What is SLU-PP-332 used for?

In summary, the ERR agonist SLU-PP-332 functions as an exercise mimetic inducing an acute aerobic exercise program that leads to myriad physiologic adaptations that are associated with exercise including increased skeletal muscle oxidative fibers, increased fatty acid oxidation, and enhanced exercise endurance.

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Brief Introduction

SLU-PP-332 is a synthetic small molecule, potent non-selective estrogen-associated receptor (ERR) agonist, which has the strongest effect on ERRα, with an EC50 of 98 nM. The SLU-PP-332 has aroused the interest of biomedical research due to its potential applications in metabolic health and exercise simulation.

MF: C18H14N2O2

MW: 290.32

CAS: 303760-60-3

Density: 1.20±0.1 g/cm ³ (Predicted)

Storage conditions: 2-8°C

Solubility of DMSO: 2mg/mL, clear (Warmed)

Acidity coefficient (pKa) : 8.44±0.15(Predicted)

Mechanism of Action

SLU-PP-332 functions as an ERRα agonist, enhancing mitochondrial activity and energy metabolism. It plays a key role in regulating fat oxidation, glucose metabolism, and thermogenesis, making it a potential candidate for treating metabolic disorders. The compound binds to the ligand-binding domain of ERRα, stabilizing its active conformation and enhancing its interaction with coactivator proteins, particularly PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha).

Research and Applications

SLU-PP-332 has been tested in several preclinical studies, including its ability to: Improve metabolic syndrome by enhancing mitochondrial efficiency. Induce exercise-mimetic effects in muscle tissue. Reverse age-related mitochondrial dysfunction. SLUPP-332 can enhance mitochondrial function and cellular respiration, increase type IIa oxidized skeletal muscle fibers, and enhance the exercise tolerance of skeletal muscle cell lines. SLU-PP-332 has the potential to be used in the research of metabolic diseases and the improvement of muscle function, and can also be used to improve metabolic disorders and aging.

Biological Effects

Metabolic Syndrome and Obesity

Studies in animal models have shown that SLU-PP-332 improves insulin sensitivity and reduces adiposity, suggesting its potential as an anti-obesity medication. SLU-PP-332 produced:

18-24% reduction in body weight.

30-35% decrease in white adipose tissue mass.

40% improvement in glucose tolerance.

25-30% decrease in fasting insulin levels.

Significant reduction in hepatic steatosis and inflammation.

What are the benefits of SLU PP?

SLU-PP-332 is a drug that mimics the effects of exercise, directing to augmented energy expenditure and closer body fat metabolism.   exercise initiation.   This agent improves a natural metabolic pathway that characteristically reacts to exercise, resulting in amplified energy expenditure, and extra body fat metabolism.

Does SLU-PP-332 work?

The initial research focused on normal-weight mice and revealed some pretty impressive results.  Mice treated with SLU-PP-332 were able to run for a whopping 70% longer and 45% further than their untreated counterparts.  That's like going from barely making it around the block to suddenly being ready for a half-marathon!

What are the side effects of SLU-PP-332?

Potential side effects: Observed effects include mild hyperthermia, increased heart rate, and transient changes in liver enzymes in animal studies.

How much is SLU-PP-332?

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Future Directions

Research on SLU-PP-332 and related ERR modulators continues to expand into new therapeutic areas:

Neurodegeneration: Preliminary studies suggest potential applications in Alzheimer's and Parkinson's diseases through improved mitochondrial function.

Cancer metabolism: Investigations into the role of ERR signaling in tumor energetics and potential therapeutic applications.

Longevity research: Exploration of ERR activation as a potential intervention to extend healthspan.

Personalized medicine approaches: Development of biomarkers to identify patients most likely to respond to ERR-targeted therapies.

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