Nicorandil API powder

Xi'an Faithful BioTech Co., Ltd: Your Trusted Nicorandil API powder Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd. sells high-quality Nicorandil API powder. Our company has established a flexible production capacity system with a single batch capacity of 300kg. We can flexibly accept orders ranging from 1kg R&D samples to ton-level commercial orders, and deliver regular orders within 7-10 working days. We have established a global warehousing network with warehouses in key markets in Europe, America, and Southeast Asia, enabling us to ship from the nearest location, significantly shortening delivery cycles and reducing transportation losses.

Nicorandil API powder Introduction

Nicorandil API powder active pharmaceutical ingredient (API) is a white to off-white crystalline powder primarily used in the manufacturing of medications for the treatment of chronic stable angina pectoris (chest pain). It is a unique dual-action vasodilator that combines the properties of a potassium channel activator and a nitric oxide donor. It activates ATP-sensitive potassium channels in vascular smooth muscle cells, leading to hyperpolarization and relaxation of arteries. This reduces afterload and improves blood flow to the heart muscle. It acts as a nitric oxide donor, increasing levels of cyclic GMP (cGMP) in smooth muscle, which further enhances vasodilation, particularly in the veins, reducing preload and the heart's workload.

Email: sales9@faithfulbio.com

COA

Why Choose Us?

1. Strict Quality Control and Assurance: We implement robust quality assurance and control protocols to ensure that every batch of product undergoes internal laboratory testing and guarantees batch-to-batch quality consistency. This means our Nicorandil API powder has high purity (typically greater than 99%) and stable performance.

2. Reliable Supply Chain and Timely Delivery: We have a reliable supply chain management system that ensures timely and safe delivery of Nicorandil API powder, guaranteeing uninterrupted production processes.

3. Customized Services: In addition to standard products, we also offer the capability to customize APIs to meet diverse quality standards and specific formulation needs.

Application Areas

• Symptomatic treatment of stable angina: This is Nicorandil's primary application. It reduces and prevents chest pain attacks by relaxing and dilating blood vessels, increasing blood and oxygen supply to the heart muscle.

• Reduction of the risk of acute coronary syndrome (ACS): Long-term use of Nicorandil helps reduce the risk of acute coronary syndrome.

• Variant and unstable angina: In practice, it is also used to treat variant angina caused by coronary artery spasm, as well as certain types of unstable angina.

Quality Control:

R&D Results:

Packaging and Transportation:

After-Sales Service:

Qualification Certification:

Transaction Feedback:

Exhibition:

FAQ

Q1: What is the mechanism of action of Nicorandil API powder?

A1: Nicorandil is a dual-action vasodilator. It works through two main mechanisms:

Activation of ATP-sensitive potassium channels (K-ATP): This leads to relaxation of vascular smooth muscle, dilation of coronary and peripheral blood vessels, thereby increasing the oxygen supply to the myocardium.

Providing nitric oxide (NO): The nitrate ester group in its structure gives it a nitrate-like effect, releasing nitric oxide, activating guanylate cyclase, leading to venous dilation, and reducing cardiac preload and afterload.

These two mechanisms work synergistically to effectively relieve angina symptoms.

Q2: How stable is Nicorandil API powder?

A2: Nicorandil API powder is very sensitive to moisture, light, and high temperatures. In its solid crystalline state, it is stable in extremely dry environments. However, in humid environments, even short-term exposure to room temperature can easily cause hydrolytic degradation, leading to a decrease in the content of the active ingredient.

Therefore, strict storage requirements must be followed:
Store away from light.
Store in a dry, cool, and well-ventilated place.

Q3: Which one is the most common side effect associated with Nicorandil API powder?

A3: Headache is the most commonly reported adverse event (up to 36.4%).

Contact Us

Nicorandil API powder is in critical shortage! Heavy metals ≤10ppm, total impurities ≤0.5%. Contact us immediately to secure supplies and avoid production disruptions! Please contact my email sales9@faithfulbio.com.

Email: sales9@faithfulbio.com

Let's work together to turn your goals into reality.