Synonym:ARA-290(Cibinetide);ARA290, >98%;ARA290,Cibinetide, >98%;ARA290;WZTIQQBMSJTRBR-MUZUOSMHSA-N;ara290/Poziotinib
CAS NO.:1208243-50-8
EINECS NO.:200-001-8
Molecular Formula:C51H84N16O21
Purity & Grade: 99%; Medicine grade
Character:White Powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months" data-aw-url="https://www.faithfulbiochem.com/steroid-raw-powder/peptides-ara-290/" title="Peptides ARA-290">
Xi'an Faithful BioTech Co., Ltd. sells Peptides ARA-290. In the highly competitive chemical industry, Xi'an Faithful BioTech Co., Ltd. Stand out, with significant advantages in multiple dimensions, occupy a solid position in the market, and continuously drive the development of the industry. Xi'an Faithful BioTech Co., Ltd. It has gathered a professional R&D team composed of senior chemical experts, doctors and experienced engineers. The team members have diverse professional backgrounds, covering multiple fields such as organic chemistry, inorganic chemistry and materials science, providing a solid talent guarantee for technological innovation.
Peptides ARA-290 (also known as Cibinetide) is a synthetic peptide drug that acts as an agonist for the innate repair receptor (IRR), which is involved in anti-inflammatory and tissue-protective processes. Cibinetide has shown promise in treating neuropathic pain (e.g., from diabetes or sarcoidosis), promoting wound healing, protecting nerve fibers, and potentially helping with diabetic retinopathy. ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response.
ltems | Specification | Results |
Appearance | White or almost white fluffy powder | Conform |
Solubility | Soluble in water | Conform |
Water Content (Karl Fischer) | ≤8.0% | 4.60% |
Sodium ion | ≤5.0% | 1.57% |
Acetic Acid (By HPLC) | ≤5.0% | 0.16% |
Trifluoroacetic Acid | ≤0.5% | Not Detected |
Peptide Purity (By HPLC) | ≥98.0% | 99.79% |
Related Substance (By HPLC) | Total Impurities(%)≤2.0% | 0.21% |
Largest Single Impurity(%)≤1.0% | 0.05% | |
Bacterial Endotoxins | ≤10 EU/mg | Conform |
Assay | ≥85.0% | 92.12% |
Conclusion | Conform with enterprise specification |
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Neurological diseases: It can be used to treat sarcoidosis neuropathy. Relevant clinical trials have shown that it can increase the area of corneal nerve fibers and the length of nerve fibers within the epidermis of the skin, reduce the intensity of pain in patients, and improve functional activities. In addition, it also has potential therapeutic effects on other neuropathic pains such as diabetic peripheral neuropathy, and is expected to relieve symptoms by repairing damaged nerve fibers and inhibiting pain signal transmission.
Diabetes-related conditions: It can be applied in the field of islet transplantation. During the process of islet transplantation, it can alleviate local inflammatory responses in the liver, delay the occurrence of allogeneic rejection, increase the survival rate of islet grafts, and improve blood sugar control. At the same time, for patients with type 2 diabetes, it can also improve the apoptosis rate of pancreatic β cells and enhance insulin secretion capacity.
A1: ARA 290 can Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes - PMC.
A2: ARA 290 is an 11-amino acid, linear peptide, with a molecular weight of 1257 Daltons. The amino acid sequence is Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyr represents pyroglutamic acid).
A3: Administration of Peptides ARA-290 reduces cell and tissue inflammation, mitigates structural and functional changes within the cardiovascular system leading to amelioration of frailty and preserved healthspan.
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