Nifuroxazide API powder
CAS NO.: 965-52-6
Molecular formula:C12H9N3O5
EINECS:213-522-0
Synonyms:(nitro-5’furfurylidene-2’)hydroxy-4benzhydrazide
Purity : 98% HPLC
Certificate:COA; HPLC; MSDS; TDS,etc.
MOQ : 1g;10g;100g
Shipping: DHL/FedEx/UPS/USPS Safe and fast delivery
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Nifuroxazide API powder Manufacturer & Supplier
Xi'an Faithful BioTech Co., Ltd is a high-quality supplier of Nifuroxazide API powder. We are a professional service provider specializing in various pharmaceutical raw materials, veterinary drug powders, and chemical intermediates. Faithful F is based in the domestic and international health industry, relying on professional industry knowledge and mature supply chain system, committed to providing high-quality product solutions for pharmaceutical, veterinary and feed additive production enterprises. We always adhere to the business principle of "integrity-based, quality first", strictly screen supply channels, and ensure that every link of the product from production to delivery meets industry standards. By continuously optimizing our logistics system and providing meticulous customer service, we have won the trust of our partners.
Nifuroxazide API powder Introduction
The chemical formula of Nifuroxazide API powder is C12H9N3O5. The product is a yellow or bright yellow fine powder with high purity, usually with a content of over 98%. It is slightly soluble in water and has a melting point of 281-283 ° C. As a nitrofuran antibacterial agent, Nifuroxazide is recognized as a new and efficient feed additive for animals in Europe. Its core mechanism of action is to inhibit the normal redox reactions of bacteria, disrupt the synthesis of bacterial cell walls, and achieve broad-spectrum antibacterial effects. It not only has strong inhibitory effects on Gram negative bacteria such as Escherichia coli, Salmonella, and Pasteurella, but also has significant effects on some Gram positive bacteria, coccidiosis, and white blood cell protozoa. The biggest feature of this product is that it is almost not absorbed in the intestine, and can stay in the intestine for a long time to exert bactericidal effect, and then be excreted with feces. Therefore, the drug residue is extremely low, the safety is high, and there is no cross resistance with other antibiotics.
Specifications
Items | Specifications | Results |
Appearance | Bright yellow crystalline powder | Bright yellow crystalline powder |
Solubility | Practically insoluble in water, slightly soluble in 96% ethanol, practically insoluble in methylene chloride | Conforms |
Loss on drying | 0.5% Max | 0.21% |
Heavy metal(Pb) | 0.002 %Max | Complies |
Sulphated ash | 0.1% Max | 0.02% |
Identification By IR | The IR spectrum matches Nifuroxazide standard spectrum | Complies |
Impurity A | 0.05% Max | 0.02% |
Related substance (the ratio of area)
| Relative retention : with reference to nifuroxazide (retention time =about 8 min) Impurity A =about 0.36 and 0.39 Impurity E =about 0.9 Impurity B =about 1.2, Impurity C =about 2.6, Impurity D = about 3.4. | Conforms
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Impurity peak area : impurity B ,C, D: for each impurity ,not more than 0.6 times the area of the principal peak Impurity E: NMT 0.3% Impurity B, C, D: each impurity NMT 0.3%, and NMT one such peak has an area greater than 0.1%.and NMT one such peak has an area greater than 0.2 times the area of the principal peak. Unspecified impurities: each impurity NMT 0.1% Sum of impurities other than E: 0.5% | ||
UV.Absorption | The specific absorption at about 367nm is between 940-1000 | Conforms |
RESIDUAL SOLVENTS | Methanol ≤ 0.3% Alcohol ≤ 0.5% Acetic acid ≤ 0.5% NMP ≤0.05% | Not Detected 0.02% Not Detected Not Detected |
Granularity | 30μm-60μm | Conforms |
Assay ( on dried ) | 98.5%-101.5% | 99.8% |
Conclusion: Conforms with the EP7.0 standard. | ||
Why Choose Us?
