Spadin peptide

Xi'an Faithful BioTech Co., Ltd: Your Trusted Spadin peptide Manufacturer & Supplier

Xi'an Faithful BioTech Co., Ltd. sells high-purity Spadin peptide. Our company boasts a highly experienced team with an average of over 10 years of experience in peptide production research, enabling us to provide professional support in product development, production, and quality control. We also understand the storage requirements of Spadin peptide and can provide customers with accurate storage advice, such as the ability to store powdered Spadin for 2 years at -80℃ and 1 year at -20℃. During transportation, we also take appropriate measures to ensure that product quality is not affected.

Spadin peptide Introduction

Spadin peptide is a natural peptide derived from a propeptide released during the maturation of neurotensin receptor 3 (also known as sortilin). Spadin is a potent TREK-1 channel blocker, specifically binding to TREK-1 with an IC50 value of 10 nM. It modulates neuronal excitability by blocking TREK-1 channels, affecting potassium ion efflux from neuronal cell membranes, thereby altering the neuronal membrane potential. Spadin is also a potent antidepressant. It has been used in antidepressant research; being brain-permeable, it has demonstrated rapid onset and no adverse effects in mouse models of depression. Its antidepressant properties are associated with increased neurogenesis and synaptic formation in the brain.

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Why Choose Us?

1. High Product Quality: Our Spadin peptide boasts extremely high purity. This high purity ensures product stability and efficacy, better meeting research needs.

2. Professional Technical Support: We have a professional team that can provide clients with technical consultation regarding Spadin peptide, including its mechanism of action, application scenarios, and storage methods.

3. Diverse Product Forms: We can provide various packaging specifications to meet client needs, including 1mg, 10mg, 100mg, and 1000mg. Furthermore, the product is typically a white solid powder, facilitating storage and transportation, and exhibits excellent solubility in water (≥100mg/mL), making it convenient for clients to use.

4. Excellent Reputation: We enjoy a strong reputation in the industry, adhering to the corporate philosophy of "using quality as our ship, service as our sail, and serving scientific research." We have provided high-quality services and products to numerous researchers worldwide, earning the recognition and trust of our clients.

Application Areas

• Antidepressant Research: Spadin is an effective TREK-1 channel blocker that blocks TREK-1 channels, modulates neuronal excitability, enhances 5-HT neurotransmission in the dorsal raphe nucleus of mice, and induces CREB activation and neurogenesis in the hippocampus, thereby exerting an antidepressant effect. It can be used in the design and development of antidepressant products.

• Ischemic Stroke Treatment Research: Studies have shown that Spadin has potential efficacy in treating ischemic stroke, but its specific mechanisms of action and effects require further in-depth research.

• Post-Traumatic Stress Disorder (PTSD) Treatment Research: Spadin has also shown potential value in the treatment of PTSD, potentially providing new ideas and methods for its treatment, but this is currently still in the research stage.

• Basic Neuroscience Research: Because Spadin acts on TREK-1 channels, affecting the neurotransmitter system and neuroplasticity, it can be used for basic neuroscience research, such as studying the function of TREK-1 channels and the mechanisms by which the neurotransmitter system and neuroplasticity play a role in physiological and pathological processes.

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FAQ

Q1: What is a Spadin peptide used for?

A1: Spadin is brain penetrant, and exhibits antidepressant effects in mouse models of depression with a rapid onset of action and an absence of adverse effects. The antidepressant properties are associated with increased neurogenesis and synaptogenesis in the brain.

Q2: How does the antidepressant effect of Spadin peptide work?

A2: Spadin peptide increases neuronal membrane potential by blocking the TREK-1 channel, activating the MAPK and PI3K signaling pathways. The PI3K signaling pathway is involved in its protective effect against asteroidin-induced apoptosis. Simultaneously, spadin enhances the mRNA expression and protein levels of two synaptic markers, PSD-95 and synaptoprotein, and also leads to a rapid increase in the mRNA expression and protein levels of brain-derived neurotrophic factor (BDNF) in the hippocampus, thus exerting its antidepressant effect.

Q3: What are the similarities and differences in the effects of Spadin peptide in vivo and in vitro?

A3: The similarity lies in the fact that spadin peptide enhances the expression of synaptic-related proteins, such as PSD-95 and synaptoprotein, in both in vivo and in vitro experiments. The difference is that in vivo, spadin leads to a rapid increase in the mRNA expression and protein levels of BDNF in the hippocampus, while in vitro, the main changes are at the molecular level, such as activation of the MAPK and PI3K signaling pathways.

Contact Us

Essential for antidepressant and neuroscience research – Spadin peptide. Quality guaranteed, first come, first served, fast procurement! Please contact my email sales9@faithfulbio.com.

Email: sales9@faithfulbio.com

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