Calcium Ketoglutarate Monohydrate

Product Name:Calcium 2-oxoglutarate
CAS.NO:71686-01-6
structural formula:C5H8CaO5
EINECS.no:275-843-2
Other names:Calcium Ketoglutarate Monohydrate;Calcium α-ketoglutarate;Calcium 2-oxoglutarate;α-Ketoglutaric acid calcium salt;2-Oxopentanedioic acid calcium salt;Calcium 2-oxopentanedioate;Ca-ketoglutarate
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.

Product Description

Xi'an Faithful BioTech Co., Ltd: Your Trusted Calcium Ketoglutarate Monohydrate Manufacturer & Supplier

Calcium Ketoglutarate Monohydrate is an important biomolecule in nature, serving as a crucial intermediate in the Krebs cycle, nitrogen transport, and molecular oxidation. It is involved in the metabolism of various substances such as amino acids, sugars, proteins, and fats in the body. The Calcium 2-oxoglutarate provided by Xi'an Faithful BioTech Co., Ltd Company is not only an important salt form, but also widely used in fields such as feed, health food, and fine chemicals due to its good solubility and easy formation of solids for purification.

Calcium Ketoglutarate Monohydrate Introduction

Calcium Ketoglutarate Monohydrate, commonly abbreviated as Ca AKG, is a salt formed by the combination of mineral calcium and 2-ketoglutarate.
Calcium: an essential mineral that is crucial for bone health, muscle function, nerve signal transmission, and more.
2-Ketoglutaric acid: a key molecule in the Krebs cycle. It is a precursor of various amino acids and plays a role in cellular metabolism and signal transduction.
By combining the two, Ca AKG provides both calcium and AKG in a compound form. Research has shown that it has the following biological activities and mechanisms of action:
1. Main physiological functions
Calcium 2-oxoglutarate has multiple physiological functions in the body. As a key intermediate in the Krebs cycle, it participates in cellular energy metabolism and is an important link in the generation of ATP and GTP. In addition, it also serves as the main carbon backbone for nitrogen assimilation reactions, participating in the synthesis of amino acids and nucleotides.
2. Enzyme inhibition
This compound is a reversible inhibitor of tyrosinase with an IC50 value of 15 mM. This characteristic makes it of significant application value in related biochemical research.
3. Other physiological functions
In vitro studies have shown that Calcium 2-oxoglutarate also has neuroprotective effects in reducing ammonia levels formed in the lungs, promoting ammonia detoxification, preventing lipid peroxidation, and resisting cyanide poisoning.

Specifications

Item	Specifications	Results
Appearance	White to off white crystal fine powder	Complies
Odor &Tasted	Characteristic	Complies
Assay(%)	≥98.0	98.65
Loss on Drying(%)	≤0.5	0.14
Residue on lgnition(%)	≤0.1	0.02
Particle size(%)	100%through 80 mesh sieves	99%
Heavy Metal(ppm)	≤10.0	1.38
Pb(ppm)	≤1.0	Negative
As(ppm)	≤1.0	Negative
Hg(ppm)	≤0.1	Negative
Cd(ppm)	≤1.0	0.8
Total Plate Count	≤1000cfu/g	10cfu/g
Total Yeast & Mold	≤100cfu/g	10cfu/g
E.Coli	Negative	Negative
Salmonella	Negative	Negative
Conclusion	Conform with enterprise specification （USP 41）.

Why Choose Us?

1.By choosing our Calcium Ketoglutarate Monohydrate, you will receive excellent raw material quality and professional technical support. We provide high specification products with a purity of ≥ 98%, strictly following the ISO certified production process. Each batch is equipped with complete third-party testing reports (COA), HPLC, and mass spectrometry analysis data to ensure accurate and stable composition, meeting the strict requirements of pharmaceutical research and development and advanced nutritional supplement production.
2.We have significant advantages in supply chain assurance and customized services. Relying on standardized production bases, we can stably supply different order requirements from gram level to kilogram level, supporting personalized granularity, purity, and packaging customization. At the same time, we provide professional technical consultation and regulatory document assistance to help you accelerate the product development and registration process.
3.We are committed to becoming your reliable long-term partner. We can provide competitive pricing strategies and efficient logistics support for sample validation, bulk procurement, and joint research and development needs. If you are looking for a Calcium α-ketoglutarate supplier with stable quality, reliable supply, and professional service, please contact us immediately for free samples and detailed information.If you are interested, please contact me via email:sales8@faithfulbio.com.

What is its anti-aging mechanism?

The anti-aging mechanism of Calcium Ketoglutarate Monohydrate is complex and not fully elucidated, but it is believed to involve the following aspects:
Simulated dietary restriction: Ca-AKG may activate biochemical pathways similar to calorie restriction, which is a known intervention for extending lifespan.
Reduce cellular aging: It may help eliminate "aging cells", which are old damaged cells that accumulate and secrete inflammatory substances with age.
Epigenetic regulation: AKG is a cofactor of enzymes involved in DNA demethylation, which can affect gene expression and potentially reverse some age-related epigenetic changes.
Stem cell function: It may help maintain the health and regenerative ability of stem cells.