GC376 sodium

Xi'an Faithful BioTech Co., Ltd: Your Trusted GC376 sodium powder Manufacturer & Supplier

GC376 belongs to 3C protease inhibitor, which is mainly used for the diagnosis of cats. GC376 sodium provided by Xi'an Faithful BioTech Co., Ltd. not only has a good inhibitory effect on feline infectious peritonitis virus (FIPV), but also can effectively inhibit Covid-19 in Vero cells by targeting Mpro, just like Boceprevir. Combining GC376 with Remdesivir can produce cumulative disinfection effect.

GC376 sodium powder Introduction

API GC376 sodium powder is a 3C like protease (3CLpro) inhibitor with broad-spectrum antiviral activity, initially used to treat feline infectious peritonitis (FIP). Subsequent studies have found that it also has inhibitory potential against various coronaviruses, including SARS-CoV-2. Structural analysis shows that the main mechanism of inhibition is the binding of the two inhibitors to the catalytic activity of the SARS-CoV-2 protease Mpro. Currently, most scientists indicate that this discovery provides key information for optimizing and designing more effective inhibitors against SARS-CoV-2 virus in the future. In addition, recent studies have shown that GC376, as a covalent inhibitor, can specifically bind to the active site cysteine residues (such as Cys145) of virus 3CLpro (main protease), thereby inhibiting the necessary polyprotein processing for virus replication and effectively preventing virus replication.

Specifications

Why Choose Us? 

In the fierce competition for antiviral drug development, choosing a reliable research partner is crucial. When your research focuses on GC376 sodium, a key 3CL protease inhibitor, choosing us means you will gain value beyond the product itself.

Reason 1: Excellent quality lays the foundation for research
We are well aware that the repeatability and accuracy of research begin with the purity and stability of the raw materials. The GC376 we provide adopts strict production processes and quality control standards to ensure that each batch has high purity (≥ 98%) and excellent stability. This means that your research data is more reliable, the experimental process is smoother, and it lays a solid foundation for your scientific discoveries.

Reason 2: Complete product ecosystem, empowering scientific research exploration
We not only offer GC376. We are committed to building a complete ecosystem of antiviral research products. When your research progresses from target validation (GC376) to preclinical studies, you don't need to look for new suppliers. Our star product GS-441524 (precursor of remdesivir) can be used as an extension or comparison of your research scheme to help you evaluate the efficacy more comprehensively. In addition, we also offer a variety of antiviral compounds, including EIDD-2801 (Molnupiravir analog), allowing you to conduct synergistic research on multiple targets and mechanisms on one platform, greatly improving research efficiency.

Reason 3: Professional support, working together to overcome difficulties
By choosing us, you will not only receive the product, but also a professional support team. We have a deep understanding of the mechanism of action and application scenarios of GC376 and related compounds, which can provide you with timely technical consultation and literature support to help you solve the challenges encountered in your research.

Take immediate action and initiate efficient collaboration

We believe that excellent scientific research results come from a focus on every detail. From the core GC376 to the cutting-edge GS-441524, we are willing to become your most trusted research partner with high-quality products and professional services.
Welcome to contact us for detailed product catalogs and technical information. ​​
Email: sales8@faithfulbio.com

What is the difference between GC376 and GS-441524?

GC376 and GS-441524 are two key drugs for treating feline infectious peritonitis (FIP), but their clinical trial data do show significant differences in cure rates, recurrence rates, and targeted disease types. After multiple experiments and comparisons, our company has come to the following conclusions:
1: Clinical differences from the perspective of mechanism of action
The difference in clinical data between the two is fundamentally due to their different mechanisms of antiviral action:
GC376 sodium, as a protease inhibitor, mainly exerts its effect by inhibiting the 3CL protease activity required for virus protein cleavage in the late stage of virus replication.
GS-441524 is a nucleoside analogue that mimics RNA synthesis by incorporating viral RNA strands, leading to premature termination of viral genetic material replication and inhibiting virus replication at an earlier stage.
2: How can we make the right choices in clinical practice?
Based on the above data, the following trends have emerged in clinical treatment selection:
A.GS-441524 has become mainstream: due to its higher remission rate, lower recurrence rate, efficacy in treating neuropathic FIP, and more convenient dosing frequency, GS-441524 has been regarded as the preferred drug for treating FIP, and therefore is more widely used in practical applications.

B.The potential of combination therapy: Studies have shown that combining GC376 (representing the 3CL protease inhibitor route) with GS-441524 (representing the RdRp inhibitor route) can increase the remission rate to 93.5% and achieve a recurrence rate of 0, providing a new approach for treating severe cases

C.GC376 does not currently support standalone use: Due to the need for more experimental data to support the safety of this product, it is currently only being used in the experimental phase.

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Contact us

If you have any questions about the scientific applications of GC376 sodium、 Boceprevir、Remdesivir or GS-441524, or have new procurement plans, or need customized professional product information, please contact us immediately. Our expert team is always ready to provide support and work together to drive your research project towards success.

Our email address is:sales8@faithfulbio.com​​​​​​​