What is Somatostatin hormone powder?
What is Somatostatin hormone powder?
In the complex physiological regulatory network of human body, it is a kind of peptide hormone with extensive inhibitory effect, which is called "physiological braking system". It can not only precisely regulate the secretion of growth substances, insulin, glucagon and other key hormones, but also inhibit gastrointestinal peristalsis and digestive juice release, and play a central role in the treatment of neuroendocrine tumors, diabetes, pancreatitis and other diseases.
With the breakthrough of biopharmaceutical technology, Somatostatin hormone powder has moved from laboratory to industrialization, and has become the key starting material for the production of short-acting/long-acting preparations. Its purity, stability and innovative ability of dosage form directly affect the therapeutic effect and market competitiveness of downstream products.
Basic definition and chemical essence
It is a cyclic peptide hormone composed of 14 (SST-14) or 28 (SST-28) amino acids, which was first isolated from sheep hypothalamus in 1973. Its core function is to inhibit various physiological processes by binding to somatostatin receptor on target cell membrane.
It is the bulk drug form of this peptide hormone, usually white to off-white amorphous or crystalline powder.
Natural sources and industrial production;
Natural somatostatin is mainly secreted by hypothalamus, pancreatic δ cells and gastrointestinal D cells, but the content in vivo is extremely low, so it can not be directly extracted to meet clinical needs. Therefore, the industrial production of somatostatin powder is 100% dependent on chemical synthesis or gene recombination technology:
Chemical synthesis method: using solid-phase peptide synthesis technology, amino acids are connected one by one through protection strategy, and finally a cyclic structure is formed, and the purity can reach over 99%;
Gene recombination method: precursor protein is produced by Escherichia coli or yeast expression system, which is obtained by enzyme digestion and purification.
Core dosage forms and derivatives: Somatostatin hormone powder itself needs to be further processed into preparations.
Pharmacological mechanism of somatostatin: "master of physiological regulation" of multi-target inhibition
1. Receptor Target and Signal Pathway
It works by binding to five subtypes of receptors, and its functional specificity is determined by the difference in the distribution of different tissues:
Main targets: widely distributed in pituitary, pancreas, gastrointestinal tract and neuroendocrine tumors, mediating the core function of inhibiting insulin and glucagon secretion; Prioritize the regulation of insulin secretion; Participate in the regulation of apoptosis and proliferation;
2. Core physiological functions
(1) Endocrine regulation
Growth inhibitory substances: act on the anterior pituitary gland to reduce the secretion of growth substances;
Inhibition of insulin and glucagon: regulating blood sugar balance;
(2) Exocrine and gastrointestinal function regulation
Inhibition of gastric acid, pepsin, pancreatin and bile secretion (to protect the pancreas from excessive stimulation, for acute pancreatitis); Slow gastrointestinal peristalsis and absorption (reduce diarrhea, used for intestinal fistula or chemotherapy-related diarrhea).
(3) tumor treatment potential
Directly inhibit the proliferation of tumor cells (block the growth factor signal); Blocking angiogenesis (indirectly inhibiting tumor nutrition supply); Combined with radionuclides to achieve targeted therapy.
Production technology of Somatostatin hormone powder: from peptide chain synthesis to high purity raw materials
1. Receptor Target and Signal Pathway
It works by binding to five subtypes of receptors, and its functional specificity is determined by the difference in the distribution of different tissues:
Main targets: widely distributed in pituitary, pancreas, gastrointestinal tract and neuroendocrine tumors, mediating the core function of inhibiting insulin and glucagon secretion; Prioritize the regulation of insulin secretion; Participate in the regulation of apoptosis and proliferation;
2. Core physiological functions
(1) Endocrine regulation
Growth inhibitory substances: act on the anterior pituitary gland to reduce the secretion of growth substances;
Inhibition of insulin and glucagon: regulating blood sugar balance;
(2) Exocrine and gastrointestinal function regulation
Inhibition of gastric acid, pepsin, pancreatin and bile secretion (to protect the pancreas from excessive stimulation, for acute pancreatitis); Slow gastrointestinal peristalsis and absorption (reduce diarrhea, used for intestinal fistula or chemotherapy-related diarrhea).
