Synonym:1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;17a-estradiol;α-Estradiol;epiestradial;17-α estradiol
CAS NO.:57-91-0
EINECS NO.:200-354-8
Molecular Formula:C18H24O2
Purity & Grade: 99%; Medicine grade
Character:White Powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months" data-aw-url="https://www.faithfulbiochem.com/steroid-raw-powder/17-estradiol/" title="17-α estradiol">
Xi'an Faithful BioTech Co., Ltd. sells 17-α estradiol. We have formed a technological advantage that is difficult for competitors to replicate by independently developing and optimizing product formulas (such as controlling impurities in high-purity powders) or innovating production processes (such as replacing intermittent production with continuous production to enhance efficiency and reduce energy consumption). For instance, fine chemical enterprises can avoid the homogenized competition in the mid-to-low-end market and enter the high-value-added market by developing high-purity (above 99.9%) pharmaceutical intermediates.
17-α estradiol is a type of estrogen that can cross cell membranes and bind to estrogen receptors in the cytoplasm to form complexes. The complex enters the cell nucleus, binds to chromatin, activates the transcription of corresponding genes, and thereby promotes the synthesis of DNA, RNA and specific proteins in cells. Estradiol has effects on both ERα and ERβ receptors. For the reproductive system, it promotes the development and function of the uterus, vagina, fallopian tubes and mammary glands. For bones, it inhibits bone resorption and increases bone density. For the cardiovascular system, it can lower cholesterol, dilate blood vessels and inhibit platelet aggregation. It has the effects of improving cognitive function, inhibiting neuronal apoptosis and regulating emotions on the central nervous system.
ltems | Specification | Results | |
Appearance | White or almost white crystalline powder. | Complies | |
Assay (HPLC, based on drying) | 98.5% ~ 101.0% calculated on | 99.55% | |
anhydrous basis | |||
Identification | Positive | Complies | |
Specific rotation | +53°~ -56° | +54.5° | |
Melting Point | 176-180 °C | Complies | |
Residue on Ignition | ≤0.1% | 0.05% | |
Water | ≤0.3% | 0.16% | |
Residual Ethanol | ≤0.5% | Complies | |
Heave Mentals | ≤10ppm | Complies | |
Total plate | <1000CFU/g | Complies | |
Yeast & Mold | <100 CFU /g | Complies | |
E. Coli | Negative | Complies | |
Salmonella | Negative | Complies | |
Conclusion | Conform with enterprise specification |
Hormone replacement therapy: Estradiol can be used to treat hypogonadism in women, after bilateral oophorectomy, atrophic vaginitis, vulvar dryness, perimenopausal syndrome, etc. It can relieve symptoms of estrogen deficiency such as hot flashes, sweating, and sleep disorders.
Contraception: It is a key component of compound hormonal contraceptives. By inhibiting the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), it suppresses ovulation and achieves the purpose of contraception.
Treatment of advanced prostate cancer: It can improve the symptoms and relieve pain of patients with advanced prostate cancer. However, estrogen therapy is usually added after testicular removal. Currently, this application is less common.
Preventing osteoporosis: It can prevent rapid bone loss caused by estrogen deficiency in the early stage of menopause and help maintain bone health.
Treating acne: For severe cases of acne in men, Estradiol can be used for treatment. Women can choose a combination of estrogen and progesterone preparations to treat acne.
Increase white blood cells: It can be used to treat leukopenia caused by chemotherapy or radiotherapy for malignant tumors, and has a significant effect of increasing white blood cells.
Postpartum milk return: Estradiol can help postpartum women return milk by regulating hormone levels and inhibiting milk secretion.
A1: In females, estradiol acts primarily as a growth hormone for the reproductive organs including the vagina, the fallopian tubes, the endometrium and the cervical glands. Estradiol also enhances growth of the womb's muscle layer, the myometrium.
A2: Positive indicators that HRT is working include: relief from hot flashes, improved sleep quality and a stabilized mood.
A3: Estrogen helps maintain pregnancy and stimulates fetal maturation. 17-α estradiol is essential for optimal bone growth and for healthy bones and joints. Osteoporosis, a bone disease characterized by loss of bone density, can occur with low estradiol levels.
Are you ready to use our high-quality 17-α estradiol? Contact our expert team today to discuss your needs and discover how Xi'an Faithful BioTech can support your business growth.
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