PE 22-28 peptide powder

Xi'an Faithful BioTech Co., Ltd: Your Trusted PE 22-28 peptide powder Manufacturer & Supplier

PE-22-28 is a synthetic derivative of natural peptide spadin, which is derived from sorted protein. It can be used as an antagonist of TREK-1 receptor, which makes it play a key role in exploring the origin of depressive behavior and is a potential regulator of neurogenesis. According to the comparison of experimental results, the shortened analogues of Spadin peptide  (especially PE 22-28 peptide powder) provided by Xi'an Faithful BioTech Co., Ltd. seem to show better TREK-1 inhibitory effect than the original spadin. According to relevant clinical data, PE-22-28 powder has higher stability and can induce higher neurogenic stability, making it a promising candidate product in neurological research. In addition, the relationship between antidepressants and neurogenesis is also very important. PE-22-28 is excellent in this respect, because it seems to induce neurogenesis in just a few days, and the growth of new neurons indicates the potential possibility of relieving depressive symptoms.

PE 22-28 peptide powder Introduction

As mentioned above, the mechanism of action of PE-22-28 peptide mainly revolves around its role as a receptor antagonist of TREK-1(TWIK-related potassium channel). By binding and inhibiting TREK-1, it can regulate the potassium ion current in nerve cells, thus affecting the excitability of neurons and the release of neurotransmitters. This kind of inhibition is considered by the scientific community as the key to enhance the neurogenic response and may promote the growth of new neurons. At the same time, scientists continue to carry out extensive research to improve the bioavailability and stability of Spadin derivatives and analogues. It is these studies that show the seven amino acid structures of PE-22-28. According to its structural characteristics, researchers have developed many products with better performance than PE-22-28 by restructuring their natural counterparts, such as KKI 5 peptide, which has the potential to reduce the infiltration of breast cancer cells. Our company is also developing the potential function of PE 22-28 peptide powder, hoping to reveal all the effects and potential nervous system effects of PE 22-28 through various investigations and make its own contribution to the improvement and breakthrough of the nervous system.

Specifications

Why Choose Us? 

Choosing our company's PE 22-28 peptide powder means that you have chosen a strategic partner who is at the leading level in purity, reliability and technical support. The following are our core strengths:

1. Excellent quality and strict quality control
We adopt the international cGMP standard to ensure that each batch of PE 22-28 peptide powder has:

Ultra-high purity (≥99%): Strictly verified by HPLC and mass spectrometry, to minimize the interference of impurities and ensure the accuracy and repeatability of experimental results.

Accurate sequence and structure: It completely conforms to the target sequence (Glu-Glu-Ala-Glu-Asn-Leu-Ala), and the correctness of the secondary structure is confirmed by nuclear magnetic resonance (NMR) to ensure its biological activity.

Strict aseptic and pyrogen-free control: it meets the standards of Pharmaceutical-grade raw materials and is suitable for high-level research in vitro and in vivo.

2. Technical expertise and customization ability
As experts in the field of peptides, we not only provide products, but also provide solutions:

In-depth technical support: It can provide detailed physical and chemical data (MS, HPLC atlas), dissolution suggestions and experimental scheme reference to help you speed up the research and development process.

Flexible customization service: support different specifications, modifications (acetylation, amidation, etc.) and packaging requirements, and accurately match your scientific research or development goals.

3. Stable supply and compliance guarantee
Large-scale production: independent production line ensures batch consistency, supports stable supply from mg to kg, and eliminates the risk of out-of-stock.

The whole chain can be traced: the whole process from raw materials to finished products can be traced, and complete compliance documents (COA, MSDS) can be provided, which can easily meet the needs of audit and declaration.

We are committed to becoming your trusted peptide partner, not only providing the highest quality products, but also escorting your research with scientific depth and service response. You are welcome to contact our scientific team at any time. Our email address is: sales8@faithfulbio.com.

Effect demonstration of PE 22-28 peptide powder

1. Depression
Studies in mouse depression model have confirmed that PE-22-28 has a significant effect in relieving depression symptoms. It can relieve depressive symptoms in just a few days without adversely affecting other functions of TREK-1 channel regulation. In addition, it should be noted that the hippocampal volume of mice is decreasing, but the neurons are increasing, which is quite different from the traditional antidepressants that can enhance neurogenesis and possibly increase the hippocampal volume, thus fighting against depressive episodes. Scientists believe that PE-22-28 may be a new method to solve depression by developing nerves to offset the potential of hippocampal volume reduction, and may reveal the potential physiological pathway related to the disease.
2. Neurogenesis
In the research report of mice with brain tumor, PE-22-28 can enhance neurogenesis and synapse formation within a few days, increase the number of BrdU positive cells (used as markers of DNA replication) by about one time, and may increase the rate of synapse formation, but the tumor area has little effect. The report points out that it can enhance the mRNA expression and protein level of two synaptic markers (95 kDalton postsynaptic dense protein (PSD-95) and synaptic protein), and after a certain dose, it will lead to a rapid increase in the mRNA expression and protein level of brain-derived neurotrophic factor (BDNF) in hippocampus, which may be one of the reasons for its antidepressant effect.
3. Brain cell division
PE-22-28 is thought to affect brain cell division, but this speculation is only supported by related research papers. According to the summary of the research paper, it can bind to cAMP reactors and affect the protein CREB. Among them, CREB is a transcription factor that is crucial to neuronal plasticity, memory formation and spatial memory development, and is helpful to the rapid transcription division of nerve cells. But this study still needs more data support.
4. Brain injury
We know that hippocampus is an area in the brain that is often concerned in the study of depressive behavior, and it is also considered to play a vital role in the process of learning and memory. However, its excellent plasticity makes it vulnerable to various injuries, which are related to depression, anxiety and Alzheimer's disease. PE-22-28 can bypass the problem of enhancing the regeneration ability of hippocampus. This discovery continues to challenge the traditional concept and opens up a new way for the exploration of TREK-1 regulation. It also shows that PE-22-28 or similar TREK-1 antagonists may show better intelligence-promoting properties in the future.
5. Poststroke depression
Post-stroke depression (PSD) is a common complication of cerebral ischemia, which cannot be cured by conventional therapy. The experimental mouse model shows that the use of SSRI (selective serotonin reuptake inhibitor) and TREK-1 inhibitor (such as PE-22-28) may alleviate or reverse this up-regulation. However, because SSRI drugs are associated with a variety of unexpected side effects, this study needs to solve the problem of availability first.
6. Muscle function
Inhibition of TREK-1 seems to enhance muscle contractility, while activation of channels is thought to promote muscle relaxation. Although this function of TREK-1 channel is still in the early stage of exploration, its importance is steadily increasing. Exploring the contribution of PE-22-28 and other molecules to muscle contraction and relaxation is expected to open up new ways and help us understand the complexity of muscle physiology.

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Ready to elevate your peptide products with our premium PE 22-28 peptide powder ? Contact our expert team today to discuss your needs and discover how Xi'an Faithful BioTech can support your business growth.

Email: sales8@faithfulbio.com

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