How does Levetiracetam API powder restore order to millions of brains
What is Levetiracetam API powder ?
In the vast stars of the human brain, there will be an uncontrolled electrical storm-epilepsy. When millions of neurons suddenly and synchronously discharge abnormally, the body will be out of control, convulsed, confused and even collapsed instantly.
Modern medicine has never stopped looking for ways to treat epilepsy. Among many antiepileptic drugs, Levetiracetam API powder has gradually become a "stabilizer" against epilepsy because of its unique mechanism and good safety.Levetiracetam is a new type of antiepileptic product.
At present, it is believed that its antiepileptic effect is related to neurosynaptic vesicles protein. It is mainly used for partial seizures in children and adults over 4 years old.It takes effect quickly and has few side effects, so it is widely used in clinic. However, It can be secreted from milk, so it is not suitable for lactation. Teenagers should pay attention to the changes of mood and personality when using levetiracetam.
How does Levetiracetam API powder revive epileptic patients ?
Understanding epilepsy and treatment dilemma Epilepsy is one of the most common nervous system diseases, affecting more than 50 million people around the world. In China, there are about 10 million epileptic patients, many of whom are children and teenagers. Due to the randomness of disease onset, many patients are afraid to go out alone, unable to study and find jobs normally, and even live in fear and shame for a long time. Traditional antiepileptic drugs often have obvious defects: some will cause severe drowsiness and affect study and work; Some need to monitor the blood drug concentration frequently; Others will interact with other drugs. These limitations have prompted the medical community to constantly seek safer and more effective treatment programs. Its breakthrough characteristics: It is a new antiepileptic product, which has become one of the most widely used antiepileptic drugs in the world since it was approved in 1999. It is unique in that:
1. Innovative action mechanism; Different from traditional drugs, Levetiracetam API powder regulates the release of neurotransmitters by binding with SV2A protein in the brain, thus stabilizing neuronal activity. This mechanism is like "stepping on the brakes" for overexcited neurons, which can control abnormal discharge without affecting normal brain function.
2. Easy to use; It takes effect quickly, usually reaching the therapeutic concentration within a few days, and is not affected by eating.
3. Good safety; The side effects are relatively light, which does not affect cognitive function, and students and patients can use it with peace of mind, with little interaction with other drugs.
What is the mechanism of action of levetiracetam?
The mechanism of action of levetiracetam is very unique, and its core mechanism can be summarized as: binding with synaptic vesicles protein, regulating the release of neurotransmitters, thus stabilizing the excitability of neurons. Main target: Its main and only known direct molecular target is synaptic vesicles protein SV2A. When levetiracetam binds to SV2A protein, Levetiracetam API powder can regulate the exocytosis of synaptic vesicles. During the seizure, neurons will discharge excessively and synchronously, resulting in the release of a large number of neurotransmitters, thus exciting other neurons. Importantly, under normal physiological conditions, it hardly affects normal nerve transmission, which explains why it has fewer side effects and does not affect cognitive function. Inhibition of neuron supersynchronization: The essence of epileptic seizures is the abnormal synchronous discharge of a large number of neurons. Levetiracetam can effectively prevent this pathological synchronization without affecting normal neuronal activity. Under certain conditions, it can reverse the effects caused by some drugs that inhibit the function of GABA (a major inhibitory neurotransmitter), and indirectly enhance the inhibitory function of the brain. In a word, by combining with its unique target SV2A, it acts as a "regulator" to inhibit the abnormal over-discharge and synchronization of neurons in epileptic seizures, thus playing a broad-spectrum, safe and effective anti-epileptic role.
Why do doctors favor Levetiracetam API powder ?
