6 diazo 5 oxo l norleucine powder
CAS. NO:157-03-9
MF.no:C6H9N3O3
EINECS:251-228-4
Other names:6-DIAZO-5-OXO-L-2-AMINOHEXANOIC ACID;6-DIAZO-5-OXO-L-NORLEUCINE;6-DIAZO-5-OXO-NORLEUCINE;L-DON;6-diazo-5-oxo,l-norleucin;6-diazo-5-oxo-l-norleucin;diazo-oxo-norleucine;DON
Test Method:HPLC/UV/GC-MS
MOQ & Package: 10g,100g,1kg,5kg,10kg,25kg etc
Customer's rights and interests:Over 10kg, you can enjoy the service of giving away free samples.
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea,multimodal transport etc
Store & Shelf life; Cool & dry place; 36 months
Company advantages: there are self-built overseas warehouses and third-party overseas warehouses on all continents.
- Product Description
Xi'an Faithful BioTech Co., Ltd: Your Trusted 6 diazo 5 oxo l norleucine powder Manufacturer & Supplier
6 diazo 5 oxo l norleucine powder is a naturally occurring glutamine analogue and a powerful inhibitor of many enzymes that utilize glutamine. It was first isolated from Streptomyces in 1950s. Its main mechanism is to destroy cell metabolism by competitively inhibiting enzymes involved in nucleotide and amino acid biosynthesis. DON provided by Xi'an Faithful BioTech Co., Ltd can be used for in vitro (cell) and in vivo (animal model) research, and its main research fields include:
1. Cancer Biology: As a classic cytotoxic Pharmaceutical raw materials, it is used to study the metabolic pathway of tumors. At present, people's interest in using DON and its prodrugs to target cancer metabolism is rising again.
2. Immunology: used to study the role of glutamine metabolism in the activation and function of immune cells (such as T cells).
3. Cell metabolism: used to explore the importance of glutamine-dependent pathway in various cellular processes.
4. Agricultural research: Historically, L-DON powder has been studied as an antibiotic and an antiparasitic Pharmaceutical raw materials.
6 diazo 5 oxo l norleucine powder Introduction
6 diazo 5 oxo l norleucine powder is a glutamine antagonist that irreversibly inhibits the catabolism of glutamine. Research has shown that the chemical structure of L-DON is similar to glutamine, and it can block key cellular processes such as nucleotide and protein synthesis, as well as energy production, by acting on the active site of glutaminase. However, it should be noted that 6-DIAZO-5-OXO-L-NORLEUCINE itself is not an approved pharmaceutical ingredient. Due to its extreme systemic toxicity, its clinical application was limited in the 1950s and 1960s. However, research on DON precursor Pharmaceutical raw materials is still ongoing. According to the latest literature, scientists are developing the inactive form of L-DON, which converts prodrugs into active Pharmaceutical raw materials in vivo, with the aim of specifically targeting tumor sites with DON. Furthermore, it maximizes the anti-cancer effect while minimizing systemic toxicity. Currently in the clinical trial stage, it is highly likely to become a star product in cancer treatment in the future.
Specifications
Item | Specifications | Results |
Appearance | Light yellow crystal.(Easily deliquescent) | Conform |
Identification | The chemical reaction is consistent with the standard sample | Conform |
Melting point | 143˚ C | 145.82˚ C |
Heavy metals | <10ppm | Not detected |
Iron | <10ppm | Not detected |
Microbiological test | Refer to the regulations of USP on microorganism of this product. | Conform |
Assay | ≥98.8% | 98.9% |
| Conclusion： | Conform with enterprise specification （USP 41）. |
Why Choose Us?
When selecting a compound like 6-Diazo-5-oxo-L-norleucine powder, which possesses extremely high activity and potential risks, the reliability of the supplier directly impacts the success of your research, the credibility of your data, and, most critically, the safety of your personnel and laboratory. We deeply understand this responsibility and, with this at our core, provide you with irreplaceable value.
I. Uncompromising Quality and Purity – The Cornerstone of Your Research Data
For compounds like DON that function by inhibiting key metabolic pathways, even trace impurities can lead to significant deviations in experimental results, or even erroneous conclusions.
Verified High Purity: Every batch of DON powder we provide comes with an authoritative analytical certificate issued by an independent third-party laboratory. We guarantee a purity consistently ≥98% (based on CoA), and structural confirmation is achieved through HPLC, NMR, and mass spectrometry, ensuring you receive a target compound with a clearly defined composition and correct structure.
Strict Quality Control: From raw materials to finished products, we implement rigorous quality control procedures to ensure batch-to-batch consistency, guaranteeing high reproducibility of your experimental results.
II. Superior Safety and Compliance – Your Guardian of Laboratory Safety
We understand that the toxicity of DON necessitates absolute safety at every stage of transportation, storage, and handling.
Professional Packaging and Transportation: We use quadruple-sealed, impact-resistant professional containers and strictly adhere to the transportation regulations for hazardous chemicals. For international orders, we provide complete compliance documentation to ensure smooth customs clearance and safe delivery.
Comprehensive Safety Documentation: You will receive a comprehensive, GHS-compliant Safety Data Sheet (SDS) containing the latest hazard information, personal protective equipment, emergency response, and waste disposal guidelines. This document serves as the authoritative basis for your laboratory safety assessments and training.
