Fasudil hydrochloride API
Synonym: Fasudil Monohydrochloride;HA-1077;HA-1077 DIHYDROCHLORIDE;FASUDEL
CAS NO.: 105628-07-7
EINECS NO.: 805-833-0
Molecular Formula: C14H18ClN3O2S
Purity & Grade: 99%; Medicine grade
Character: White powder
Free sample: Available
Stock: In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 10g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-10 days
Store & Shelf life: Cool & dry place; 36 months
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted Fasudil hydrochloride API Manufacturer & Supplier
Xi'an Faithful BioTech Co., Ltd. sells high-quality Fasudil hydrochloride API. Our company's core strengths lie in four key areas: quality, technology, supply, and compliance. Our products boast a purity exceeding 99%, with some patented processes achieving up to 99.94% purity. Impurities are below 0.1%, fully complying with pharmacopoeia standards. Furthermore, leveraging our independently developed synthetic processes, we eliminate the need for expensive intermediates, achieving cost optimization and environmental friendliness, making them suitable for industrial mass production. Ample stock allows for flexible repackaging, with same-day shipping possible. Our global logistics network ensures efficient delivery.
Fasudil hydrochloride API Introduction
Fasudil hydrochloride API is an isoquinoline sulfonamide derivative and a novel calcium channel blocker. It not only has a strong antispasmodic effect on cerebral vasospasm following subarachnoid hemorrhage, but also provides some protection against ischemic brain tissue. Therefore, Fasudil hydrochloride has become the first-line product for improving and preventing cerebral vasospasm and the resulting cerebral ischemia symptoms after subarachnoid hemorrhage surgery.
COA
| Test items | Specifications | Results |
| Appearance | White crystalline powder | Complies |
| Ident ification (HPLCUVIR) | HPLC RT2.8±0.3min | 7.48min |
| UV Spectrum λ<sub>max</sub>b>305,290,220 nm(MeOH) | 220 nm | |
| IR Spectrum Matches reference spectrum | Complies | |
| Assay(HPLC) | 98.0%-102.0% | 99.9% |
| Water Content(KF) | ≤0.5% | 0.3% |
| PH | 4.0-6.0 | 5.0 |
| Related Substances | Des-hydroxy Fasudil:≤0.15% | 0.10% |
| Fasudil Sulfoxide:≤0.10% | 0.05% | |
| Any individual impurity:≤0.10% | 0.05% | |
| Total impurities:≤0.5% | 0.3% | |
| Heavy Metals | 20 ppm | 10ppm |
| Microbial Limits | Total Aerobic Count:<1000 CFU/g | <100 CFU/g |
| Yeast &Mold≤100 CFU/g | ≤10 CFU/g | |
| E.coliNegative | Negative | |
| Salmonella Negative | Negative | |
| Conclusion | Conform with enterprise specification | |
Why Choose Us?
Strict Quality Control: Our products undergo rigorous quality control testing, including qualitative and functional testing, to ensure that every batch meets high-quality standards.
High Purity: As a non-specific RhoA/ROCK inhibitor, the purity of Fasudil hydrochloride is crucial for scientific research. We ensure the supply of high-purity active ingredients.
Professional Support: We are committed to providing our clients with the necessary support and information to ensure you can use the product correctly, whether for scientific research or other compliant applications.
Stable Supply: We have the capacity for mass production or to provide a stable supply to meet your needs.
Application Areas
Cerebral vasospasm and cerebral ischemia: These are the main indications for Fasudil hydrochloride. It is widely used to prevent and treat cerebral vasospasm following subarachnoid hemorrhage (SAH) and to improve accompanying cerebral ischemia symptoms, significantly reducing morbidity and mortality.
Pulmonary hypertension: Studies have shown that Fasudil hydrochloride has potential in treating pulmonary hypertension by improving blood flow through relaxation of pulmonary artery smooth muscle.
Neuronal regeneration: Research has found that Fasudil hydrochloride can promote the survival of neural stem cells, axonal regeneration, and the directed differentiation of bone marrow mesenchymal cells into neurons.
Fibrotic diseases and cancer: By inhibiting the effects of the ROCK pathway on the cytoskeleton and cell motility, Fasudil hydrochloride has potential applications in treating fibrotic diseases and cancer metastases characterized by excessive cell proliferation and migration.
Ophthalmic diseases: In the field of ophthalmology, Fasudil hydrochloride is also being explored for the treatment of glaucoma and diabetic retinopathy.
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FAQ
Q1: What is Fasudil hydrochloride API?
A1: Fasudil hydrochloride is a potent Rho kinase (ROCK) inhibitor and vasodilator. It relaxes vascular smooth muscle, improves blood flow, and has neuroprotective effects by inhibiting the activity of the ROCK enzyme.
Q2: What are the common side effects of Fasudil hydrochloride API?
A2: Common side effects are usually manageable and include:
Headache and dizziness.
Low blood pressure, which may cause dizziness or fainting.
Gastrointestinal discomfort such as nausea and vomiting.
Occasionally, palpitations and itchy skin may occur.
Q3: Can Fasudil hydrochloride API improve cognitive function?
A3: In animal models, Fasudil hydrochloride has been shown to improve cognitive function, reduce hippocampal neuronal loss, and decrease inflammatory markers. Currently, it is being explored as a potential product for early-stage neurodegenerative diseases such as Alzheimer's disease, and related trials are underway.
Contact Us
High-purity Fasudil hydrochloride API, in stock and ready to ship! 99%+ purity, meets pharmacopoeia standards, ample stock available, and ultra-fast global logistics delivery. Contact us now to secure your premium supply and enjoy exclusive pricing and technical support! Please contact my email sales9@faithfulbio.com.
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