooperation and high cost-effectiveness: We support various cooperation modes such as sample procurement and long-term bulk cooperation. By leveraging our channel advantages, we offer cost-effective quotations and provide comprehensive after-sales technical support to address various issues in customer production and application.

Main applications

  • Leflunomide API, as a core raw material for immunomodulation and anti-rheumatism in the pharmaceutical field, occupies a pivotal position in the research and development of clinical prescription drugs and their industrial production. It is primarily suitable for the full-process production and preparation of various anti-rheumatism and immunomodulation prescription drugs. Its core application lies in the research and development of therapeutic preparations for clinically prevalent autoimmune joint diseases such as rheumatoid arthritis and psoriatic arthritis, as well as their large-scale production. This raw material exhibits strong adaptability and stable pharmacological activity. It can be used alone as a core active ingredient to prepare commonly used oral tablets, capsules, and other dosage forms in clinical practice. Alternatively, it can be scientifically combined with other anti-rheumatism and immunomodulation drugs to develop compound preparations according to individualized clinical medication needs, fully meeting diverse clinical medication scenarios and treatment requirements.
  • Meanwhile, as a classic isoxazole-based immunosuppressant raw material, it can also serve as a key effective ingredient, widely applied in the entire chain of therapeutic drug development, pilot scale optimization, and industrial production for refractory autoimmune diseases such as relapsing multiple sclerosis. With its excellent immunosuppressive and anti-inflammatory properties, it has become an indispensable and important basic raw material for the research, development, and production of various therapeutic drugs for autoimmune diseases in the pharmaceutical industry.

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Quality Control:

Leflunomide API powder

R&D Results:

Leflunomide API powder​​​​

Packaging and Transportation:

Leflunomide API powder

Leflunomide API powder

After-Sales Service:

Leflunomide API powder​​

Qualification Certification:

Leflunomide API powder

Leflunomide API powder​​

Exhibition:

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FAQ

Q1:What is the mechanism of action of Leflunomide API powder?

A1:Inhibits dihydroorotate dehydrogenase, which reduces the production of immune cells.

Q2:What are the main side effects of leflunomide?

A2:The most common side-effects of leflunomide are nausea (feeling sick), diarrhoea, mouth ulcers, weight loss, stomach pain, headache, dizziness, weakness, skin dryness, rashes and very rarely, minor hair loss. Also it may cause a slight rise in your blood pressure.

Q3:What is the water solubility of leflunomide?

A3:Leflunomide is insoluble in water.

Contact Us

We look forward to establishing a long-term and stable partnership with you, providing high-quality Leflunomide API powder and attentive services to support your pharmaceutical production and operation!We will be very glad to receive your inquiry sales1@faithfulbio.com .

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