In the fiercely competitive raw material supply market, choosing reliable partners is the key to ensuring your production stability.
- Stable and reliable supply of goods: We have established long-term and stable strategic partnerships with multiple qualified and mature source manufacturers in China. No matter how volatile the market is, we can ensure the continuous and stable supply of Nifuroxazide API, avoiding any impact on your production plan due to stockouts.
- Strict quality control system: We deeply understand that 'quality is the lifeline of an enterprise'. For every batch of Nifuroxazide API powder entering and leaving the warehouse, we strictly adhere to industry testing standards. The purity of the product remains stable at around 99%. We can provide detailed Certificate of Analysis (COA) along with the goods to ensure stable quality between batches, allowing you to buy and use with peace of mind.
- Flexible packaging and logistics: In order to meet the needs of different customers, we offer diversified packaging specifications, whether it is 1kg aluminum foil bags for experiments or 25kg cardboard drums for production, we can supply them. In terms of logistics, we choose the most cost-effective shipping solution for you to ensure that the products are safely and quickly delivered to your hands.
- Professional pre-sales and after-sales: After placing an order, we will provide one-on-one follow-up services to handle bills, shipment tracking, and other matters, making your procurement process worry free and effortless.
Main applications
Nifuroxazide is widely used in animal husbandry due to its excellent antibacterial performance and extremely high safety, mainly reflected in the following aspects:
- Prevention and treatment of intestinal diseases: specifically used to prevent and treat animal intestinal infections and dysentery caused by Escherichia coli, Salmonella, Pseudomonas aeruginosa, Proteus mirabilis, and Staphylococcus aureus. It can effectively prevent common diseases such as piglet dysentery and chick dysentery, and significantly improve the survival rate of young livestock and poultry.
- Promoting growth and feed conversion: As a feed additive, Nifuroxazide can improve animal intestinal health and promote nutrient absorption. Experimental data shows that adding an appropriate amount of nitrofuran hydrazide to feed can increase the daily weight gain of piglets by more than 10%, reduce the feed to meat ratio of growing pigs by 10.1%, increase the daily weight gain of broiler chickens by more than 7%, and promote skin pigment deposition in broiler chickens, improving product appearance.
- Aquaculture application: In the field of aquaculture, this product has specific effects on intestinal and systemic diseases caused by bacteria, Vibrio, and fungi in fish, shrimp, and crabs. Its excellent drug sensitivity in water is much higher than other conventional antibiotics, making it an ideal choice to replace products such as enrofloxacin.
- Prevention and treatment of protozoan diseases: In addition to antibacterial effects, it can also effectively prevent and treat chicken coccidiosis, as well as diseases such as white crown disease and cecal hepatitis caused by white blood cell protozoa, achieving multiple effects with one drug.
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FAQ
Q1:Is nifuroxazide good for diarrhea?
A1:Nifuroxazide was therefore confirmed as an effective treatment for acute diarrhoea that can be administered before the results of the microbiological stool. In addition, it was also shown to be safe medicine with no side effects
Q2:What is the mechanism of action of Nifuroxazide?
A2:It is a specific STAT3 inhibitor with cell permeability and oral activity. It is an effective antidiarrheal drug that can inhibit the activation of STAT3/3/5 transcriptional activity in cells (IC50 value of 3 µ M). By downregulating JAK kinase autophosphorylation, it hinders STAT3 constitutive phosphorylation, inhibits the signal transduction of STAT transcription factors, reduces the survival activity of myeloma cells, and has anti-tumor activity.
Q3:Is Nifuroxazide API powder soluble in water?
A3:It is slightly soluble in water.
As a key component in improving the efficiency of aquaculture, Nifuroxazide API powder looks forward to becoming a trusted partner on your career development path with the highest quality products and sincere services. If you need to inquire or obtain samples, please feel free to contact us at any time,: sales1@faithfulbio.com.