Levetiracetam has obvious clinical advantages: broad-spectrum antiepileptic, effective for both partial and full-scale seizures. Good tolerance, dizziness, drowsiness and other side effects are lighter than traditional drugs. Rich dosage forms, suitable for patients of different ages and needs. It has become one of the most commonly used and favored drugs in pediatric epilepsy treatment, and many countries have approved it for epilepsy treatment in children over 4 years old. Old people often suffer from various diseases (such as hypertension and diabetes) and need to take a variety of drugs. The characteristics of levetiracetam make it the first choice for elderly patients. Of course, Levetiracetam API powder is not perfect. Some patients may have psychological and behavioral side effects such as mood swings, irritability and aggression, which are relatively common among children and adolescents and need close attention from doctors and their families. But overall, the benefits far outweigh the risks.
Identity change: from star products to commodities.
The market evolution of levetiracetam raw materials is a classic example. With the arrival of the patent cliff, this once innovative pharmaceutical raw material has been rapidly transformed into a bulk raw material product. According to market data, the global A scale remains above $3 billion per year, of which the market size in China is about RMB 4 billion. At present, the annual production capacity of levetiracetam in the world is estimated to exceed 5,000 tons, of which China and India contribute about 80% of the production. This pattern of production capacity distribution makes Asia a global supply center of raw materials for antiepileptic drugs.
Excellent quality: accurate control from molecular structure.
The molecular formula CHNO of levetiracetam seems simple, but it contains extraordinary therapeutic potential. As the core component of a new generation of antiepileptic drugs, its unique ring structure endows it with excellent blood-brain barrier penetration ability and can quickly reach the target. Modern API production has established a triple quality assurance system: 1) chemical purity. We ensure that the main component content is ≥99.5% through HPLC detection, and the known impurities are all below 0.1%. 2) Physical properties, particle size distribution is strictly controlled by laser particle size analyzer to ensure the uniformity of preparation production. 3) ensure the stability of crystal form. It is worth mentioning that the quality monitoring system we have established can monitor the production process in real time to ensure the quality consistency of each batch of products.
Conclusion:
As a professional biomedical enterprise, we know that every gram of Levetiracetam API powder is related to the health and hope of patients. We promise that we will continue to uphold the concept of "quality comes from design" and provide levetiracetam raw materials with safety, effectiveness and accessibility to patients all over the world through continuous technological innovation and quality improvement.
Xi'an Faithful BioTech Co., Ltd. combines cutting-edge production technology with comprehensive quality assurance to provide high-quality Levetiracetam raw powder that meets international pharmaceutical standards. Our commitment to excellent, competitive prices and technical support makes us the preferred partner of global healthcare providers and researchers. Let's go hand in hand, protect the health of the brain with the power of science and technology, and light the way for epilepsy patients to return to normal life. Because in our view, this is not only a white powder, but also a flower of hope bearing the trust of life. For detailed specifications and application guidelines of our Levetiracetam raw powder, please contact our technical team in sales11@faithfulbio.com to find out how our products can improve your formula.
References:
《Efficacy and tolerability of levetiracetam in adults with treatment-resistant partial-onset seizures》 Cereghino JJ, et al.Epilepsia. 2000.
《Levetiracetam for partial seizures: Results of a phase III multicenter double-blind placebo-controlled trial》Shorvon SD, et al.Epilepsia. 2000.
《ILAE official report: A practical clinical definition of epilepsy》Fisher RS, et al. Epilepsia. 2014
《Evidence-Based Guideline: Treatment of convulsive status epilepticus in children and adults: Report of the Guideline Committee of the American Epilepsy Society》 Glauser T, et al. Epilepsia. 2016.
《The story of levetiracetam: A reflection on the past and a vision for the future》Lyseng-Williamson KA. CNS Drugs. 2011.
《Levetiracetam: a comprehensive review》Abou-Khalil B.Expert Review of Neurotherapeutics. 2008.
《Levetiracetam for the treatment of neonatal seizures: A systematic review》Sharpe C, et al. Journal of Child Neurology. 2014.
《A systematic review of levetiracetam for the treatment of neuropathic pain》
