N-acetyl selank amidate peptide

Xi'an Faithful BioTech Co., Ltd: Your Trusted N-acetyl selank amidate peptide powder Manufacturer & Supplier

N-acetyl selank amidate peptide is a synthetic, intellectually stimulating, and anti anxiety peptide, which is an improved version of the peptide Selank powder developed in Russia. The N-acetyl selank amidate powder provided by Xi'an Faithful BioTech Co., Ltd. inherits its stability，but also increases its potency, half-life, absorbability, and ease of crossing the blood-brain barrier. In addition, In animal research, the N-acetyl selank amidate peptide reagent we provide has significant effects in neuroprotection, antidepressant, stress resistance, and cognitive enhancement.Compared with Selank, it has better efficacy and fewer side effects in animal research, and its future prospects will be better. It is highly likely to replace Selank peptides in the future

N-acetyl selank amidate peptide powder Introduction

Selank peptide may exhibit immunomodulatory potential; However, in models of anxiety and cognitive decline, its potential for promoting intelligence is not very optimistic, especially in crossing different tissues and models (including the blood-brain barrier). Therefore, researchers added a Pro-Gly-Pro fragment at its C-terminus, which is the conventional N-acetyl Selank Peptide, a short synthetic heptapeptide structure. We know that the blood-brain barrier is a highly selective, semi permeable boundary that separates circulating blood from tissues and extracellular fluid in the central nervous system, and is believed to play a crucial role in regulating substance passage. Pro-Gly-Pro may enhance the permeability of the active molecule itself by potentially affecting the overall hydrophilicity or lipophilicity of the peptide, thereby increasing its affinity for the lipid rich environment of the blood-brain barrier. Research has shown that the Pro-Gly-Pro sequence of n-acetyl selank can interact with specific transport mechanisms or receptors of the blood-brain barrier, potentially triggering facilitation transport or receptor-mediated endocytosis. This process may allow Selank to bypass the tight connections that typically restrict the passage of large molecules. However, Pro-Gly-Pro fragments may also affect the tertiary structure of peptides, making them prone to premature collapse and loss of efficacy while facilitating crossing the blood-brain barrier. Although this phenomenon can be converted at sufficient doses, it invisibly increases its overall effectiveness. So, Our provided N-acetyl selank amidate peptide has a Pro-Gly-Pro fragment at the C-terminus and an acetyl group attached to the N-terminus amidate （Not N-terminus）. Adding an acetyl group to the N-terminus amidate of N-acetyl Selank amide may enhance peptide stability through several speculated mechanisms. Acetylation may also potentially protect peptides from rapid enzymatic degradation by exoneptidases, as it may make it difficult for these enzymes to access or recognize the N-terminus amidate. In addition, acetylation can induce changes in peptide structure, which may lead to a more stable conformation and thus resist denaturation.

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Why Choose Us? 

The selection of our company's N-Acetyl Selank is based on its excellent bioavailability and metabolic stability achieved through innovative acetylation modification process, combined with the purification process that strictly meets international standards (HPLC purity ≥99%), full batch third-party mass spectrometry verification and transparent and traceable analysis certificate. These characteristics together ensure the high reliability and experimental reproducibility of the data in the field of cognitive function research-and this ultimate pursuit of quality is the core driving force for our subsequent plans to develop other peptide products (such as Selank, Semax and their acetylated derivatives). We believe that the same rigorous synthesis technology and quality control system will provide continuous scientific guarantee for the peptide research matrix.if you need to purchase N-acetyl selank amidate peptide powder powder, please leave me a message. My email address is: sales8@faithfulbio.com

What are the inferences about the mechanism of N-acetyl selank amidate peptide powder?

Firstly, Selank may play a role by stimulating the γ -aminobutyric acid (GABA) receptor system. Researchers speculate that N-acetyl selank amidate with the same function can also enhance the ability to induce gene expression changes related to GABA receptors, transporters and ion channels. However, it should be noted that it may also regulate the function of GABA energy system in a way different from GABA-induced direct receptor activation.
Secondly, it may interact with the serotonin signal. Experiments in the mouse model with blocked serotonin synthesis show that N-acetyl selank amidate peptide may exert its potential to regulate the serotonin level in the case of impaired serotonin function. However, it is a mechanism to correct the disorder related to the decrease of serotonin function. Therefore, it is very likely that it can not only promote the enhancement of serotonin metabolic activity in brain regions related to regulating mood and anxiety, but also regulate serotonin levels in other regions, so that patients are in an abnormal state.
Thirdly, it may play a role by regulating enkephalin signal transduction. In the anxiety model, the level of tau(1/2) leuenkephalin may increase during the exposure of N-acetyl selank amidate powder, but more experiments are needed to explain this phenomenon.
Finally, it may potentially affect the expression of brain-derived neurotrophic factor (BDNF), especially increase the level of BDNF mRNA in the hippocampus of the central nervous system of mammals. This indicates that it has potential research significance in improving the reduction of neuroplasticity.
In addition, researchers are currently studying the potential role of the peptide in the inflammatory process through genome expression.

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Email: sales8@faithfulbio.com

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