Unifiram powder
CAS. NO:272786-64-8
MF.no:C13H15FN2O3S
EINECS.no:1532714-185-1
Other names:Unifiram;DM232;DM-232
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Unifiram powder Manufacturer & Supplier
Unifiram powder can induce a lasting increase in the amplitude of field-excited postsynaptic potential (fEPSP) in hippocampal CA1 region of rats (EC50= 27 nM), and increase the release of acetylcholine (ACh) in cerebral cortex of rats. Unifiram powder provided by Xi'an Faithful BioTech Co., Ltd. is a powerful cognitive enhancer, and its efficacy is four orders of magnitude higher than that of piracetam. Although these compounds do not show affinity in the study of binding with the most important central receptors or channels, they can prevent amnesia caused by the regulation of various nerve transmission systems.
Unifiram powder Introduction
Unifiram powder is an nootropic Intermediate raw material. Studies have shown that it can increase the release of acetylcholine (ACh) in the cerebral cortex of rats and induce a persistent increase in the amplitude of field excitatory postsynaptic potential (fEPSP) in the CA1 area of the rat hippocampus (EC 50 = 27 nM). At a concentration of 1 µM, it does not bind to serotonin (5-HT), dopamine or GABA receptors. Unifiram (0.1mg /kg) can improve the memory of non-memory-impaired rats in social learning tests, and at the same time prevent memory deficits caused by AMPA/ sea human glutamate receptor antagonist NBQX. When administered at a dose of 0.01 mg/kg, it can prevent memory deficits caused by anticholinergic products or α 2-adrenergic receptor agonists in mouse passive avoidance tests.
Specifications
Item | Specifications | Results |
Appearance | White to off white powder | Conform |
Odor | Characteristic | Conform |
Melting point | ≥171° | 173° |
Residue on ignition | ≤0.1% | 0.05% |
LOD | ≤0.5% | 0.21% |
Water | ≤1% | 0.03% |
Related Related | Single impurity≤0.5% Total impurity≤1.0% | Conform |
Heavy Metal | ≤10 ppm | ＜10ppm |
Total of bacteria | ≤1000 cfu/g | Conform |
Fungi | ≤100 cfu/g | Conform |
Assay | ≥98.5% | 99.1% |
| Conclusion： | Conform with enterprise specification （USP 41）. |
Why Choose Us?
In the field of cognitive enhancement, choice is more important than anything else. Facing many suppliers, we provide far more than products, but all-round trust and guarantee.
1. Extreme purity: We carry out strict third-party laboratory tests on each batch of Unifiram and Sunifiram, and provide a certificate of purity (CoA) to ensure that the research materials you obtain meet the highest standards.
2. Professional support: We have a professional knowledge team to provide you with professional information about the mechanism and application of drugs to help you make informed research decisions.
3. Reliable logistics: We ensure a stable and transparent supply chain and provide safe and fast global transportation, so that you have no worries.
Based on this, we recommend and provide you with two highly effective cognitive enhancement compounds. Experiments show that both of them can increase the release of acetylcholine from rat cerebral cortex, and also support the hypothesis that AMPA receptors play a role in cognitive enhancement.
1. unifiram: It is famous for its extremely high efficacy (the research shows that its efficacy may be 1000 times that of traditional intelligence drugs), and it is an ideal research object to explore the mechanism of memory formation and neuroprotection. The latest research shows that it can also increase the amplitude of fEPSP in rat hippocampal slices.
2. Sunifiram : A classic acetylcholine substance, which has important research value in improving cognitive clarity and attention.
Choosing us means that you have chosen a partner who will never compromise on quality, knowledge and reliability. We are committed to providing you with the purest and most efficient Unifiram and Sunifiram to help you advance your research safely and effectively.Our email address is: sales8@faithfulbio.com. Welcome to write to us.
Development prospects
Unifiram has been shown in animal studies to have anti-amnesia and other effects, and its efficacy far exceeds that of piracetam. According to relevant literature, it is known that many compounds with related functions have been modified based on this product, such as sunifiram (DM-235) and sapunifiram (MN-19). In addition, Unifiram powder has two enantiomers, among which the dextrorotatory isomer has higher activity. In the future, it is highly likely that structural purification will be carried out to obtain effective components with better effects and fewer side effects. The latest research currently shows that it can shorten the duration of hypnosis induced by certain anesthetic products without compromising motor coordination. Although this product has a good effect and a promising future, it lacks research on human and long-term toxicity. If your company can persist in and solve these problems, it will occupy a place in the market of educational products in the future.
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FAQ
Q1: How many inhibitors should be added in cell experiments?
It is recommended to refer to the experimental literature of the same model. In addition, it is necessary to construct a dose-response curve through pre-experiments to determine the optimal working concentration (concentration gradient). Similarly, the optimal incubation time (time gradient) should also be determined through time-process experiments. In addition, the dosage of inhibitors is influenced by multiple factors, including the accessibility of the target, cell permeability, incubation time, and cell type, etc. It is recommended to refer to the literature to determine the initial concentration of the inhibitor. If Ki or IC50 is provided in the literature, it is recommended to start at 5 to 10 times their reported values to achieve the best inhibitory effect on enzyme activity. If Ki or IC50 is unknown, the concentration of the inhibitor should be tested and the Ki value should be calculated using Mie kinetics. Usually, the solvent that dissolves the inhibitor is used as a control to eliminate the non-specific effects of the solvent.
Q2: What should I do if the product remains undissolved even when its solubility is lower than the maximum solubility specified in the instructions?
It is recommended to use some auxiliary dissolution methods, such as heating to 45°C or using ultrasonic waves to accelerate dissolution.
Q3: Why can't I see what's inside the small bottle when I receive the small-sized product?
Due to the small packaging size, the powder may be highly dispersed and adhere to the small bottles during transportation due to static electricity. Please centrifuge and add an appropriate solvent to ensure the product is fully dissolved and the stock solution is made.
Q4: How to choose the right solvent?
Common solvents include DMSO, water, ethanol, etc. Please select the appropriate solvent according to the reference value of solubility. If the inhibitor is soluble in DMSO, it is recommended to use freshly opened DMSO that has not absorbed moisture. If the inhibitor is soluble in water, it is recommended to use solvents such as sterile water, physiological saline, sterile PBS and culture medium.
Q5: How to dilute the working solution?
Calculate the dilution factor and volume of the required stock solution based on the concentration of the working solution. It is recommended to dilute it with solvents such as water, physiological saline, PBS or culture medium. For cell experiments, the culture medium is suitable. Slowly add the appropriate solvent to the stock solution until the required concentration of the working solution is reached. Gentle vortexing or pipetting helps to mix the solution evenly. Most of our compounds are lipophilic, and precipitation may occur when the working solution is diluted with PBS or culture medium. This is a normal phenomenon. The product can usually be completely dissolved through ultrasonic treatment. It is recommended to prepare and use the working solution immediately after dilution.
Inform us
If you are interested in obtaining the high-purity raw powder of Unifiram powder and Sunifiram powder provided by us, it will lay a solid foundation for your scientific research.
Please contact us: sales8@faithfulbio.com (e-mail)
It would be our pleasure if we could support you.