III. Professional Technical Support and In-Depth Insight – A Partner Beyond a Supplier
We are not just a product provider, but a partner on your scientific journey.
In-Depth Expertise: Our technical support team consists of scientists with backgrounds in pharmacology or chemical biology. They possess a deep understanding of DON's mechanism of action as a glutamine antagonist, its research applications in cancer metabolism and immunology, and related in vivo and in vitro experimental models.
Application Support: We can provide you with solubility and stability advice, as well as relevant references, to help you optimize your experimental protocols.
IV. Reliable Supply Chain and Customer Service – Ensuring Your Research Never Stops
Stable and Reliable Supply: We have our own stable supply chain, ensuring a long-term, stable supply of DON, preventing your important research projects from being interrupted due to shortages of key reagents.
Efficient and Transparent Service: From inquiry and order placement to logistics tracking, we provide efficient and transparent service. We promise to provide a substantial response to your technical or order inquiries within 24 hours.
If you are interested in our 6 diazo 5 oxo l norleucine powder, please leave us a message via email：sales8@faithfulbio.com.
Bioactivity
1: Anti-tumor activity
DON showed good anti-cancer activity, especially in the treatment of pancreatic cancer. This compound can reduce the self-renewal potential and metastatic ability of tumor cells, making pancreatic tumors sensitive to PD1 Pharmaceutical raw materials, leading to tumor regression and prolonged survival.
2: Other biological activities
Antibacterial activity: has inhibitory effects on various bacteria
Antiviral activity: It has antiviral effects on parainfluenza virus type 2 and other viruses
Pain relieving effect: clinical research progress with certain pain relieving characteristics
DON powder has been promoted to Phase II clinical research and has shown good efficacy in early clinical studies. Among the 47 patients who received DON treatment for 2 weeks or longer, 31 (66%) showed stable or resolved condition. However, due to the narrow treatment window and severe gastrointestinal toxic side effects, its clinical development is currently incomplete.
Quality Control:
R&D Results:
Packaging and Transportation:
After-Sales Service:
Qualification Certification:
Transaction Feedback:
Exhibition:
FAQ
Q1: What are the main hazards of DON? What strict safety precautions need to be taken?
Core warning: 6-Diazo-5-oxo-L-norleucine (DON) is a highly toxic and potentially carcinogenic compound, and improper operation will bring serious health risks. All operators must receive professional training and strictly abide by the following safety regulations.
1. Main harmfulness
Toxic: DON is extremely toxic, whether through inhalation, skin contact or ingestion. It mainly acts on rapidly dividing cells, so it will cause serious damage to digestive tract mucosa, bone marrow and other tissues.
Targeted toxicity: it may cause serious gastrointestinal toxicity, bone marrow suppression (affecting hematopoietic function) and liver and renal function damage.
2. Key safety precautions
Personal protective equipment (PPE): Proper PPE must be worn during operation, including but not limited to:
Nitrile or similar protective gloves
Chemical protective clothing
Goggles or face shields
Engineering control (core requirements):
Powder operation: it must be carried out in a well-ventilated fume hood to prevent the risk of dust generation and inhalation.
Solution operation: It is strongly recommended to operate in a biosafety cabinet.
It is absolutely forbidden to operate DON powder or high concentration solution on an open experimental platform.
Cleaning and disinfection: After the operation, the workbench, equipment and all contact surfaces must be thoroughly cleaned and disinfected with appropriate disinfectant immediately.
Q2: How to correctly store and handle DON powder?
Storage conditions:
DON powder should be placed in the original container and stored in a cool, dry, well-ventilated and locked special chemical cabinet.
In order to maintain long-term stability, it is recommended to store it in a sealed, dark and dry place at-20 C or lower.
Solution preparation:
DON is usually soluble in water or neutral buffer. Because its diazo group is sensitive to light and heat, the prepared solution should be prepared now and away from light.
Waste disposal:
All materials that have come into contact with DON (such as gloves, gun heads, containers, etc.) must be collected as high-risk chemical waste.
Waste disposal must strictly abide by the regulations of your organization and the environmental protection regulations of local governments, and it is strictly forbidden to throw it away at will.
Q3: What key documents should be obtained when purchasing DON products?
In order to ensure product quality and safe operation, reputable suppliers must provide the following documents with the goods:
Certificate of Analysis (CoA): This certificate should indicate the purity of the product (usually ≥95%-98%), identification data (such as NMR, MS spectrum, etc.) and unique batch number to ensure that the products you receive are consistent with the quality inspection report.
Safety Data Sheet (SDS): This is a vital document, which lists the product's hazards, physical data, first aid measures, fire protection measures and emergency treatment of leakage in detail. Before operating DON, all relevant personnel must read carefully and fully understand the contents in SDS.
Contact us
Our DON product has been used by customers to publish 9 scientific papers, demonstrating its wide application value and reliability in the field of scientific research.
By choosing our 6-DIAZO-5-OXO-L-NORLEUCINE, you not only receive high-quality products, but also professional technical support and reliable service guarantee. We are committed to providing the highest quality solutions for your scientific research work. If you have any needs in this regard, please contact us via email:sales8@faithfulbio.com.