(3) tumor treatment potential
Directly inhibit the proliferation of tumor cells (block the growth factor signal); Blocking angiogenesis (indirectly inhibiting tumor nutrition supply); Combined with radionuclides to achieve targeted therapy.
Challenges and opportunities coexist: the key proposition of industry development
1. Main challenges
The complexity of the production process is high: the yield of polypeptide synthesis is low and the purification cost is high, which limits the large-scale supply;
High cost and accessibility: the average annual treatment cost of long-acting analogues exceeds 100,000 yuan (China), which is difficult for some patients to afford;
Quality difference: There may be subtle differences in the original drug, and we are making great efforts to control the quality consistency of each batch of products, which has been well evaluated.
2. Core opportunities
Rigid growth of demand: the global demand is increasing year by year, and somatostatin analogues are the standard treatment scheme;
Technological innovation: we are continuously increasing technical input, and technologies such as continuous flow synthesis and AI-assisted peptide sequence design can reduce production costs; Somatostatin hormone powder's technological innovation, reducing costs and increasing efficiency.
Potential of emerging markets: The number of countries with aging population in the world is increasing, and the demand for neuroendocrine diseases and diabetes-related indications is rising rapidly.
Conclusion:
From the "physiological brake" of regulating hormone secretion to the "targeted weapon" of neuroendocrine tumor treatment, it has become an irreplaceable key raw material in modern pharmaceutical industry because of its multi-target inhibition characteristics and wide clinical value. With the innovation of dosage forms, the rise of bio-similar products and the development of precision medicine, its industrial chain (from raw material drug synthesis to terminal preparations) will continue to evolve in the direction of high efficiency, low cost and personalization.
For us, mastering the production technology of high-purity somatostatin powder (especially the cyclization and purification process) is not only a strategic fulcrum in the field of endocrinology and tumor, but also a core competitiveness to cope with the upgrading of medical needs in the future.
Xi'an Faithful BioTech Co., Ltd. combines cutting-edge production technology with comprehensive quality assurance to provide high-quality Somatostatin hormone powder that meets international pharmaceutical standards. Our commitment to excellent, competitive prices and technical support makes us the preferred partner of global healthcare providers and researchers. Please contact our technical team in sales11@faithfulbio.com to find out how our products can improve your formula.
This is a list of the names of the core scientific research documents that I referred to and relied on in the process of writing a soft article. These documents provide solid scientific evidence for the efficacy and mechanism mentioned in this paper.
- Therapeutic uses of somatostatin and its analogues: Current view and potential applications
- Somatostatin and somatostatin receptors: implications for neoplastic growth and cancer biology
- Role of somatostatin and its analogues in the treatment of acute and chronic pancreatitis
- Somatostatin infusion or emergency sclerotherapy for variceal haemorrhage
- Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a Meta-analysis
- A prospective randomized trial comparing somatostatin, balloon tamponade and the combination of both methods in the management of acute variceal haemorrhage
- Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: a controlled study
- Severe acute bleeding from portal colopathy controlled by somatostatin: a case report
- The management of gastrointestinal haemorrhage by somatostatin after apparently successful endoscopic injection sclerotherapy for bleeding oesophageal varices
- Somatostatin and its analogues in peptic ulcer bleeding: facts and pathophysiological aspects
- Management of massive upper gastrointestinal haemorrhage from multiple sites of peptic ulceration with somatostatin and octreotide: a report of five Cases
- High-dose pantoprazole continuous infusion is superior to somatostatin after endoscopic hemostasis in patients with peptic ulcer bleeding
- Effectiveness of somatostatin on malignant bowel obstruction in patients with inoperable carcinoma
