Peptide PNC-27
Other names:PNC27 peptide;
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Peptide PNC-27 Powder Manufacturer & Supplier
Peptide PNC-27 powder is an anti-cancer peptide with a unique mechanism of action that selectively targets the HDM-2 protein on the cancer cell membrane, inducing membrane lysis and achieving precise killing of tumor cells. The PNC-27 Peptide Xi'an Faithful BioTech Co., Ltd provide is a straight chain peptide composed of 32 amino acids, with a molecular formula of C ₁₈₈ C₁₈₈H₂₉₃N₅₃O₄₄S and a molecular weight of 4031.73. And it contains an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetration domain, which is designed to effectively penetrate the cell membrane and bind to the target
Peptide PNC-27 Powder Introduction
PNC27 Peptide powder is a novel synthetic peptide under research, and its mechanism of action is based on the significant difference in HDM-2 expression levels between cancer cells and normal cells. Therefore, researchers propose to focus on peptide materials containing HDM-2 binding domains. Among numerous research subjects, PNC27 has been described as a non-toxic protein molecule consisting of 32 amino acids, and it contains an HDM-2 binding domain. During the experimental process, it was found that it is also a protein that can easily interact with the tumor suppressor p53. Scientists assert that it may target a key pathway in cancer development. The 3D structure of the p53 residue of Peptide PNC-27 we provided directly overlaps with the same residue structure that binds to HDM-2, indicating that the peptide may target HDM-2 in the cell membrane. Further research feedback suggests that it can act by binding to specific receptors on cancer cells, leading to their death.
Specifications
Item | Specifications | Results |
PNC-27 | 99.0% | 99.15% |
Appearance | White powder | Conform |
Odor & Taste | Characteristics | Conform |
Particle Size | ≥90% through 80 mesh | Conform |
Loss on drying | ≤5.0% | 1.8% |
Total ash | ≤5.0% | 1.5% |
Heavy Metals | ≤5.0ppm | Conform |
Lead (Pb) | ≤3.0ppm | 1.07ppm |
Arsenic (As) | ≤3.0ppm | 1.79ppm |
Cadmium (Cd) | ≤1.0ppm | 0.36ppm |
Mercury (Hg) | ≤1.0ppm | 0.23ppm |
Residual solvents | ≤50 ppm only ethanol | <30ppm |
Total Plate Count | ≤1,000cfu/g | 260cfu/g |
Yeast & Mold | ≤100cfu/g | 10cfu/g |
E. Coli. | Negative | Negative |
Salmonella | Negative | Negative |
Staphylococcus | Negative | Negative |
| Conclusion： | Conform with enterprise specification （USP 41）. |
Why Choose Us?
In the highly competitive field of anticancer peptide research, choosing a reliable and efficient Peptide PNC-27 powder is the first step to success. We know that your research can't tolerate any compromise, so we provide you with an excellent choice beyond your peers.
1. Excellent purity and strict quality control.
The purity of PNC27 peptide provided by us is always stable at ≥98% (HPLC). Each batch of products is equipped with detailed quality control analysis certificates to ensure that the products you receive have unparalleled consistency and reliability between batches, and to ensure the accuracy and repeatability of your experimental data from the source.
2. Accurate sequence and verified biological activity
Our PNC27 sequence (PPlsqetfsdlwkllkkwkmrrnqfwvkvqrg) has been accurately verified by MALDI-TOF mass spectrometry to ensure that the structure is completely correct. More importantly, our products have been verified by in vitro functional activity, which can effectively induce the death of specific cancer cells through HDM-2 binding pathway, directly provide a reliable tool with expected biological activity for your research, and help you accelerate the scientific research process.
3. Excellent customer support and service
We not only provide products, but also are your research partners. We provide detailed technical information, including solubility, stability suggestions and references. Our expert team is ready to provide you with professional technical support and answer the difficult problems you encounter in the experimental design.
Provide a solid foundation for your breakthrough research. Contact us immediately for the latest data and quotation.
Our email address is：sales8@faithfulbio.com.
Tapplied research
In the study of acute myeloid leukemia, Peptide PNC-27 Powder has demonstrated in vivo anti leukemia activity. In vitro studies have shown that PNC-27 can induce cancer cell death and bind to HDM-2 bound to the cell membrane. The specific process of action includes:
1. Targeted recognition: PNC-27 selectively recognizes the highly expressed HDM-2 protein on the cancer cell membrane
2. Membrane pore formation: After binding with HDM-2, transmembrane channels are formed on the cell membrane
3. Cell lysis: causing ion imbalance and osmotic pressure collapse in cancer cells, ultimately leading to cell necrosis
4. Selective killing: Due to the low expression level of HDM-2 in normal cells, PNC-27 has little effect on normal cells
Although PNC-27 Peptide has shown good anti-tumor activity in various cancer models and encouraging preclinical research results, developing PNC-27 into an approved product still faces the following challenges:
1. Stability issue: Peptide drugs are easily degraded by proteases in vivo
2. Delivery efficiency: Need to optimize the route of administration and formulation technology
3. pharmacokinetics: need to improve its in vivo distribution and half-life
4. Large scale production: requires the establishment of stable and economical production processes
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FAQ
Q1.What is the difference between PNC-27 and other anti-cancer peptides?
The uniqueness of PNC-27 lies in its ability to target the HDM-2 protein in the cancer cell membrane, which enables it to selectively kill cancer cells while avoiding toxic effects on normal cells. Unlike traditional apoptosis inducers, PNC-27 works through the mechanism of membrane pore formation.
Q2. Is PNC-27 effective against apoptotic deficient cancer cells?
Yes, PNC-27 is still effective against apoptotic deficient cancer cells. Its mechanism of action does not depend on p53 activity, but directly induces membrane pore formation leading to cell necrosis, making it equally effective against cancer cells with apoptotic pathway defects.
Q3.What is the relationship between PNC-27 and p53 protein?
The design of PNC-27 is based on the peptide sequence of p53 protein and HDM-2 binding domain. The expression level of HDM-2 in cancer cells is much higher than that in normal cells. Based on this differential characteristic, researchers have developed PNC-27 on the basis of p53 protein. Q4.What is the selectivity of PNC-27?
PNC-27 has high selectivity and mainly acts on cancer cells without affecting normal cells. This is because HDM-2 has significant levels in the cell membranes of various cancer cells, but its expression levels are lower on the cell membranes of some untransformed cell lines. Researchers have found that when full-length HDM-2 is expressed in normal cells, these cells also become sensitive to PNC-27.
Q5.What is the purity requirement for PNC-27?
PNC-27 typically requires a purity of ≥ 99% and is detected by HPLC method. The purity specifications of products provided by different suppliers range from 90-99%, and can be customized according to research needs.
Q6.How to store PNC-27?
PNC-27 should be freeze-dried at -20 ℃ and stored away from light. The product is usually provided in the form of a white solid and needs to be sealed for storage to prevent degradation.
Contact us
As a novel anti-cancer peptide, PNC-27's unique targeting mechanism provides new ideas for precision cancer treatment. Although it is still in the research stage, its application prospects in the field of cancer treatment are worth looking forward to. If you hope to make progress in this area, please leave us a message via email:sales8@faithfulbio.com
