MSA-2 powder
CAS.NO:129425-81-6
molecular formula:C14H14O5S
English alias:MSA-2;MSA2;
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place;36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted MSA-2 powder Manufacturer & Supplier
MSA-2 is an oral non nucleotide STING agonist that binds to STING in a non covalent dimer form with nanomolar affinity. The EC50 values of MSA-2 powder for the STING subtypes WT and HAQ in humans are 8.3 and 24 μ M, respectively. The MSA-2 Standard test sample provided by Xi'an Faithful BioTech Co., Ltd showed anti-tumor activity in a mouse tumor model with the same gene. Research has shown that it can stimulate tumor secretion of interferon - β, induce tumor regression, have long-lasting anti-tumor immunity, and synergize with anti-PD-1.
MSA-2 powder Introduction
MSA-2 powder was identified in the phenotype screening of chemical inducers that promote the secretion of beta interferon. In cell-free assays, MSA-2 can bind to STING in both humans and mice. In tumor bearing mice, MSA-2 induces an increase in beta interferon in plasma and tumor through two administration routes. The well tolerated MSA-2 course induced tumor regression in mice carrying MC38 syngenic tumors. Most mice that showed complete regression were resistant to re inoculation of MC38 cells, indicating the establishment of a persistent anti-tumor immune response. In tumor models with moderate or poor PD-1 blockade response, the combination of MSA-2 and anti-PD-1 antibodies is superior to monotherapy in inhibiting tumor growth and prolonging survival.
Specifications
Item | Specifications | Results |
Appearance | White or almost white powder | White powder |
Purity (HPLC) | NLT 98.0% | 99.17% |
Related substances (HPLC) | Total impurities: NMT 2.0% Maximum single impurity: NMT 1.0% | 0.83% 0.34% |
Acetic acid Content (HPLC) | NMT 15.0% | N.D |
TFA Content (HPLC) | NMT 1.0% | N.D |
Water Content (K.F) | NMT 8.0% | 7.43% |
pH | Reported value(C=5mg/ml) | 8.50 |
Residue solvents(GC) | Acetonitrile NMT 410ppm Methanol NMT 3000ppm Methylene chloride NMT 600ppm Isopropyl ether NMT 5000ppm N,N-Dimethylformamide NMT 880ppm | 91ppm 26ppm N.D 13ppm N.D |
Oligomer | NMT 3.0% | N.D |
Bacterial Endotoxins | NMT 10 EU/mg | Conforms |
Microbial Limits | TAMC NMT 50 cfu/0.1g TYMC NMT 50 cfu/0.1g | Conforms Conforms |
| Conclusion： | Conform with enterprise specification （USP 41）. |
Why Choose Us?
When purchasing our MSA-2 powder, you will get three core advantages: first, excellent quality, the product has been multi-dimensionally purified and strictly controlled, and the purity is stable > 98%, ensuring the accuracy and reliability of experimental data; Second, technology empowerment, we provide professional application support and customized solutions to help you significantly improve research and development efficiency; The third is continuous guarantee. The mature supply chain system supports flexible production expansion, ensures super-high consistency between batches, and escorts your long-term projects.if you need to purchase MSA-2 peptide powder, please leave me a message. My email address is: sales8@faithfulbio.com
What are the latest research on MSA-2 powder ?
Structural studies have shown that MSA-2 binds to STING in a non covalent dimer form and exhibits a closed conformation. Each bound MSA-2 interacts with two monomers of STING homodimer. This simplest model can explain all observed equilibrium and kinetic behaviors of MSA-2: MSA-2 exists in solution in the form of monomers and non covalent dimers, in an equilibrium state with a strong preference for monomers; MSA-2 monomers cannot bind to STING, while non covalent MSA-2 dimers bind to STING with nanomolar affinity. The covalent coupling dimer of MSA-2 analogs exhibits nanomolar affinity for STING, further supporting this model.
Simulation and experimental analysis predict that as a weak acid, MSA-2 will exhibit greater cellular efficacy in acidic tumor microenvironments than in normal tissues, due to increased cell entry and retention, coupled with an inherent steep increase in STING occupancy rate dependent on MSA-2 concentration. The preferential activation of STING by MSA-2 in tumors may largely contribute to the observation of good in vivo anti-tumor activity and tolerance of this compound.
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FAQ
Q1. : Have you received my payment? How long will it take?
Generally, we can receive your payment the next day, and we will inform you as soon as we receive your payment.
After confirmation payment, we will send out package
Q2.：When will you sent out the goods after successful payment?
A: Normally the order will be delivery within 1-3 days after the order confirmed, except the customized products.
Q3.：What modes of transportation do you have to choose?
We cooperate with HKEMS, DHL, TNT, UPS, FEDEX, EMS, China Air Post ，sea transportation etc.
And with the SAFE SHIPPING in each country, you can receive the goods smoothly.It is fast and safe method.
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