CAS NO.: 158563-45-2
structural formula:C61H87N15O9S
English alias:Nonapeptide-1;Melitane;Melanostatine-5(nonpeptide-1);melanostatine;Melitan;Nonapeptide-1
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate:FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place;36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents." data-aw-url="https://www.faithfulbiochem.com/steroid-raw-powder/nonapeptide-1-powder/" title="Nonapeptide-1 Powder">
Melitan is a bionic peptide, which has a very good match with MC1 receptor on melanocytes, so it can be used as an antagonist of melanocyte stimulating hormone. According to the relevant market feedback, the Nonapeptide-1 powder provided by Xi'an Faithful BioTech Co., Ltd is safe, non-irritating and non-toxic, and it is a whitening and freckle-reducing raw material that must be added to top-grade cosmetics. At present, it can be used in many types of body care products, such as facial care products such as cleansing, cream, water cream, essence, BB cream, body milk, shower gel and so on.
Melanostatine-5, also known as Melitane, is a whitening nonapeptide containing nine amino acids, which is mainly used for whitening and brightening skin and removing spots. At the same time, nonapeptide -1 powder is a bionic peptide, which can competitively bind with MC1 receptor to prevent tyrosinase from being further activated to produce melanin. Therefore, this product is widely used in the production field of cosmetics industry. However, when the medicinal whitening nonapeptide -1 is used as a cosmetic raw material, the HPLC purity is required to be ≥ 99%. However, the crude nonapeptide -1 obtained by synthesis contains many impurities, and it can only be used as a cosmetic raw material after further purification. Xi'an Faithful BioTech Co., Ltd. knows the importance of product quality, so our company broke the traditional method of repeatedly purifying peptides by using reversed-phase high performance liquid chromatography, and used reversed-phase polymer column in combination with weak anion exchange column for desalination, which greatly improved the purification efficiency and saved the cost of mobile phase in the whole purification process. Moreover, the purification process not only properly solved the problem that it was difficult to completely separate impurities with different structures and chemical properties from crude peptides by a single column, but also used less solvents in the whole process. To provide the basis of experimental raw materials for the development of safe and gentle whitening cosmetics.
Item | Specifications | Results |
Description | White Crystalline Powder | White Powder |
Identification | Positive | Positive |
Assay(by HPLC) | 98.0~102.0% | 99.34% |
Absorbance(E1cm) | 465~495 | 482.5 |
Melting Point | 191~195°C | 193.5~195.0°C |
Loss On Drying | 0.5%max | 0.19% |
Specific Rotation | +288°~ +298° | +290.2° |
Residue On Ignition | 0.1%max | 0.03% |
Related Substances | Total:1.5%max | <1.3% |
| Single:0.5%max | <0.4% |
Residue Solvents | 0.2%max | 0.10% |
Heavy Metals | 20PPm max | <10PPm |
Conclusion: | Conform with enterprise specification . |
1: Price competitiveness and cost-effectiveness: We can provide high-quality products at prices lower than the market average through efficient supply chain management and location advantages, truly saving costs for our customers. For example, our company has long-term cooperation agreements with major pharmaceutical laboratories and chemical plants in China. We can not only provide our products at good prices, but also offer you reagents and bulk commercial grade raw materials at discounted prices.
2: Product innovation and quality assurance: Emphasis is placed on material selection and process optimization to ensure durability and user experience. Our product optimization is based on customer feedback and adaptation to new national standards. For new technologies and processes, we first use them on a small scale and then promote them on a large scale to ensure that customers can obtain products of different grades and processes.
3: The overall value of the solution: not only selling individual products, but also providing integrated solutions with better prices (such as puzzle series, enzyme reagent series, etc.), helping customers reduce operating costs and save transaction time.
4: Accuracy of demand matching and service support: The product matrix covers all aspects of production and life, with a repurchase rate far exceeding the industry average, ensuring long-lasting practicality; We also provide 24/7 customer service, rapid response mechanism, and long-term after-sales support.
5: Emotion and personalized value: Integrating environmental protection concepts and brand stories into products to establish emotional connections; Support customized services to enhance users' sense of belonging.
These advantages stem from the company's strong R&D team and resource integration capabilities, ensuring that products stand out in the market and create sustained value for users.If you are interested, please contact me via Email: sales8@faithfulbio.com.
We know that the primary source of melanin formation within human cells is ultraviolet radiation. When ultraviolet radiation strikes the skin, various chemical reactions occur within the skin to produce melanin. Most existing whitening ingredients inhibit melanin production by inhibiting tyrosinase activity. melanostatine, however, takes a different approach, inhibiting melanin production at the source. Experiments have shown that Melitan powder occupies extracellular binding sites on melanocytes long before tyrosinase is activated. By competitively blocking the access points for receptors and various signaling factors on melanocytes, it weakens melanocyte activity and reduces melanin production. Market feedback indicates that cosmetics formulated with Melanostatine-5(nonpeptide-1) powder gradually even out skin tone after 14 days of use. After one skin cycle (28 days), skin tone is noticeably brightened, resulting in a rosy, fairer complexion. Therefore, nonapeptide-1 is a widely used and common cosmetic ingredient.
However, it is important to note the storage of nonapeptide-1 raw materials. For short-term storage, we recommend storing in a cool, dark, dry, and clean place to ensure a shelf life of at least six months. For long-term storage, we recommend storing at -15°C to -20°C in a sealed, dark place. Theoretically, the shelf life of this product can be extended to 24 months. During storage, try to keep the bottle cap tightly sealed to prevent microbial contamination. Once opened, use it as soon as possible.
First, we will never evade problems and responsibilities, and seek an optimal solution through communication.
Second, If there is a real quality problem caused by us, we will send you free goods for replacement or refund.
Your satisfaction is very important to us. If there are any problems with the product you receive, please contact your account manager within 15 days of receiving of your order. Upon receipt and inspection, Faithful will issue a credit, refund or replacement.
Our shipping method requires no signature from your side upon delivery.
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