Mu conotoxin: How can anti-aging technology gifted by the ocean rewrite the password for youthful skin?

1.What is Mu conotoxin? Unveiling the Mysterious Veil of Marine Peptides

Mu conotoxin is a type of peptide compound extracted from the venom of Conus consols. Its core member CnIIIC consists of 22 amino acid residues and has a tricyclic disulfide bond structure. Its molecular formula is C ₉ ₂ H ₁ ③₉ N ③₅ O ₂₈ S ₆, with a molecular weight of 2375.70 Da and a density of 1.71 ± 0.1g/cm ³ [[1] [5] [7]]. As an innovative cosmetic ingredient included in China, its unique molecular structure enables it to accurately target biological channels, with analgesic, anesthetic, and muscle relaxation activities. In recent years, it has emerged in the field of anti-aging skincare.

2.Why has Mu conotoxin become a new favorite in anti-aging? Full analysis of core advantages

2.1Mechanism of action: precise blockade, dynamic wrinkle resistance

Mu conotoxin reduces neuronal excitability and excessive acetylcholine release by inhibiting voltage-gated sodium ion channels (NaV1.4), thereby relaxing muscles and fading dynamic lines. Clinical trials have shown that a formula containing 0.01% Mu conotoxin can reduce crow's feet area by 18.3% (p<0.05) within 28 days, with an effect similar to botulinum toxin type A but milder.

2.2Physical and chemical properties: stable and efficient, suitable for multiple dosage forms

3.The biosynthetic pathway of Mu conotoxin

It was first isolated from the venom of marine gastropod mollusk Conidea, targeting multiple voltage sensitive sodium channels, mainly blocking Nav1.4 channels, with high selectivity and minimal side effects. Its highly folded peptide structure has the characteristics of strong penetration and high stability, targeting muscles to achieve a relaxing effect, quickly improving and fading dynamic lines, bringing a safe, natural and non stiff rejuvenation effect.

Patent CN110698553A provides a method for preparing conotoxin anti wrinkle peptide using solid-phase synthesis. First, amino acids are sequentially coupled from the C-terminus to the N-terminus onto a resin and cut to obtain a linear peptide. Then, the linear peptide is oxidized using natural oxidation to obtain a conotoxin anti wrinkle peptide cyclization solution containing 3 pairs of disulfide bonds. The crude peptide cyclization solution is purified to obtain high-purity peptide. Patent CN112279905A has been improved on this basis, which can effectively reduce the generation of missing impurities in linear peptides and improve yield. However, there are also problems such as high environmental pressure and increased costs.

4.The diverse applications of Mu conotoxin: from laboratories to dressing tables

4.1Anti wrinkle essence: directly hit dynamic wrinkles and pain points

Mu conotoxin can replace traditional medical beauty injections with a "topical application+transdermal absorption" mode for facial expressions such as forehead wrinkles and forehead wrinkles. For example, a brand of "Conotoxin Firming essence" is compounded with 0.015% Mu conotoxin and 5% acetylhexapeptide-8, and the user feedback is that "after 14 days of continuous use, the depth of smile lines will become lighter, and no powder will be stuck on the makeup".

4.2Sensitive Skin Exclusive: Gentle Repair Barrier

Research has shown that Mu conotoxin can enhance the antioxidant capacity of skin cells, reduce free radical damage, and promote the proliferation of keratinocytes. A certain soothing series added 0.01% Mu conotoxin and 2% centella asiatica glycoside, clinically validated to reduce the probability of sensitive muscle redness by 37%, with no reported irritation.

4.3Medical beauty assistance: prolonging the effect of botulinum toxin

Animal experiments have shown that Mu conotoxin can accelerate the onset time of botulinum toxin (from 48 hours to 2 hours) and prolong the duration of the effect by about 20%. Currently, medical beauty institutions have launched preoperative care packages using it as a "botulinum companion".

5. Market Prospects: The "Golden Player" of the Billion Dollar Anti Aging Race

According to Grand View Research, the global market for targeted peptide skincare products is expected to grow at a compound annual growth rate of 9.8% from 2023 to 2030. Mu conotoxin, with its "efficient, mild, and multifunctional" characteristics, is expected to seize the high-end anti-aging market share. Domestic chemical suppliers have achieved large-scale production, with raw material costs controlled at 1.5% -3% of the total formula cost, providing brands with cost-effective options.

6. Is it safe? Risk assessment from a scientific perspective

Existing research has not found any significant side effects of Mu conotoxin, but it is recommended to follow the principle of "low concentration, short-term use": safety assessment service risk assessment report
Sensitive muscles need to undergo patch testing before use;
Avoid mixing with acidic components (if acidic) to prevent damage to the disulfide bond structure;
Pregnant and lactating women should use caution (lack of relevant safety data).

7. Future outlook: More possibilities from the ocean to the skin

With the development of synthetic biotechnology, the production cost of Mu conotoxin is expected to be further reduced. In the future, efficient expression may be achieved through genetic engineering of yeast, and even customized peptide chains may be developed to meet the needs of different skin types. As stated by a cosmetics R&D director, "Mu conotoxin is not only an innovation in ingredients, but also a model for transforming marine biological resources into a beautiful economy. ”

Conclusion

Mu conotoxin is used as a core ingredient in anti wrinkle products, which can instantly fade crow's feet, forehead wrinkles, etc. The effect lasts for more than 8 hours and has no cytotoxicity or skin irritation. As a pharmacological probe, used for the study of ion channel subtypes; Potential treatments for neuropathic pain, epilepsy, and other diseases, such as achieving mass production through chemical synthesis (as an alternative to inefficient methods of extraction or gene recombination).
Asia has become the main production base, with Mu conotoxin with a purity of 95% -98% and packaging specifications ranging from 10mg to 1kg, meeting the needs of scientific research and industry.Xi'an Faithful BioTech provide you with the highest quality Mu conotoxin.Please contact me！E-mail ：sales10@faithfulbio.com .

Reference

1. mu-conotoxin | CAS#:936616-33-0[2025-08-25]
2. Mu Notaoxin Chemical Encyclopedia [2400-04-09]
3. u-Conotoxin CnIIIC, Mu conotoxin, 936616-33-0 [2022-04-25]
4. The price of mu conotoxin, an anti wrinkle agent for taro snails, is provided by Chengdu Yunxi Chemical Co., Ltd. in the book of public chemistry [January 14, 2025]
5. mu notoxin CAS #: 936616 Book of Chemistry [2022-07-04]
6. Mu cotoxin CnIIIC Chemistry Book
7. Decryption of Mu conotoxin CnIIIC: A technological breakthrough and formula for a new generation of anti-aging skin protectants ..[2025-07-24]
8. # Botulinum toxin # Botulinum toxin companion? Mu notoxin CnIII... from Doctor [23:03-10]
9. mu-conotaoxin 936616-33-0 peptide custom synthesis. Welcome to consult and order brands ..[2022-08-16]
10. Enhancing photon-axion conversion probability with squeezed coherent states[2025-06-17]
11. Mu cotoxin PIIIA Chemistry Book
12. Mu cotoxin CnIIIC Chemistry Book
13. Test of LGAD as Potential Next-Generation μSR Spectrometer Detectors[2025-05-15]
14. First Constraint on Axion-Photon Coupling $g_γ$ from Neutron Star Observations[2025-06-09]
16. Conotoxin mu conotoxin 936616 [2015-08-07]